Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maike, Bublitz"'
Autor:
Maxwell M G, Geurts, Johannes D, Clausen, Bertrand, Arnou, Cédric, Montigny, Guillaume, Lenoir, Robin A, Corey, Christine, Jaxel, Jesper V, Møller, Poul, Nissen, Jens Peter, Andersen, Marc, le Maire, Maike, Bublitz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We present a crystal structure, functional data, and molecular dynamics (MD) simulations of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) mutant E340A. The mutation slows Ca2+-binding kinetics, and the structural differences betwe
Autor:
Maike Bublitz, William Dalby-Brown, Franco Aversa, Paolo Sportoletti, Anne-Marie Lund Winther, Marilena Baglione, Giorgia Rastelli, Chiara Rompietti, Rocchina Vilella, Donatella Stilli, Caterina Loiacono, Federica Rizzi, Samuel Kitara, Luca Pagliaro, Giovanni Roti, Andrea Gherli, Claus Olesen, Anna Montanaro, Roberta La Starza, Monia Savi, Matteo Marchesini, Leonardo Bocchi, Cristina Mecucci, Laura Patrizi, Sabine Heit, Claudia Sorrentino, Jesper V. Møller, Kimberly Stegmaier
Publikováno v:
Cell Chem Biol
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002
Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, C E, Møller, J V, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A M, Sportoletti, P, Bublitz, M, Dalby-Brown, W & Roti, G 2020, ' Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia ', Cell Chemical Biology, vol. 27, no. 6, pp. 678-697.e13 . https://doi.org/10.1016/j.chembiol.2020.04.002
The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e63576c860546d9cf10c8571266edb
https://doi.org/10.1016/j.chembiol.2020.04.002
https://doi.org/10.1016/j.chembiol.2020.04.002
Autor:
William Dalby-Brown, Anne-Marie Lund Winther, Johannes D. Clausen, Thomas David Pallin, Anne Louise Mortensen, Karen O'Hanlon Cohrt, Maike Bublitz, John Bondo Hansen, Anja T. Fuglsang, Lasse Kjellerup, Sandra Gordon
Publikováno v:
PLoS ONE
Bublitz, M, Kjellerup, L, Cohrt, K OH, Gordon, S, Mortensen, A L, Clausen, J D, Pallin, T D, Hansen, J B, Fuglsang, A T, Dalby-Brown, W & Winther, A-M L 2018, ' Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity ', PLOS ONE, vol. 13, no. 1, e0188620 . https://doi.org/10.1371/journal.pone.0188620
PLoS ONE, Vol 13, Iss 1, p e0188620 (2018)
Bublitz, M, Kjellerup, L, Cohrt, K OH, Gordon, S, Mortensen, A L, Clausen, J D, Pallin, T D, Hansen, J B, Fuglsang, A T, Dalby-Brown, W & Winther, A-M L 2018, ' Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity ', PLOS ONE, vol. 13, no. 1, e0188620 . https://doi.org/10.1371/journal.pone.0188620
PLoS ONE, Vol 13, Iss 1, p e0188620 (2018)
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data and computation
Autor:
Ole G. Mouritsen, Hanne Poulsen, J. Preben Morth, Himanshu Khandelia, Jan Egebjerg, Maike Bublitz, Poul Nissen
Publikováno v:
Poulsen, H, Khandelia, H, Morth, J P, Bublitz, M, Mouritsen, O G, Egebjerg, J & Nissen, P 2010, ' Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase ', Nature, vol. 467, no. 7311, pp. 99-102 . https://doi.org/10.1038/nature09309
Nature
Nature
The Na+/K+-ATPase enzyme pumps three sodium ions out of the cell and two potassium ions into the cell while splitting a single molecule of ATP. This process generates the chemical gradients across the plasma membrane that are essential to electrical
Autor:
Thomas R. M. Barends, Garth J. Williams, Wolfgang Kabsch, Jonas Lindholt Gregersen, Daniel Mattle, Poul Nissen, Roberto Alonso-Mori, Stefan P. Hau-Riege, Saša Bajt, H. Olof Jönsson, Carl Caleman, Jason E. Koglin, Sébastien Boutet, Nikolaj D. Drachmann, Sabine Botha, Stephan Kassemeyer, Oleg Sitsel, Ilme Schlichting, Michael Krumrey, Marc Messerschmidt, Henry N. Chapman, Kenneth R. Beyerlein, Lutz Foucar, Anton Barty, Nicusor Timneanu, Dimosthenis Sokaras, Elisabeth Hartmann, Karol Nass, Andrew Aquila, Maike Bublitz, R. Bruce Doak, Richard Bean, Robert L. Shoeman, Linda Reinhard
Publikováno v:
Nass, K, Foucar, L, Barends, T R M, Hartmann, E, Botha, S, Shoeman, R L, Doak, R B, Alonso-Mori, R, Aquila, A, Bajt, S, Barty, A, Bean, R, Beyerlein, K R, Bublitz, M, Drachmann, N, Gregersen, J, Jönsson, H O, Kabsch, W, Kassemeyer, S, Koglin, J E, Krumrey, M, Mattle, D, Messerschmidt, M, Nissen, P, Reinhard (maiden name Schuldt), L, Sitsel, O, Sokaras, D, Williams, G J, Hau-Riege, S, Timneanu, N, Caleman, C, Chapman, H N, Boutet, S & Schlichting, I 2015, ' Indications of radiation damage in ferredoxin microcrystals using high-intensity X-FEL beams ', Journal of Synchrotron Radiation, vol. 22, no. 2, pp. 225-238 . https://doi.org/10.1107/S1600577515002349
Journal of Synchrotron Radiation
Journal of synchrotron radiation 22(2), 225-238 (2015). doi:10.1107/S1600577515002349
Journal of Synchrotron Radiation
Journal of synchrotron radiation 22(2), 225-238 (2015). doi:10.1107/S1600577515002349
Proteins that contain metal cofactors are expected to be highly radiation sensitive since the degree of X-ray absorption correlates with the presence of high-atomic-number elements and X-ray energy. To explore the effects of local damage in serial fe
Autor:
Birgit Schiøtt, Lea Thøgersen, Maria Musgaard, Poul Nissen, Jesper V. Møller, J. Preben Morth, Claus Olesen, Maike Bublitz, Hanne Poulsen
Publikováno v:
Bublitz, M, Musgaard, M, Poulsen, H, Thøgersen, L, Olesen, C, Schiøtt, B, Morth, P, Møller, J V & Nissen, P 2013, ' Ion Pathways in the Sarcoplasmic Reticulum Ca 2+-ATPase ', Journal of Biological Chemistry, vol. 288, pp. 10759-10765 . https://doi.org/10.1074/jbc.R112.436550
The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) is a transmembrane ion transporter belonging to the P(II)-type ATPase family. It performs the vital task of re-sequestering cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby als
Publikováno v:
Bublitz, M, Morth, J P & Nissen, P 2011, ' P-type ATPases at a glance ', Journal of Cell Science, vol. 124, no. Pt 15, pp. 2515-9 . https://doi.org/10.1242/jcs.088716
Journal of Cell Science
Journal of Cell Science
P-type ATPases are a large family of integral membrane transporters that are of vital importance in all kingdoms of life. In eponymous distinction from the other main classes of transport ATPase – the FF1 (F-), the vacuolar (V-) and the ATP-binding