Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Richard Appleton"'
Autor:
Anthony G Marson, Girvan Burnside, Richard Appleton, Dave Smith, John Paul Leach, Graeme Sills, Catrin Tudur-Smith, Catrin O Plumpton, Dyfrig A Hughes, Paula R Williamson, Gus Baker, Silviya Balabanova, Claire Taylor, Richard Brown, Dan Hindley, Stephen Howell, Melissa Maguire, Rajiv Mohanraj, Philip EM Smith
Publikováno v:
Health Technology Assessment, Vol 25, Iss 75 (2021)
Background: Levetiracetam (Keppra®, UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran®, Eisai Co. Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for generalised
Externí odkaz:
https://doaj.org/article/a6bb255ed29d423996d9ff3ae50435f9
Autor:
Elizabeth Lee, Anand Iyer, Amy Humphreys, Carrol Gamble, Richard Appleton, Helen Hickey, Joanne Noblet, Mark D Lyttle, Shrouk Messahel, Louise Roper, Naomi Rainford, Kerry Woolfall
Publikováno v:
EMERGENCY MEDICINE JOURNAL
Emergency Medicine Journal : EMJ
Emergency Medicine Journal : EMJ
BackgroundAlternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior consent (RWPC) involves practitioners approaching parents after an intervention has been given and seek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a727f999e78c76003e129ffed6ea530
Autor:
Paul Tate, Anand Iyer, Sarah Potter, Nadia Al Najjar, Vicki Evans, Richard Appleton, Amy Humphreys, Mark D Lyttle, Naomi Rainford, Elizabeth Lee, Kerry Woolfall, Helen Hickey, Shrouk Messahel, Carrol Gamble, Louise Roper, Joanne Noblet
Publikováno v:
Health Technology Assessment
Health technology assessment (Winchester, England)
Health Technology Assessment, Vol 24, Iss 58 (2020)
Health Technol Assess
Health technology assessment (Winchester, England)
Health Technology Assessment, Vol 24, Iss 58 (2020)
Health Technol Assess
Background Convulsive status epilepticus is the most common neurological emergency in children. Its management is important to avoid or minimise neurological morbidity and death. The current first-choice second-line drug is phenytoin (Epanutin, Pfize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5503576625a8d81ca9b42044ca91409
Autor:
Marvin Johnson, Phil Smith, Dyfrig A. Hughes, Catrin Plumpton, John Paul Leach, Girvan Burnside, Silviya Balabanova, Paula R Williamson, Gus A. Baker, Richard Appleton, Graeme J. Sills, Catrin Tudur-Smith, Claire Taylor, Munir Pirmohamed, Anthony G Marson
Publikováno v:
BMJ Open
BMJ open
BMJ Open, Vol 10, Iss 8 (2020)
BMJ open
BMJ Open, Vol 10, Iss 8 (2020)
IntroductionAntiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Over the past 20 years, a number of new drugs have been approved for National Health Service (NHS) use on the basis of information from short-term trials that demonstrate
Autor:
Mark D Lyttle, Amy Humphreys, Shrouk Messahel, Joanne Noblet, Helen Hickey, Anand Iyer, Richard Appleton, Elizabeth Lee, Naomi Rainford, Kerry Woolfall, Carrol Gamble, Louise Roper
Publikováno v:
Emergency Medicine Journal : EMJ
Emergency Medicine Journal
Emergency Medicine Journal
BackgroundKey challenges to the successful conduct of The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children (EcLiPSE) trial were identified at the pre-trial stage. These included practitioner anxieties about conduc
Publikováno v:
Seizure. 57:66-69
To compare the de novo incidence of Panayiotopoulos syndrome (PS, early-onset childhood occipital epilepsy) and a common epilepsy syndrome, benign epilepsy with centro-temporal spikes (BECTS), in children and young people.The incidence of PS and BECT
Autor:
Matthew Wong, Sam M. Greenwood, Orrin Devinsky, Anup D. Patel, Kenneth Sommerville, Richard Appleton, Gilmour Morrison, Cynthia L. Harden, Elizabeth A. Thiele
Publikováno v:
Neurology
Wong, M H 2018, ' Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome ', Neurology, vol. 90, no. 14, pp. e1204-e1211 . https://doi.org/10.1212/WNL.0000000000005254
Wong, M H 2018, ' Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome ', Neurology, vol. 90, no. 14, pp. e1204-e1211 . https://doi.org/10.1212/WNL.0000000000005254
ObjectiveTo evaluate the safety and preliminary pharmacokinetics of a pharmaceutical formulation of purified cannabidiol (CBD) in children with Dravet syndrome.MethodsPatients aged 4–10 years were randomized 4:1 to CBD (5, 10, or 20 mg/kg/d) or pla
Autor:
Sarah Doyle, Anand Iyer, Stefano Seri, Lesley Notghi, Rachel Thornton, Sushma Goyal, Tim Martland, Peter Bill, Ronit M. Pressler, Elliott Warren, Sarah Rushton, Nick Kane, Richard Appleton, Stewart Boyd, Alan Worley
Publikováno v:
Seizure. 50:6-11
Purpose Paediatric Epilepsy surgery in the UK has recently been centralised in order to improve expertise and quality of service available to children. Video EEG monitoring or telemetry is a highly specialised and a crucial component of the pre-surgi
Autor:
Helen Hickey, Amy Humphreys, Elizabeth Lee, Anand Iyer, Joanne Noblet, Shrouk Messahel, Mark D Lyttle, Carrol Gamble, Richard Appleton, Louise Roper, Naomi Rainford, Kerry Woolfall
Publikováno v:
TRIALS
Trials, Vol 20, Iss 1, Pp 1-14 (2019)
Trials
Trials, Vol 20, Iss 1, Pp 1-14 (2019)
Trials
Background EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c55a6f7e1fa04acad553ac77f796ad7
Autor:
Kollencheri Puthenveettil Vinayan, Richard Appleton, Jaime Carrizosa-Moog, Margarete Pfäfflin, Hassan Hosny, Marco Mula, Howard Ring, Isabelle Desguerre, Michel Baulac, Christina Grant, Helen Cross, Sylvain Rheims, Laura Jurasek, Lawrence W. Brown, Rima Nabbout, Renée A. Shellhaas, Carole S Camfield, Peter Camfield, Danielle M. Andrade, Eleonor Ben Menachem, Elaine C. Wirrell
Publikováno v:
Epilepsybehavior : EB. 93
Objective evidence is limited for the value of transition programs for youth with chronic illness moving from pediatric to adult care; however, such programs intuitively "make sense". We describe the strengths and weaknesses of a variety of transitio