Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Onyee Chan"'
Autor:
Andrew T. Kuykendall, Qianxing Mo, David A. Sallman, Najla Al Ali, Onyee Chan, Seongseok Yun, Kendra L. Sweet, Eric Padron, Jeffrey E. Lancet, Rami S. Komrokji
Publikováno v:
Cancer. 128:3495-3501
Thrombocytopenia in patients with myelofibrosis (MF) is prognostically detrimental and poses a therapeutic challenge. MF patients with thrombocytopenia are considered high-risk by most prognostic models and their distinct phenotype has given rise to
Autor:
Franco Castillo Tokumori, Najla Al Ali, Onyee Chan, David Sallman, Seongseok Yun, Kendra Sweet, Eric Padron, Jeffrey Lancet, Rami Komrokji, Andrew T. Kuykendall
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:e521-e525
Up to 20% of patients with myeloproliferative neoplasms (MPN) will progress to blast phase (MPN-BP). Outcomes are dismal, with intensive chemotherapy providing little benefit. Low-intensity therapy is preferred due to better tolerability, but the pro
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:e467-e476
Genetic alterations are increasingly being recognized to play an important role in both diagnosis and prognosis of MDS. In general, MDS patients with SF3B1 mutations (MT) are known to have favorable outcomes whereas those with TP53 mutations have dis
Autor:
Rami S. Komrokji, Avani M. Singh, Najla Al Ali, Onyee Chan, Eric Padron, Kendra Sweet, Andrew Kuykendall, Jeffrey E. Lancet, David A. Sallman
Publikováno v:
Blood Cancer Journal. 12
Autor:
Andrew T. Kuykendall, David A. Sallman, Rami S. Komrokji, Najla Al Ali, David M Swoboda, Eric Padron, Onyee Chan, Virginia O. Volpe
Publikováno v:
Blood. 138:989-992
Komrokji et al examined the proposed international working group proposal to designate SF3B1-mutant myelodysplastic syndrome (MDS) as a unique disease entity, using a single-institution validation cohort of 1779 MDS patients, of whom 320 harbored SF3
Autor:
Amy E. DeZern, Alan F. List, Jeffrey E. Lancet, Hannah Newman, Eric Padron, Maria E. Balasis, Mikkael A. Sekeres, Rami S. Komrokji, Anthony M. Hunter, Qianxing Mo, Traci Kruer, Sandrine Niyongere, Markus Ball, Christopher Letson, Aaron T. Gerds, Gail J. Roboz, David A. Sallman, Hailing Zhang, Onyee Chan, David P. Steensma, William Dominguez-Viqueira
Publikováno v:
Clinical Cancer Research. 27:6095-6105
Purpose: Chronic myelomonocytic leukemia (CMML) is a rare leukemia characterized by peripheral monocytosis with no disease-modifying therapies. CMML cells are uniquely hypersensitive to granulocyte-macrophage colony-stimulating factor (GM-CSF) and ro
Autor:
Somedeb Ball, Luis E. Aguirre, Akriti G. Jain, Najla Al Ali, Sara M. Tinsley, Onyee Chan, Andrew T. Kuykendall, Kendra Sweet, Jeffrey E. Lancet, David A. Sallman, Mohammad Omar Hussaini, Eric Padron, Rami S. Komrokji
Publikováno v:
Leukemia research. 124
EZH2 mutations in myeloid neoplasms are loss of function type, and have been linked to poor overall survival (OS) in patients with myelodysplastic syndrome (MDS). However, the specific determinants of outcomes in EZH2-mutant (mut) MDS are not well ch
Autor:
Somedeb Ball, Todd C. Knepper, Yehuda E. Deutsch, Wassim Samra, Justin M. Watts, Terrence J. Bradley, Onyee Chan, Mohammad Omar Hussaini, Ling Zhang, Kendra L. Sweet, Andrew T. Kuykendall, Chetasi Talati, Eric Padron, Rami S. Komrokji, Jeffrey E. Lancet, David A. Sallman
Publikováno v:
CancerREFERENCES. 128(21)
Genomic landscape of extramedullary acute myeloid leukemia (EM-AML), including myeloid sarcoma (MS) and leukemia cutis (LC), is not well characterized. The potential utility of next-generation sequencing (NGS) using EM tissue is not established.In th
Autor:
Virginia O. Volpe, Najla Al Ali, Onyee Chan, Eric Padron, David A. Sallman, Andrew Kuykendall, Kendra Sweet, Jeffrey E. Lancet, Rami S. Komrokji
Publikováno v:
British journal of haematologyREFERENCES. 198(4)
Splicing factor 3B subunit 1 (SF3B1) somatic mutation in the context of therapy-related myelodysplastic syndromes (t-MDS) has not been well defined. In a large cohort of patients with MDS, those with known SF3B1 somatic mutation were compared as de n
Autor:
Rami S. Komrokji, Onyee Chan
Publikováno v:
Future Oncology. 17:1473-1481
Transforming growth factor beta (TGF-β) signaling pathway is key to hematopoiesis regulation. Increased activation of this pathway contributes to ineffective terminal erythroid differentiation in myelodysplastic syndromes (MDS). Luspatercept is a no