Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Steven A. Carr"'
Autor:
Meenakshi Anurag, Eric J. Jaehnig, Karsten Krug, Jonathan T. Lei, Erik J. Bergstrom, Beom-Jun Kim, Tanmayi D. Vashist, Anh Minh Tran Huynh, Yongchao Dou, Xuxu Gou, Chen Huang, Zhiao Shi, Bo Wen, Viktoriya Korchina, Richard A. Gibbs, Donna M. Muzny, Harshavardhan Doddapaneni, Lacey E. Dobrolecki, Henry Rodriguez, Ana I. Robles, Tara Hiltke, Michael T. Lewis, Julie R. Nangia, Maryam Nemati Shafaee, Shunqiang Li, Ian S. Hagemann, Jeremy Hoog, Bora Lim, C. Kent Osborne, D.R. Mani, Michael A. Gillette, Bing Zhang, Gloria V. Echeverria, George Miles, Mothaffar F. Rimawi, Steven A. Carr, Foluso O. Ademuyiwa, Shankha Satpathy, Matthew J. Ellis
Publikováno v:
Cancer Discovery. 12:2586-2605
Microscaled proteogenomics was deployed to probe the molecular basis for differential response to neoadjuvant carboplatin and docetaxel combination chemotherapy for triple-negative breast cancer (TNBC). Proteomic analyses of pretreatment patient biop
Autor:
Thomas R. Austin, Caitlin P. McHugh, Jennifer A. Brody, Joshua C. Bis, Colleen M. Sitlani, Traci M. Bartz, Mary L. Biggs, Nisha Bansal, Petra Buzkova, Steven A. Carr, Christopher R. deFilippi, Mitchell S. V. Elkind, Howard A. Fink, James S. Floyd, Alison E. Fohner, Robert E. Gerszten, Susan R. Heckbert, Daniel H. Katz, Jorge R. Kizer, Rozenn N. Lemaitre, W. T. Longstreth, Barbara McKnight, Hao Mei, Kenneth J. Mukamal, Anne B. Newman, Debby Ngo, Michelle C. Odden, Ramachandran S. Vasan, Ali Shojaie, Noah Simon, George Davey Smith, Neil M. Davies, David S. Siscovick, Nona Sotoodehnia, Russell P. Tracy, Kerri L. Wiggins, Jie Zheng, Bruce M. Psaty
Publikováno v:
Austin, T R, McHugh, C P, Brody, J A, Bis, J C, Sitlani, C M, Bartz, T M, Biggs, M L, Bansal, N, Buzkova, P, Carr, S A, deFilippi, C R, Elkind, M SV, Fink, H A, Floyd, J S, Fohner, A E, Gerszten, R E, Heckbert, S R, Katz, D H, Kizer, J R, Lemaitre, R N, Longstreth, W T, McKnight, B, Mei, H, Mukamal, K J, Newman, A B, Ngo, D, Odden, M C, Vasan, R S, Shojaie, A, Etkind, S N, Davey Smith, G, Davies, N M, Siscovick, D S, Sotoodehnia, N, Tracy, R P, Wiggins, K L, Zheng, J & Psaty, B M 2022, ' Proteomics and Population Biology in the Cardiovascular Health Study (CHS) : design of a study with mentored access and active data sharing ', European Journal of Epidemiology, vol. 37, pp. 755–765 . https://doi.org/10.1007/s10654-022-00888-z
BackgroundIn the last decade, genomic studies have identified and replicated thousands of genetic associations with measures of health and disease and contributed to the understanding of the etiology of a variety of health conditions. Proteins are ke
Autor:
Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Nan Liu, Taiju Utsugisawa, Alex M. Tseng, Samuel A. Myers, Jeffrey M. Verboon, Jacob C. Ulirsch, Wendy Luo, Christoph Muus, Claudia Fiorini, Meagan E. Olive, Christopher M. Vockley, Mathias Munschauer, Abigail Hunter, Hiromi Ogura, Toshiyuki Yamamoto, Hiroko Inada, Shinichiro Nakagawa, Shuichi Ohzono, Vidya Subramanian, Roberto Chiarle, Bertil Glader, Steven A. Carr, Martin J. Aryee, Anshul Kundaje, Stuart H. Orkin, Aviv Regev, Timothy L. McCavit, Hitoshi Kanno, Vijay G. Sankaran
Publikováno v:
Blood
Master regulators, such as the hematopoietic transcription factor (TF) GATA1, play an essential role in orchestrating lineage commitment and differentiation. However, the precise mechanisms by which such TFs regulate transcription through interaction
Autor:
Eva J. Schaefer, Helen C. Wang, Hannah Q. Karp, Clifford A. Meyer, Paloma Cejas, Micah D. Gearhart, Emmalee R. Adelman, Iman Fares, Annie Apffel, Klothilda Lim, Yingtian Xie, Christopher J. Gibson, Monica Schenone, H. Moses Murdock, Eunice S. Wang, Lukasz P. Gondek, Martin P. Carroll, Rahul S. Vedula, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Marlise R. Luskin, Steven A. Carr, Henry W. Long, Vivian J. Bardwell, Maria E. Figueroa, R. Coleman Lindsley
Publikováno v:
Blood Cancer Discov
Polycomb repressive epigenetic complexes are recurrently dysregulated in cancer. Unlike polycomb repressive complex 2 (PRC2), the role of PRC1 in oncogenesis and therapy resistance is not well-defined. Here, we demonstrate that highly recurrent mutat
Autor:
Shankha Satpathy, Fernanda Martins Rodrigues, Li Ding, Humam Kadara, Chandra Goparaju, Steven A. Carr, Irena Lanc, Jeffrey P. Ward, Ignacio I. Wistuba, Siddhartha Devarakonda, Ashiq Masood, Robert S. Fulton, Harvey I. Pass, Richard K. Wilson, Lucinda Fulton, Ramaswamy Govindan, Kymberlie H. Pepin, Daniel Morgensztern, Yize Li, Michael A. Gillette, Saiama N. Waqar, Sumithra Sankararaman
Publikováno v:
J Clin Oncol
PURPOSE Approximately 10%-40% of patients with lung cancer report no history of tobacco smoking (never-smokers). We analyzed whole-exome and RNA-sequencing data of 160 tumor and normal lung adenocarcinoma (LUAD) samples from never-smokers to identify
Autor:
Patrick C. Lee, Susan Klaeger, Phuong M. Le, Keegan Korthauer, Jingwei Cheng, Varsha Ananthapadmanabhan, Thomas C. Frost, Jonathan D. Stevens, Alan Y.L. Wong, J. Bryan Iorgulescu, Anna Y. Tarren, Vipheaviny A. Chea, Isabel P. Carulli, Camilla K. Lemvigh, Christina B. Pedersen, Ashley K. Gartin, Siranush Sarkizova, Kyle T. Wright, Letitia W. Li, Jason Nomburg, Shuqiang Li, Teddy Huang, Xiaoxi Liu, Lucas Pomerance, Laura M. Doherty, Annie M. Apffel, Luke J. Wallace, Suzanna Rachimi, Kristen D. Felt, Jacquelyn O. Wolff, Elizabeth Witten, Wandi Zhang, Donna Neuberg, William J. Lane, Guanglan Zhang, Lars R. Olsen, Manisha Thakuria, Scott J. Rodig, Karl R. Clauser, Gabriel J. Starrett, John G. Doench, Sara J. Buhrlage, Steven A. Carr, James A. DeCaprio, Catherine J. Wu, Derin B. Keskin
Publikováno v:
Lee, P C, Klaeger, S, Le, P M, Korthauer, K, Cheng, J, Ananthapadmanabhan, V, Frost, T C, Stevens, J D, Wong, A Y L, Iorgulescu, J B, Tarren, A Y, Chea, V A, Carulli, I P, Lemvigh, C K, Pedersen, C B, Gartin, A K, Sarkizova, S, Wright, K T, Li, L W, Nomburg, J, Li, S, Huang, T, Liu, X, Pomerance, L, Doherty, L M, Apffel, A M, Wallace, L J, Rachimi, S, Felt, K D, Wolff, J O, Witten, E, Zhang, W, Neuberg, D, Lane, W J, Zhang, G, Olsen, L R, Thakuria, M, Rodig, S J, Clauser, K R, Starrett, G J, Doench, J G, Buhrlage, S J, Carr, S A, DeCaprio, J A, Wu, C J & Keskin, D B 2022, ' Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma ', Journal of Clinical Investigation, vol. 132, no. 13, e151666 . https://doi.org/10.1172/JCI151666
Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I–low, neuroendocrine carcinoma of the skin often caused by the Merkel c
Autor:
Daniel H. Katz, Robert E. Gerszten, Lori L. Jennings, Changyu Shen, Theresa Margarethe Rienmüller, Christian Baumgartner, Claude Bouchard, Mark A. Sarzynski, Jacob L. Barber, Pierre M. Jean Beltran, Michelle J. Keyes, Daniela Schranner, Sujoy Ghosh, Robert Ross, Bennet Peterson, Usman A. Tahir, Jeremy M. Robbins, Shuliang Deng, Steven A. Carr
Publikováno v:
Nat Metab
Maximal oxygen uptake (VO2max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO2max, and of increases of VO2max in resp
Autor:
Christina R. Hartigan, Benjamin L. Ebert, Caroline Stanclift, Namrata D. Udeshi, Monica Schenone, Amanuel Bizuayehu, Veronica Kovalcik, Tanya Svinkina, Alexis Vedder, Marie McConkey, Eric Padron, Sebastian Koochaki, Roger Belizaire, Steven A. Carr, Lei Sun
Publikováno v:
Blood
Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in myeloid neoplasms, including 10% to 20% of chronic myelomonocytic leukemi
Autor:
Jinjin Guo, Tanya Svinkina, Alice Y. Ting, Namrata D. Udeshi, Luye Mu, Dan Wang, John M. Asara, David Rocco, Steven A. Carr, Dominique K. Carey, Amanda S. Meyer, Yanhui Hu, Rui Yang, Jill A. McMahon, Tess C. Branon, Andrew P. McMahon, Ilia A. Droujinine, Norbert Perrimon, Areya Tabatabai, Rebecca Zeng, Justin A. Bosch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Conventional approaches to identify secreted factors that regulate homeostasis are limited in their abilities to identify the tissues/cells of origin and destination. We established a platform to identify secreted protein trafficking between organs u
Autor:
Giacomo Oliveira, Kari Stromhaug, Nicoletta Cieri, J. Bryan Iorgulescu, Susan Klaeger, Jacquelyn O. Wolff, Suzanna Rachimi, Vipheaviny Chea, Kate Krause, Samuel S. Freeman, Wandi Zhang, Shuqiang Li, David A. Braun, Donna Neuberg, Steven A. Carr, Kenneth J. Livak, Dennie T. Frederick, Edward F. Fritsch, Megan Wind-Rotolo, Nir Hacohen, Moshe Sade-Feldman, Charles H. Yoon, Derin B. Keskin, Patrick A. Ott, Scott J. Rodig, Genevieve M. Boland, Catherine J. Wu
Publikováno v:
Nature
Within the tumour microenvironment, CD4(+) T cells can promote or suppress antitumour responses through the recognition of antigens presented by human leukocyte antigen (HLA) class II molecules(1,2), but how cancers co-opt these physiologic processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419989af99753a8028e9ec14688c4cce
https://europepmc.org/articles/PMC9815755/
https://europepmc.org/articles/PMC9815755/