Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Stephen H. Bryant"'
Publikováno v:
Bioinformatics. 33:1621-1629
Motivation Genetic variants in drug targets and metabolizing enzymes often have important functional implications, including altering the efficacy and toxicity of drugs. Identifying single nucleotide variants (SNVs) that contribute to differences in
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1825
PubChem ( https://pubchem.ncbi.nlm.nih.gov ) is a key chemical information resource, developed and maintained by the US National Institutes of Health. The present chapter describes how to find potential multitarget ligands from PubChem that would be
While novel technologies such as high-throughput screening have advanced together with significant investment by pharmaceutical companies during the past decades, the success rate for drug development has not yet been improved prompting researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b20b2a7041a66c8e42633897084b981
https://europepmc.org/articles/PMC6781586/
https://europepmc.org/articles/PMC6781586/
Publikováno v:
The AAPS journal. 19(5)
The prediction of drug-target interactions (DTIs) is of extraordinary significance to modern drug discovery in terms of suggesting new drug candidates and repositioning old drugs. Despite technological advances, large-scale experimental determination
Autor:
Siqian He, Jian Zhang, Jiyao Wang, Tiejun Cheng, Benjamin A. Shoemaker, Asta Gindulyte, Yanli Wang, Tugba O. Suzek, Stephen H. Bryant
Publikováno v:
Nucleic Acids Research
PubChem's BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for archiving biological tests of small molecules generated through high-throughput screening experiments, medicinal chemistry studies, chemical biology research and
Publikováno v:
Journal of Chemical Information and Modeling
Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) are protein kinases that are promising targets for treatment of diseases caused by abnormal gene splicing. 6-Arylquinazolin-4-amines have been recent
Publikováno v:
The AAPS Journal
Structure-based virtual screening (SBVS) has been widely applied in early-stage drug discovery. From a problem-centric perspective, we reviewed the recent advances and applications in SBVS with a special focus on docking-based virtual screening. We e
Autor:
William C. Eckelman, Arvind Chopra, Anne E. Menkens, Liang Shan, Stephen H. Bryant, Martin Latterner, Kam Leung
Publikováno v:
Molecular Imaging and Biology. 14:4-13
The purpose of writing this review is to showcase the Molecular Imaging and Contrast Agent Database (MICAD; www.micad.nlm.nih.gov ) to students, researchers, and clinical investigators interested in the different aspects of molecular imaging. This da
Publikováno v:
Journal of Chemical Information and Modeling
Molecular target identification is of central importance to drug discovery. Here, we developed a computational approach, named bioactivity profile similarity search (BASS), for associating targets to small molecules by using the known target annotati
Autor:
Evan E Bolton, Stephen H. Bryant, Karen Karapetyan, Jian Zhang, Yanli Wang, Tugba O. Suzek, Svetlana Dracheva, Benjamin A. Shoemaker, Jiyao Wang, Jewen Xiao
Publikováno v:
Nucleic Acids Research
The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental des