Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Matthew Trotter"'
Autor:
Brian S. White, Mehmet Kemal Samur, Alexander V. Ratushny, Michael Mason, Gareth J. Morgan, Justin Guinney, Yi Cui, Pieter Sonneveld, Bailiang Li, Carolina Schinke, Fadi Towfic, Samuel A. Danziger, Hervé Avet-Loiseau, Matthew Trotter, Elias Chaibub Neto, Hongyue Y Dai, Valeriy V. Lyzogubov, Christine Eng, Jonathan Göke, Anjan Thakurta, Hongjie Chen, Andrew Dervan, William S. Dalton, Daniel Auclair, Douglas Bassett, Nikhil C. Munshi, Kenneth H. Shain, Fred K. Gruber, Boris Hayete, Brian A Walker, Aditya Pratapa, Frank Schmitz, Hartmut Goldschmidt, Thomas Yu, Dirk Hose, Erin Flynt, Kamlesh Bisht, Maria Ortiz, Yuanfang Guan, Konstantinos Mavrommatis, Dan Rozelle
Publikováno v:
Leukemia 34, 1866–1874 (2020)
Leukemia
Leukemia
While the past decade has seen meaningful improvements in clinical outcomes for multiple myeloma patients, a subset of patients do not benefit from current therapeutics for unclear reasons. Many gene expression-based models of risk have been develope
Autor:
Matthew Trotter, Jing Ai, Peter H. Schafer, Matthew E. Stokes, Irina V. Medvedeva, Robert Yang, Dominic Eisinger, Samuel T. Labrie
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Finding biomarkers that provide shared link between disease severity, drug-induced pharmacodynamic effects and response status in human trials can provide number of values for patient benefits: elucidating current therapeutic mechanism-of-action, and
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Hongwei Wang, Matthew Trotter, John C. Obenauer, Michael A Bauer, Kenneth C. Anderson, Brian A Walker, Zhinuan Yu, Pingping Qu, Zhihong Yang, T. Cody Ashby, Erin Flynt, Nikhil C. Munshi, Mariateresa Fulciniti, Mehmet Kemal Samur, A. Keith Stewart, Konstantinos Mavrommatis, Gareth J. Morgan, Dan Rozelle, Antje Hoering, Daniel Auclair, Brian G.M. Durie, Pieter Sonneveld, Hermann Einsele, Adam Rosenthal, Maria Ortiz, Marc S. Raab, Niccolo Bolli, Graham Jackson, Faith E. Davies, Fadi Towfic, Hartmut Goldschmidt, Jonathan J Keats, Christopher P. Wardell, Raphael Szalat, Hervé Avet-Loiseau, Anjan Thakurta, Jesús F. San Miguel, Sagar Lonial, P. Moreau
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Leukemia, 33(1), 159-170. Nature Publishing Group
Leukemia
Oncotarget
instname
Leukemia, 33(1), 159-170. Nature Publishing Group
Leukemia
Oncotarget
Patients with newly diagnosed multiple myeloma (NDMM) with high-risk disease are in need of new treatment strategies to improve the outcomes. Multiple clinical, cytogenetic, or gene expression features have been used to identify high-risk patients, e
Autor:
Mark McConnell, Samuel A. Danziger, Boris Aguilar, David J. Reiss, Matthew Trotter, Alexander V. Ratushny, Andrew Dervan, Robert M. Hershberg, Ilya Shmulevich, Douglas Bassett, David L Gibbs
Publikováno v:
GigaScience
Background Mechanistic models, when combined with pertinent data, can improve our knowledge regarding important molecular and cellular mechanisms found in cancer. These models make the prediction of tissue-level response to drug treatment possible, w
Autor:
Matthew Trotter, Cesare Galli, Silvia Colleoni, Giovanna Lazzari, Maria Barandalla, Pietro Liò, Hui Shi, Hui Xiao
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-16 (2017)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Human embryonic stem cells (hESCs) potentially offer new routes to study, on the basis of the Developmental Origins of Health and Disease (DOHaD) concept, how the maternal environment during pregnancy influences the offspring’s health an
Autor:
Andrew Dervan, Matthew Trotter, Christopher Mark Hill, Brian Fox, Hamid Bolouri, Alexander V. Ratushny, Anne-Renee van der Vuurst de Vries, Joshua Beilke, Pallavur Sivakumar, Paul Shannon, Rebecca Johnson, Mary Young, Lu Huang, Douglas Bassett, C.C. Santini
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Failure to clear antigens causes CD8+ T cells to become increasingly hypo-functional, a state known as exhaustion. We combined manually extracted information from published literature with gene expression data from diverse model systems to infer a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c710102aeb2ce4874d47ec577d38fe37
Autor:
Aneta, Mikulasova, Cody, Ashby, Ruslana G, Tytarenko, Pingping, Qu, Adam, Rosenthal, Judith A, Dent, Katie R, Ryan, Michael A, Bauer, Christopher P, Wardell, Antje, Hoering, Konstantinos, Mavrommatis, Matthew, Trotter, Shayu, Deshpande, Shmuel, Yaccoby, Erming, Tian, Jonathan, Keats, Daniel, Auclair, Graham H, Jackson, Faith E, Davies, Anjan, Thakurta, Gareth J, Morgan, Brian A, Walker
Publikováno v:
Haematologica
MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood. We sho
Autor:
Remco Loos, J. De Las Rivas, Maria Ortiz-Estevez, Matthew Trotter, Celia Fontanillo, Jose Manuel Sanchez-Santos, Beatriz Roson-Burgo, Alberto Risueño, Conrad Droste, Francisco J. Campos-Laborie
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Bioinformatics
instname
Bioinformatics
[Motivation]: Patient and sample diversity is one of the main challenges when dealing with clinical cohorts in biomedical genomics studies. During last decade, several methods have been developed to identify biomarkers assigned to specific individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb61eabd7be03f83249150aa0fe1cf
http://hdl.handle.net/10261/203050
http://hdl.handle.net/10261/203050
Autor:
Frank Schmitz, Samuel A. Danziger, Mark McConnell, David J. Reiss, Ilya Shmulevich, David L Gibbs, Matthew Trotter, Alexander V. Ratushny
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224693 (2019)
PLoS ONE
PLoS ONE
Immune cell infiltration of tumors can be an important component for determining patient outcomes, e.g. by inferring immune cell presence by deconvolving gene expression data drawn from a heterogenous mix of cell types. One particularly powerful fami