Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Melissa Sorosina"'
Autor:
Federica Esposito, Ana Maria Osiceanu, Melissa Sorosina, Linda Ottoboni, Bryan Bollman, Silvia Santoro, Barbara Bettegazzi, Andrea Zauli, Ferdinando Clarelli, Elisabetta Mascia, Andrea Calabria, Daniele Zacchetti, Ruggero Capra, Maurizio Ferrari, Paolo Provero, Dejan Lazarevic, Davide Cittaro, Paola Carrera, Nikolaos Patsopoulos, Daniela Toniolo, A Dessa Sadovnick, Gianvito Martino, Philip L. De Jager, Giancarlo Comi, Elia Stupka, Carles Vilariño-Güell, Laura Piccio, Filippo Martinelli Boneschi
Publikováno v:
Genes; Volume 13; Issue 12; Pages: 2392
While the role of common genetic variants in multiple sclerosis (MS) has been elucidated in large genome-wide association studies, the contribution of rare variants to the disease remains unclear. Herein, a whole-genome sequencing study in four affec
Autor:
Giacomo Sferruzza, Ferdinando Clarelli, Elisabetta Mascia, Laura Ferrè, Linda Ottoboni, Melissa Sorosina, Silvia Santoro, Massimo Filippi, Paolo Provero, Federica Esposito
Publikováno v:
Pharmacogenomics. 23:161-171
Aim: To investigate the transcriptional changes induced by Fingolimod (FTY) in T cells of relapsing remitting multiple sclerosis patients. Patients & methods: Transcriptomic changes after 6 months of FTY therapy were evaluated on T cells from 24 rela
Autor:
Melissa Sorosina, Ferdinando Clarelli, P. Provero, G. Comi, F. Martinelli Boneschi, Laura Ferrè, Federica Esposito, Massimo Filippi, Elisabetta Mascia, Linda Ottoboni, Giacomo Sferruzza, Silvia Santoro, Lucia Moiola, Vittorio Martinelli
Publikováno v:
Molecular Neurobiology. 58:4816-4827
Fingolimod (FTY), a second-line oral drug approved for relapsing remitting Multiple Sclerosis (RRMS) acts in preventing lymphocyte migration outside lymph nodes; moreover, several lines of evidence suggest that it also inhibits myeloid cell activatio
Autor:
Laura Ferrè, Maria A. Rocca, Federica Esposito, Ermelinda De Meo, Melissa Sorosina, Filippo Martinelli Boneschi, Silvia Santoro, Massimo Filippi, Ferdinando Clarelli
Publikováno v:
European Journal of Neurology. 28:2513-2522
BACKGROUND AND PURPOSE Multiple sclerosis (MS) susceptibility is influenced by genetics; however, little is known about genetic determinants of disease expression. We aimed at assessing genetic factors influencing quantitative neuroimaging measures i
Autor:
Melissa, Sorosina, Nadia, Barizzone, Ferdinando, Clarelli, Santosh, Anand, Sara, Lupoli, Erika, Salvi, Eleonora, Mangano, Roberta, Bordoni, Tina, Roostaei, Elisabetta, Mascia, Miriam, Zuccalà, Domizia, Vecchio, Paola, Cavalla, Silvia, Santoro, Laura, Ferrè, Alen, Zollo, Cristina, Barlassina, Daniele, Cusi, Vittorio, Martinelli, Giancarlo, Comi, Maurizio, Leone, Massimo, Filippi, Nikolaos A, Patsopoulos, Philip L, De Jager, Gianluca, De Bellis, Federica, Esposito, Sandra, D'Alfonso, Maria, Trojano
Publikováno v:
Journal of neurology. 269(8)
Over 200 genetic loci have been associated with multiple sclerosis (MS) explaining ~ 50% of its heritability, suggesting that additional mechanisms may account for the "missing heritability" phenomenon.To analyze a large cohort of Italian individuals
Autor:
Cristoforo Comi, Filippo Martinelli-Boneschi, Lucia Corrado, Rachele Cagliani, Martina Tosi, Cristina Agliardi, Francesco Favero, Giancarlo Comi, Nadia Barizzone, Melissa Sorosina, Massimo Filippi, Ferdinando Clarelli, Davide Corà, Domenico Caputo, Elisabetta Mascia, Manuela Sironi, Maria Liguori, Chiara Basagni, Vittorio Martinelli, Domizia Vecchio, Miriam Zuccalà, Federica Esposito, Maurizio Leone, Diego Forni, Sandra D'Alfonso, Franca Rosa Guerini, Laura Mendozzi
Publikováno v:
Genes, Vol 12, Iss 1607, p 1607 (2021)
Genes (Basel) (2021). doi:10.3390/genes12101607
info:cnr-pdr/source/autori:Nadia Barizzone, Rachele Cagliani, Chiara Basagni, Ferdinando Clarelli, Laura Mendozzi, Cristina Agliardi, Diego Forni, Martina Tosi, Elisabetta Mascia, Francesco Favero, Davide Corà, Lucia Corrado, Melissa Sorosina, Federica Esposito, Miriam Zuccalà, Domizia Vecchio, Maria Liguori, Cristoforo Comi, Giancarlo Comi, Vittorio Martinelli, Massimo Filippi, Maurizio Leone, Filippo Martinelli-Boneschi, Domenico Caputo, Manuela Sironi, Franca Rosa Guerini and Sandra D'Alfonso/titolo:An Investigation of the Role of Common and Rare Variants in a Large Italian Multiplex Family of Multiple Sclerosis Patients/doi:10.3390%2Fgenes12101607/rivista:Genes (Basel)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Genes
Volume 12
Issue 10
Genes (Basel) (2021). doi:10.3390/genes12101607
info:cnr-pdr/source/autori:Nadia Barizzone, Rachele Cagliani, Chiara Basagni, Ferdinando Clarelli, Laura Mendozzi, Cristina Agliardi, Diego Forni, Martina Tosi, Elisabetta Mascia, Francesco Favero, Davide Corà, Lucia Corrado, Melissa Sorosina, Federica Esposito, Miriam Zuccalà, Domizia Vecchio, Maria Liguori, Cristoforo Comi, Giancarlo Comi, Vittorio Martinelli, Massimo Filippi, Maurizio Leone, Filippo Martinelli-Boneschi, Domenico Caputo, Manuela Sironi, Franca Rosa Guerini and Sandra D'Alfonso/titolo:An Investigation of the Role of Common and Rare Variants in a Large Italian Multiplex Family of Multiple Sclerosis Patients/doi:10.3390%2Fgenes12101607/rivista:Genes (Basel)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Genes
Volume 12
Issue 10
Known multiple sclerosis (MS) susceptibility variants can only explain half of the disease’s estimated heritability, whereas low-frequency and rare variants may partly account for the missing heritability. Thus, here we sought to determine the occu
Autor:
Melissa Sorosina, Silvia Peroni, Elisabetta Mascia, Silvia Santoro, Ana Maria Osiceanu, Laura Ferrè, Ferdinando Clarelli, Antonino Giordano, Miryam Cannizzaro, Filippo Martinelli Boneschi, Massimo Filippi, Federica Esposito
Publikováno v:
Genes; Volume 13; Issue 11; Pages: 1946
Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder of the central nervous system (CNS). The migration of immune cells into the CNS is essential for its development, and plasma membrane molecules play an important role in triggering
Autor:
Ferdinando Clarelli, S. Bonfiglio, Massimo Filippi, Federica Esposito, A. Protti, Giulia Barbiera, Filippo Martinelli-Boneschi, Vittorio Martinelli, E. Stupka, Silvia Santoro, Elisabetta Mascia, Clara Guaschino, Francesca Giannese, Melissa Sorosina, Dejan Lazarevic, Jose Manuel Garcia-Manteiga, Davide Cittaro
Publikováno v:
Journal of neuroimmunology. 356
Multiple Sclerosis (MS) is caused by a still unknown interplay between genetic and environmental factors. Epigenetics, including DNA methylation, represents a model for environmental factors to influence MS risk. Twenty-six affected and 26 unaffected
Autor:
Maurizio Leone, Alberto Gajofatto, Roberta Bordoni, Domizia Vecchio, Claudio Solaro, Santosh Anand, Eleonora Mangano, Elena Corsetti, Elena Boggio, Umberto Dianzani, Serena Martire, Daniela Ferrante, Andrei Ivashynka, Sandra D'Alfonso, Roberto Cantello, Vittorio Martinelli, Melissa Sorosina, F. Esposito, Giancarlo Comi, Chiara Basagni, Gianluca De Bellis, Luca Gigliotti, Ferdinando Clarelli, Filippo Martinelli-Boneschi, Massimo Filippi, Simona Perga, Miriam Zuccalà, Nadia Barizzone
Publikováno v:
Journal of genetics and genomics = Yi chuan xue bao. 48(6)
Among multiple sclerosis (MS) susceptibility genes, the strongest non-human leukocyte antigen (HLA) signal in the Italian population maps to the TNFSF14 gene encoding LIGHT, a glycoprotein involved in dendritic cell (DC) maturation. Through fine-mapp
Autor:
Filippo Martinelli Boneschi, Raffaella Lombardi, Margherita Marchi, Silvia Peroni, Giancarlo Comi, Ignazio Diego Lopez, Ferdinando Clarelli, Silvia Santoro, Andrea Zauli, Ana Maria Osiceanu, Daniele Cazzato, Angelo Quattrini, Melissa Sorosina, Raffaele A. Calogero, Giuseppe Lauria
Publikováno v:
BMC Molecular Biology, Vol 19, Iss 1, Pp 1-11 (2018)
BMC Molecular Biology
BMC Molecular Biology
Background The acquisition of reliable tissue-specific RNA sequencing data from human skin biopsy represents a major advance in research. However, the complexity of the process of isolation of specific layers from fresh-frozen human specimen by laser