Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Michael E Wechsler"'
Autor:
Michael E, Wechsler, Amy D, Klion, Pierluigi, Paggiaro, Parameswaran, Nair, Delphine, Staumont-Salle, Amr, Radwan, Robert R, Johnson, Upender, Kapoor, Faisal A, Khokhar, Nadia, Daizadeh, Zhen, Chen, Elizabeth, Laws, Benjamin, Ortiz, Juby A, Jacob-Nara, Leda P, Mannent, Paul J, Rowe, Yamo, Deniz
Publikováno v:
The Journal of Allergy and Clinical Immunology: In Practice. 10:2695-2709
Transient increases in blood eosinophil counts have been observed in dupilumab clinical trials.To assess eosinophil counts and eosinophilia-related treatment-emergent adverse events (TEAEs) across 11 dupilumab clinical trials, comparing adult and ado
Autor:
Flavia C L, Hoyte, Giselle S, Mosnaim, Linda, Rogers, Guilherme, Safioti, Randall, Brown, Thomas, Li, Michael, DePietro, Michael, Reich, Tanisha D, Hill, Michael E, Wechsler
Publikováno v:
The Journal of Allergy and Clinical Immunology: In Practice. 10:2579-2587
The albuterol Digihaler (albuterol 90 μg/dose) transmits data wirelessly to a smart device application, which synchronizes with a Digital Health Platform to store and transfer data to a web-based Dashboard. The Reliever Digihaler System (RDS) compri
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 206:644-648
Autor:
Mario Castro, David T. Mauger, Tonya S. King, Christine A. Sorkness, Sally E. Wenzel, Njira L Lugogo, Juan Carlos Cardet, Wanda Phipatanakul, Kathryn V. Blake, Ronina A. Covar, Jason E. Lang, Jerry A. Krishnan, Stephen C. Lazarus, Anne-Marie Dyer, Michael E. Wechsler, Elliot Israel
Publikováno v:
Ann Am Thorac Soc
RATIONALE: Whether biomarkers can be used to predict response to inhaled corticosteroids (ICS) or long-acting muscarinic antagonists (LAMA) in mild persistent asthma is unclear. OBJECTIVES: In a prespecified exploratory analysis of a randomized clini
Publikováno v:
Chest. 160:2019-2029
A 56-year-old man has difficult-to-control asthma and a history of four exacerbations in the prior 12 months despite high-dose inhaled corticosteroids (ICS) and additional controller therapies. Is he suitable for more advanced therapeutic options? To
Autor:
Claire Emson, Sally E. Wenzel, Jane R. Parnes, James Johnston, Sarah Diver, Christopher E. Brightling, Latifa Khalfaoui, Ayman Megally, Nestor Molfino, Michael E. Wechsler, Gene L. Colice, Andrew Menzies-Gow
Publikováno v:
The Lancet Respiratory Medicine. 9:1299-1312
Summary Background Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. In phase 2b and 3 studies, tezepelumab significantly reduced exacerbations versus plac
Autor:
Helene Goulaouic, Michael E. Wechsler, Andreas Jessel, George D. Yancopoulos, Elliot Israel, Ian D. Pavord, Jorge Maspero, Nikhil Amin, Linda B. Ford, Klaus F. Rabe, Marcella Ruddy, Michael C Nivens, David M. Weinreich, Chih-Chi Hu, Renata Martincova, Raolat M Abdulai
Publikováno v:
New England Journal of Medicine. 385:1656-1668
Monoclonal antibodies targeting IgE, interleukin-4 and -13, and interleukin-5 are effective in treating severe type 2 asthma, but new targets are needed. Itepekimab is a new monoclonal antibody against the upstream alarmin interleukin-33. The efficac
Autor:
Peter A. Merkel, Stephanie K. Dougan, Ariel Munitz, Michael E. Wechsler, Florence Schleich, Matthew G. Drake, Charlene M. Prazma, Pascal Chanez, Peter H. Howarth, Andrew J. Wardlaw, Sergejs Berdnikovs, Andrea Matucci, David A. Jackson, Steven J. Ackerman, Peter F. Weller
Publikováno v:
Mayo Clinic Proceedings
Mayo Clinic Proceedings, 2021, 96 (10), pp.2694-2707. ⟨10.1016/j.mayocp.2021.04.025⟩
Mayo Clinic Proceedings, 2021, 96 (10), pp.2694-2707. ⟨10.1016/j.mayocp.2021.04.025⟩
International audience; Eosinophils play a homeostatic role in the body's immune responses. These cells are involved in combating some parasitic, bacterial, and viral infections and certain cancers and have pathologic roles in diseases including asth
Autor:
Michael E. Wechsler, Elliot Israel, Primal Kaur, Janet M. Griffiths, Christopher E. Brightling, Arnaud Bourdin, Andrew Menzies-gow, Gene L. Colice, Geoffrey Chupp, Gun Almqvist, Jonathan Corren, Karin Bowen, Sandhia Ponnarambil, Åsa Hellqvist
Publikováno v:
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
International audience; BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patient
Publikováno v:
Chest
The clinical research we do to improve our understanding of disease and to develop new therapies has temporarily been delayed as the global health-care enterprise has focused its attention on those impacted by coronavirus disease 2019 (COVID-19). Alt