Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kelly A. Whelan"'
Publikováno v:
Advances in experimental medicine and biology. 1360
The Growth Arrest and DNA Damage-inducible 45 (GADD45) family of proteins are critical stress sensors that mediate various cellular responses, including DNA repair, cell cycle arrest, and apoptosis. Here, we review current literature investigating GA
Autor:
Brianna Navarre, Elizabeth T. Jensen, Seema S. Aceves, Kelly A. Whelan, Michael K. Dougherty, Evan S. Dellon, Amanda B. Muir, Bailey Aaron
Publikováno v:
Clin Exp Allergy
Author(s): Muir, Amanda B; Whelan, Kelly A; Dougherty, Michael K; Aaron, Bailey; Navarre, Brianna; Aceves, Seema S; Dellon, Evan S; Jensen, Elizabeth T | Abstract: ObjectiveWhile chronic inflammation is a well-established risk factor for malignancy,
Autor:
Takeo, Hara, Yuta, Kasagi, Joshua, Wang, Masaru, Sasaki, Bailey, Aaron, Adam, Karami, Masataka, Shimonosono, Rieko, Shimonosono, Hisatsugu, Maekawa, Lauren, Dolinsky, Benjamin, Wilkins, Jeremy, Klein, Jane, Wei, Kathryn, Nunes, Kristle, Lynch, Jonathan M, Spergel, Kathryn E, Hamilton, Melanie A, Ruffner, Tatiana A, Karakasheva, Kelly A, Whelan, Hiroshi, Nakagawa, Amanda B, Muir
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 13(5)
Although basal cell hyperplasia is a histologic hallmark of eosinophilic esophagitis (EoE), little is known about the capabilities of epithelial renewal and differentiation in the EoE inflammatory milieu. In murine esophageal epithelium, there are se
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature communications. 13(1)
Although morphologic progression coupled with expression of specific molecular markers has been characterized along the esophageal squamous differentiation gradient, the molecular heterogeneity within cell types along this trajectory has yet to be cl
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 316:G197-G204
Intestinal epithelial cells are among the most rapidly proliferating cell types in the human body. There are several different subtypes of epithelial cells, each with unique functional roles in responding to the ever-changing environment. The epithel
Publikováno v:
Current Opinion in Pharmacology. 41:12-19
Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles
Autor:
Eric Z. Chen, Ramnik J. Xavier, Clary B. Clish, Stephen R. Master, Jonathan Braun, Sue A. Keilbaugh, Frederic D. Bushman, Meenakshi Bewtra, Barry Slaff, Lu Tan, Michael J. Bennett, Aalim M. Weljie, Hongzhe Li, James D. Lewis, Hiroshi Nakagawa, Kathryn E. Hamilton, Jie Chen, Sayaka A. Ogawa, Gary D. Wu, Sarah A. Smith, Franz Fogt, Kelly A. Whelan, Lillian Chau
Publikováno v:
J Clin Invest
As the interface between the gut microbiota and the mucosal immune system, there has been great interest in the maintenance of colonic epithelial integrity through mitochondrial oxidation of butyrate, a short-chain fatty acid produced by the gut micr
Autor:
Joel Gabre, Jianwen Que, Angela J. Yoon, Ricardo Cruz-Acuna, Gary W. Falk, Shoji Natsugoe, Adam J. Bass, Julian A. Abrams, Tatiana A. Karakasheva, Lorenzo Ferri, Veena Sangwan, Anil K. Rustgi, Timothy C. Wang, Hiroshi Nakagawa, Varun Sahu, Kelly A. Whelan, Gregory G. Ginsberg, Elizabeth Philipone, J. Alan Diehl, Veronique Giroux, Hisatsugu Maekawa, Andres J. Klein-Szanto, Devraj Basu, Masataka Shimonosono, Takashi Kijima
Publikováno v:
Curr Protoc Stem Cell Biol
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. Both are difficult to treat and among the deadliest human malignancies. We describe protocols to initiate, grow, passage, and characterize patie
Autor:
Bailey Aaron, Masataka Shimonosono, Dominique Bailey, Takeo Hara, Julian A. Abrams, Kathryn E. Hamilton, Yuta Kasagi, Veronique Giroux, Hiroshi Nakagawa, Jonathan M. Spergel, Gary W. Falk, Amanda B. Muir, Tatiana A. Karakasheva, Seema S. Aceves, Kelly A. Whelan, Takashi Kijima, Benjamin J. Wilkins
Publikováno v:
Curr Protoc Stem Cell Biol
The homeostatic proliferation-differentiation gradient in the esophageal epithelium is perturbed under inflammatory disease conditions such as gastroesophageal reflux disease and eosinophilic esophagitis. Herein we describe the protocols for rapid ge