Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tsuhako A"'
Autor:
Akihiro Tokushige, Yumi Ikehara, Takahiro Tadokoro, Takehiro Kinjo, Taketo Zamami, Manabu Kakinohana, Sumire Taira, Shinichiro Ueda, Hiroshi Ohtsu, Chiemi Tsuhako
Publikováno v:
Anesthesia and analgesia. 130(4)
BACKGROUND In this randomized, triple-blind, placebo-controlled trial, we tested the hypothesis that perioperative acetaminophen administration has a prophylactic effect on postoperative shivering. METHODS Forty-five women scheduled for gynecological
Autor:
Jung, Kyung Hae, LoRusso, Patricia, Burris, Howard, Gordon, Michael, Bang, Yung-Jue, Hellmann, Matthew, Cervantes, Andres, de Olza, Maria Ochoa, Marabelle, Aurélien, Hodi, F Stephen, Ahn, Myung-Ju, Emens, Leisha, Barlesi, Fabrice, Hamid, Omid, Calvo, Emiliano, McDermott, David, Soliman, Hatem, Rhee, Ina, Lin, Ray, Pourmohamad, Tony, Suchomel, Julia, Tsuhako, Amy, Morrissey, Kari, Mahrus, Sami, Morley, Roland, Pirzkall, Andrea, Davis, S Lindsey, Hodi, F. Stephen, Davis, S. Lindsey
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Clinical Cancer Research
Clinical Cancer Research, American Association for Cancer Research, 2019, 25 (11), pp.3220-3228. ⟨10.1158/1078-0432.CCR-18-2740⟩
Clinical Cancer Research, 2019, 25 (11), pp.3220-3228. ⟨10.1158/1078-0432.CCR-18-2740⟩
Clin Cancer Res
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Clinical Cancer Research
Clinical Cancer Research, American Association for Cancer Research, 2019, 25 (11), pp.3220-3228. ⟨10.1158/1078-0432.CCR-18-2740⟩
Clinical Cancer Research, 2019, 25 (11), pp.3220-3228. ⟨10.1158/1078-0432.CCR-18-2740⟩
Clin Cancer Res
Purpose: IDO1 induces immune suppression in T cells through l-tryptophan (Trp) depletion and kynurenine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T cells and hyperactivating regulatory T cells (Treg). Navoximod is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97784b8a4ed5b767c2db064581ed9c52
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2838
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2838
Autor:
Rika Tsuhako, Chihiro Sugita, Wataru Watanabe, Hiroyuki Wakabayashi, Hiroki Yoshida, Masahiko Kurokawa, K Shin
Publikováno v:
Acta virologica. 62(4)
Hypothiocyanite (OSCN-) is a natural component of human saliva and is produced by the lactoperoxidase (LPO)/thiocyanate/hydrogen peroxide (H2O2) system. OSCN- has been previously shown to exhibit antiviral activity against influenza viruses (IFV) A/H
Autor:
Neal G. Copeland, Asano Tsuhako, Nancy A. Jenkins, Hideto Koso, Alistair G. Rust, Eli Lyons, Jerrold M. Ward, Sumiko Watanabe, David J. Adams
Publikováno v:
Cancer Research. 74:2351-2361
Medulloblastoma is the most common pediatric brain tumor, and in ∼25% of cases, it is driven by aberrant activation of the Sonic Hedgehog (SHH) pathway in granule neuron precursor (GNP) cells. In this study, we identified novel medulloblastoma driv
Autor:
Erick Wang Co, John M. Nuss, Stefan Engst, Monica Rodriquez, Jason Chen, Xiang Wu, Moon Hwan Kim, Peiwen Yu, Fawn Qian, Yeping Zhao, Morrison B. Mac, Peter Lamb, Wei Cheng, Wei Xu, Kwang-Ai Won, Frauke Bentzien, Wentao Zhang, Thomas J. Stout, Dana T. Aftab, Jason Jevious Parks, Jeffrey H. Till, Amy Lew Tsuhako, Rhett Ronald Klein, Levina Goon, Donna T. Le, F. Michael Yakes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4979-4985
Variously substituted indolin-2-ones were synthesized and evaluated for activity against KDR, Flt-1, FGFR-1 and PDGFR. Extension at the 5-position of the oxindole ring with ethyl piperidine (compound 7i) proved to be the most beneficial for attaining
Autor:
Arlyn Arcalas, Richards Steven J, Amy Lew Tsuhako, Naing Aay, Kim Ferguson, Arthur Plonowski, Gordon Mark Stott, Wei Xu, Jenny Young, Peiwen Yu, Wentao Zhang, Charles R. Holst, Kevin Noson, Cristiana A. Zaharia, Brown S David, Hongwang Du, Manisha Mohan, Ping Huang, Thomas J. Stout, Adam A. Galan, Patrick Kearney, David W. Markby, Stefan Engst, Maurizio Franzini, Peiwen Zhou, John M. Nuss, Brian Kane, Kenneth J. Shaw, Elena S. Koltun, Scott Robertson, Moon Hwan Kim, Vicky Chan, Jia Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3727-3731
CDC7 is a serine/threonine kinase that has been shown to be required for the initiation and maintenance of DNA replication. Up-regulation of CDC7 is detected in multiple tumor cell lines, with inhibition of CDC7 resulting in cell cycle arrest. In thi
Autor:
Kenneth D. Rice, Neel Kumar Anand, Moon Hwan Kim, Jason Jevious Parks, Tsze H. Tsang, Donna T. Le, Larisa Dubenko, Erick Wang Co, Steven Charles Defina, Joerg Bussenius, Lynne Canne-Bannen, David J. Matthews, John M. Nuss, Stefan Engst, Simona Costanzo, Richard George Khoury, A. Douglas Laird, Diva Sze-Ming Chan, Wei Xu, Owen Joseph Bowles, Maurizio Franzini, Vasu Jammalamadaka, Ping Huang, Amy Lew Tsuhako, Yong Wang, David W. Markby, Baili Chen, Morrison B. Mac, Rhett Ronald Klein, Nicole Miller, Charles M. Blazey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2693-2697
Activation of the PI3K/Akt/mTOR kinase pathway is frequently associated with human cancer. Selective inhibition of p70S6Kinase, which is the last kinase in the PI3K pathway, is not sufficient for strong tumor growth inhibition and can lead to activat
Autor:
Carlos Eduardo Pereira, Gerson Chadi, Maria Heloisa Tsuhako, Edlaine Linares, Ohara Augusto, Selma Giorgio
Publikováno v:
Free Radical Biology & Medicine
Multiple sclerosis (MS) is a progressive inflammatory and/or demyelinating disease of the human central nervous system (CNS). Most of the knowledge about the pathogenesis of MS has been derived from murine models, such as experimental autoimmune ence
Autor:
Kenji Nakamori, T. Kosugi, Yasuaki Tamura, Kazuhiro Ogi, Wakatsu Tsuhako, Noriyuki Sato, T. Shinya, Hiroyoshi Hiratsuka, Gosei Ueda, Hajime Sunakawa
Publikováno v:
International Journal of Oral and Maxillofacial Surgery. 35:356-361
Alteration in expression of E-cadherin and catenins is associated with loss of differentiation, acquisition of an invasive phenotype and poor clinical outcome in many types of cancer. To identify molecular prognostic markers, membrane expression leve
Autor:
Manuel Hidalgo, Anne Uyei, J. Paul Eder, Jordan Berlin, Andrea Pirzkall, S. Gail Eckhardt, Bruce McCall, Patricia LoRusso, Amy Lew Tsuhako, Christopher H. Lieu, Amy V. Kapp, Josep Tabernero, Andrew H. Ko, David E. Gerber, Andrés Cervantes
Publikováno v:
The Oncologist
Lessons Learned Cobimetinib and duligotuzumab were well tolerated as single agents and in combination with other agents. The cobimetinib and duligotuzumab combination was associated with increased toxicity, most notably gastrointestinal, and limited