Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Quansheng Zhou"'
Autor:
Zhe Zhao, Shufen Xiang, Bin Zhang, Chunping Lv, Zihe Huo, Zhifei Cao, Mei Meng, Gaochuan Zhang, Quansheng Zhou, Liang Dong, Lan Yang, Bo Yang, Pan Zhang, Shucheng Shi, Xingdong Xu
Publikováno v:
Cell Death Differ
Cancer cells are defective in DNA repair, so they experience increased DNA strand breaks, genome instability, gene mutagenesis, and tumorigenicity; however, multiple classic DNA repair genes and pathways are strongly activated in malignant tumor cell
Autor:
Jindan Qi, Mengli Zhang, Yuxi Liu, Wei Lu, Quansheng Zhou, Yingnan Qiao, Mei Meng, Zhou Zhou, Peng Xu, Yanxing Hu, Zhe Zhao
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Background Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic. Methods We used TNBC cells and xenografted mice as models to explore
Autor:
Lina Wang, Ningzheng Dong, Yizhi Jiang, Xiaofei Qi, Yae Hu, Ruhong Yan, Can Wang, Quansheng Zhou, Qingyu Wu, Meng Liu
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 8, Iss 5, Pp 2348-2359 (2019)
Cancer Medicine, Vol 8, Iss 5, Pp 2348-2359 (2019)
Transmembrane serine proteases have been implicated in the development and progression of solid and hematological cancers. Human airway trypsin‐like protease 4 (HAT‐L4) is a transmembrane serine protease expressed in epithelial cells and exocrine
Autor:
Mengli Zhang, Di Yu, Bin Zhang, Zhifei Cao, Pan Zhang, Zhe Zhao, Shijie Tan, Chunping Lv, Quansheng Zhou
Publikováno v:
Toxicology and Applied Pharmacology. 365:1-8
Lung cancer is a leading lethal disease with a 5-year survival rate of only 16%. Inadequate potent anti-cancer drugs appear to be a bottleneck in the treatment of lung cancer; hence, how to develop effective anti-lung cancer therapeutics is an urgent
Publikováno v:
Biochimica et biophysica acta. Reviews on cancer. 1876(1)
Increasing evidence shows that numerous cancer-testis antigens (CTAs) are uniquely overexpressed in various types of cancer and most CTAs are oncogenic. Overexpression of oncogenic CTAs promotes carcinogenesis, cancer metastasis, and drug resistance.
Autor:
Jindan Qi, Shufen Xiang, Tong Zhang, Quansheng Zhou, Mengli Zhang, Yijun Wei, Mei Meng, Jun Yao, Xiaohua Wang, Zhe Zhao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in several cancer types. SAV1 deficiency in cells promotes tumorigenesis and cancer meta
Publikováno v:
European Journal of Pharmacology. 818:593-603
Various aggressive cancers, including pancreatic cancer, produce functional blood vessels by neovascularization. Tumor vasculogenic mimicry (VM) promotes cancer progression and is closely associated with the poor prognosis of the cancer patients. The
Autor:
Zhiguo Wang, Paul Schimmel, Fei Hong, Xiaoling Xu, Xiang-Lei Yang, My-Nuong Vo, Kanaha Nakamura, Huihao Zhou, Wanqiang Niu, Xiaolin Xiong, Keisuke Wakasugi, Quansheng Zhou
Publikováno v:
RNA Biology
Tryptophanyl-tRNA synthetase (TrpRS) in vertebrates contains a N-terminal extension in front of the catalytic core. Proteolytic removal of the N-terminal 93 amino acids gives rise to T2-TrpRS, which has potent anti-angiogenic activity mediated throug
Publikováno v:
Toxicology Letters. 278:9-17
Lyn is a proto-oncogene overexpressed and constitutively activated in lymphoma, and plays an important role in lymphoma initiation and malignant progression. Hence, the oncogenic Lyn has recently been targeted for novel anti-lymphoma drug discovery;
Autor:
Zhe Zhao, Tong Zhang, Yingnan Qiao, Mei Meng, Jindan Qi, Xiaohua Wang, Bin Zhang, Quansheng Zhou, Shijie Tan, Mengli Zhang
Publikováno v:
Biochemical Pharmacology. 185:114423
Metastatic melanoma has a very high mortality rate despite the availability of chemotherapy, radiotherapy, and immunotherapy; therefore, more effective therapeutics are needed. The Hippo pathway plays an inhibitory role in melanoma progression, but t