Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Natalia Baran"'
Autor:
Kaori Saito, Kotoko Yamatani, Yoko Tabe, Rodrigo Jacamo, Joseph R. Marszalek, Vivian Ruvolo, Natalia Baran, Kaori Moriya, Takashi Miida, Tianyu Cai, Haeun Yang, Vinitha Mary Kuruvilla, Tomohiko Ai, Sonoko Kinjo, Michael Andreeff, Helen Ma, Koya Suzuki, Marina Konopleva, Qi Zhang, Kazuho Ikeo, Yong-Mi Kim, Christopher P. Vellano, Junichi Imoto
Publikováno v:
Blood Advances. 5:4233-4255
Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation (OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen availability in the bone marrow (BM) microenvironment. We investigated how t
Autor:
Nedyalko Petrov, Junjun Lu, Ana Karen Nunez Cortes, Mustafa H Bdiwi, Matthew S. McNeill, Lorenzo Brunetti, Li Li, Gonca Ozcan, Nobuhiko Imahashi, Ken Chen, Mollie S. Schubert, Duncan Mak, Lucila Nassif Kerbauy, Mark A. Behlke, Luis Muniz-Feliciano, Leiser Silva, Elizabeth J. Shpall, Enli Liu, Ali Rezvan, Natalie W. Fowlkes, Elif Gokdemir, Garrett R. Rettig, Richard Skinner, Xin Ru Jiang, Jing Wang, Vakul Mohanty, Mohsen Fathi, Yifei Shen, Yuanxin Xi, Mayela Mendt, Shahram Kordasti, Natalia Baran, Francesca Lorraine Wei Inng Lim, Nadima Uprety, Sonny Ang, Sunil Acharya, Pinaki P. Banerjee, Marina Konopleva, May Daher, Richard E. Champlin, Gavin Kurgan, Heng Li, Hila Shaim, Rolf Turk, Mecit Kaplan, Xinhai Wan, Mayra Shanley, Emily Ensley, David Marin, Rafet Basar, Navin Varadarajan, Shangrong Lyu, Katayoun Rezvani, Ye Li, Vandana Nandivada
Publikováno v:
2021, ' Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells ', Blood, vol. 137, no. 5, pp. 624–636 . https://doi.org/10.1182/blood.2020007748
Immune checkpoint therapy has resulted in remarkable improvements in the outcome for certain cancers. To broaden the clinical impact of checkpoint targeting, we devised a strategy that couples targeting of the cytokine-inducible Src homology 2–cont
Autor:
Michal Mikula, Katarzyna Piwocka, Jolanta Wozniak, Ewa Jabłońska, Elżbieta Patkowska, Eliza Glodkowska-Mrowka, Patryk Górniak, Agnieszka Kolkowska-Lesniak, Przemyslaw Juszczynski, Natalia Baran, Marta Stojak, Karolina Piechna, Ewa Lech-Marańda, Beata Krzymieniewska, Lukasz Bugajski, Monika Noyszewska-Kania, Maciej Szydlowski, Anna Polak, Ewelina Kaniuga, Emilia Bialopiotrowicz, Magdalena Cybulska, Joanna Barankiewicz
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
Spleen tyrosine kinase (SYK) is an important oncogene and signaling mediator activated by cell surface receptors crucial for acute myeloid leukemia (AML) maintenance and progression. Genetic or pharmacologic inhibition of SYK in AML cells leads to in
Autor:
Svetlana B. Panina, Jingqi Pei, Natalia Baran, Elissa Tjahjono, Shraddha Patel, Gheath Alatrash, Sergej Konoplev, Leonid A. Stolbov, Vladimir V. Poroikov, Marina Konopleva, Natalia V. Kirienko
Publikováno v:
Leukemia. 36(8)
Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation. We identified six mitochondria-affecting compounds (P
Autor:
Lara Gales, Camille Montersino, Marc Conti, Pierre Bories, Courtney D. DiNardo, Brandon Nicolay, Fabien Jourdan, Nicolas Broin, Mohsen Hosseini, Guillaume Cognet, Yves Gibon, Marie Sabatier, Tony Kaoma, Marina Konopleva, Lucille Stuani, Mathilde Gotanègre, Christian Recher, Laurent Fernando, Vera Pancaldi, Nathalie Poupin, Estelle Saland, Jean-Emmanuel Sarry, Joseph R. Marszalek, Andrei Turtoi, Thomas Farge, Feng Wang, Yves Collette, Laurent Le Cam, Madi Y. Cissé, Cédric Cassan, Alexis Hucteau, Claudie Bosc, Natalia Baran, Sebastien Ronseaux, Aliki Zavoriti, François Fenaille, Florence Castelli, Laetitia K. Linares, Evgenia Turtoi, Emeline Chu-Van, Martin Carroll, Pierre-Luc Mouchel, Mary A. Selak, Guillaume Cazals, Emeline Boet, Rémy Castellano, Floriant Bellvert, Norbert Vey, Clément Larrue, Koichi Takahashi, Ambrine Sahal, Sylvain Loric, Jean-Charles Portais
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (5), ⟨10.1084/jem.20200924⟩
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (5), ⟨10.1084/jem.20200924⟩
The Journal of Experimental Medicine
Stuani et al. demonstrate that IDH mutant AML cells display an enhanced mitochondrial phenotype, which is not reversed by IDH mutant inhibitors. This study provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb2b30f8b948c067d643d1119fbb0e
https://amu.hal.science/hal-03563454/file/jStuani_em_20200924.pdf
https://amu.hal.science/hal-03563454/file/jStuani_em_20200924.pdf
Autor:
Natalia V. Kirienko, Marina Konopleva, Natalia Baran, S. B. Panina, Fabio Henrique Brasil da Costa
Publikováno v:
Cell Death and Disease, Vol 10, Iss 8, Pp 1-15 (2019)
Cell Death & Disease
Cell Death & Disease
Mitochondria play a central and multifunctional role in the progression of tumorigenesis. Although many recent studies have demonstrated correlations between mitochondrial function and genetic makeup or originating tissue, it remains unclear why some
Autor:
Sujan Piya, Yaling Yang, Seemana Bhattacharya, Priyanka Sharma, Huaxian Ma, Hong Mu, Hua He, Vivian Ruvolo, Natalia Baran, R. Eric Davis, Abhinav K. Jain, Marina Konopleava, Hagop Kantarjian, Michael Andreeff, M. James You, Gautam Borthakur
Publikováno v:
Leukemia. 36(5)
The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic leukemia (T-ALL) but a common pathway to target this circuit is poorly defined. Bro
Autor:
Marina Konopleva, Shao Cong Sun, Xuhong Cheng, Chun Jung Ko, Natalia Baran, Zuliang Jie, Tianxiao Gao, Yanchuan Li, Sung Yun Jung, Lele Zhu, Jin-Young Yang, Antrix Jain, Xiaoping Xie
Publikováno v:
Blood
B-cell–activating factor (BAFF) mediates B-cell survival and, when deregulated, contributes to autoimmune diseases and B-cell malignancies. The mechanism connecting BAFF receptor (BAFFR) signal to downstream pathways and pathophysiological function
Autor:
Marina Konopleva, Natalia Baran
Publikováno v:
Clinical Cancer Research. 23:2382-2390
Hypoxia is a known feature of aggressive solid tumors as well as a critical hallmark of the niche in aggressive hematologic malignances. Hypoxia is associated with insufficient response to standard therapy, resulting in disease progression and curtai
Autor:
Yimin Qian, Vivian Ruvolo, Seemana Bhattacharya, Sujan Piya, Michael Andreeff, Marina Konopleva, R. Eric Davis, Philip L. Lorenzi, Hong Mu, Teresa McQueen, Hagop M. Kantarjian, Natalia Baran, M. James You, Gautam Borthakur, Zhiqiang Wang, Jo Ishizawa, Craig M. Crews
Publikováno v:
The Journal of clinical investigation. 129(5)
The antileukemic effect of inhibiting bromodomain and extra-terminal domain-containing (BET-containing) proteins (BETPs) such as BRD4 has largely been largely attributed to transcriptional downregulation of cellular anabolic and antiapoptotic process