Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Karch, Celeste M."'
Autor:
Vöglein, Jonathan, Franzmeier, Nicolai, Fagan, Anne, Noble, James M, Berman, Sarah B, Graff-Radford, Neill R, Ghetti, Bernardino, Farlow, Martin R, Chhatwal, Jasmeer P, Salloway, Stephen, Xiong, Chengjie, Karch, Celeste M, Morris, John C, Cairns, Nigel, Perrin, Richard J, Day, Gregory, Martins, Ralph, Sanchez-Valle, Raquel, Mori, Hiroshi, Shimada, Hiroyuki, Ikeuchi, Takeshi, Suzuki, Kazushi, Schofield, Peter R, Dieterich, Marianne, Masters, Colin L, Goate, Alison, Buckles, Virginia, Fox, Nick C, Chrem, Patricio, Allegri, Ricardo, Ringman, John M, Yakushev, Igor, Laske, Christoph, Jucker, Mathias, McDade, Eric, Höglinger, Günter, Bateman, Randall J, Danek, Adrian, Levin, Johannes, Network, Dominantly Inherited Alzheimer, Simons, Mikael, Preische, Oliver, Hofmann, Anna, Hassenstab, Jason, Benzinger, Tammie L
Publikováno v:
Alzheimer's and dementia 19(2), 632-645 (2023). doi:10.1002/alz.12684
As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ADAD.Frequencies of neurological examinati
Autor:
Morenas-Rodríguez, Estrella, Li, Yan, Hassenstab, Jason, Laske, Christoph, Levey, Allan, Lopez, Oscar, Marsh, Jacob, Martinez, Rita, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Mawuenyega, Kwasi, McCullough, Austin, McDade, Eric, Mejia, Arlene, MountzMD, James, Mummery, Cath, Nadkarni, Neelesh, Nagamatsu, Akemi, Neimeyer, Katie, Niimi, Yoshiki, Noble, James, Norton, Joanne, Nuscher, Brigitte, Feederle, Regina, O'Connor, Antoinette, Obermüller, Ulricke, Patira, Riddhi, Perrin, Richard, Ping, Lingyan, Preische, Oliver, Renton, Alan, Ringman, John, Salloway, Stephen, Schofield, Peter, Karch, Celeste M, Senda, Michio, Seyfried, Nick, Shady, Kristine, Shimada, Hiroyuki, Sigurdson, Wendy, Smith, Jennifer, Smith, Lori, Snitz, Beth, Sohrabi, Hamid, Stephens, Sochenda, Schlepckow, Kai, Taddei, Kevin, Thompson, Sarah, Wang, Peter, Wang, Qing, Weamer, Elise, Xu, Jinbin, Xu, Xiong, Morris, John C, Kleinberger, Gernot, Nellgard, Bengt, Vöglein, Jonathan, Blennow, Kaj, Zetterberg, Henrik, Ewers, Michael, Jucker, Mathias, Levin, Johannes, Bateman, Randall J, Haass, Christian, Network, Dominantly Inherited Alzheimer, Adams, Sarah, Allegri, Ricardo, Araki, Aki, Franzmeier, Nicolai, Barthelemy, Nicolas, Bechara, Jacob, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Brosch, Jared, Buck, Jill, Buckles, Virginia, Carter, Kathleen, Xiong, Chengjie, Cash, Lisa, Chen, Charlie, Chhatwal, Jasmeer, Chrem, Patricio, Chua, Jasmin, Chui, Helena, Cruchaga, Carlos, Day, Gregory S, De La Cruz, Chrismary, Denner, Darcy, Suarez-Calvet, Marc, Diffenbacher, Anna, Dincer, Aylin, Donahue, Tamara, Douglas, Jane, Duong, Duc, Egido, Noelia, Esposito, Bianca, Farlow, Marty, Feldman, Becca, Fitzpatrick, Colleen, Fagan, Anne M, Flores, Shaney, Fox, Nick, Franklin, Erin, Friedrichsen, Nelly, Fujii, Hisako, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldberg, Sarah, Goldman, Jill, Schultz, Stephanie, Gonzalez, Alyssa, Gräber-Sultan, Susanne, Graff-Radford, Neill, Graham, Morgan, Gray, Julia, Gremminger, Emily, Grilo, Miguel, Groves, Alex, Häsler, Lisa, Hellm, Cortaiga, Gordon, Brian A, Herries, Elizabeth, Hoechst-Swisher, Laura, Hofmann, Anna, Holtzman, David, Hornbeck, Russ, Igor, Yakushev, Ihara, Ryoko, Ikeuchi, Takeshi, Ikonomovic, Snezana, Ishii, Kenji, Benzinger, Tammie L S, Jack, Clifford, Jerome, Gina, Johnson, Erik, Kaeser, Stephan, Kasuga, Kensaku, Keefe, Sarah, Klunk, William Bill, Koeppe, Robert, Koudelis, Deb, Kuder-Buletta, Elke
Publikováno v:
The lancet / Neurology 21(4), 329-341 (2022). doi:10.1016/S1474-4422(22)00027-8
Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression of Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its e
Autor:
Wheelock, Muriah D, Strain, Jeremy F, Fox, Nick C, Graff-Radford, Neill R, Hassenstab, Jason, Jack, Clifford R, Karch, Celeste M, Levin, Johannes, McDade, Eric M, Perrin, Richard J, Schofield, Peter R, Xiong, Chengjie, Mansfield, Patricia, Morris, John C, Bateman, Randal J, Jucker, Mathias, Benzinger, Tammie L S, Ances, Beau M, Eggebrecht, Adam T, Gordon, Brian A, Network, Dominantly Inherited Alzheimer, Tu, Jiaxin Cindy, Tanenbaum, Aaron, Preische, Oliver, Chhatwal, Jasmeer P, Cash, David M, Cruchaga, Carlos, Fagan, Anne M
Publikováno v:
Brain 146(7), 2928-2943 (2023). doi:10.1093/brain/awac498
Neurofilament light chain, a putative measure of neuronal damage, is measurable in blood and CSF and is predictive of cognitive function in individuals with Alzheimer’s disease. There has been limited prior work linking neurofilament light and func
Autor:
Luckett, Patrick H., Chen, Charlie, Jucker, Mathias, Levin, Johannes, Masters, Colin L., Mori, Hiroshi, Noble, James M., Salloway, Stephen, Schofield, Peter R., Brickman, Adam M., Brooks, William S., Cash, David M., Gordon, Brian A., Fulham, Michael J., Ghetti, Bernardino, Jack, Clifford R., Vöglein, Jonathan, Klunk, William E., Koeppe, Robert, Su, Yi, Weiner, Michael, Wang, Qing, Marcus, Daniel, Wisch, Julie, Koudelis, Deborah, Joseph-Mathurin, Nelly, Cash, Lisa, Hornbeck, Russ, Xiong, Chengjie, Perrin, Richard J., Karch, Celeste M., Hassenstab, Jason, McDade, Eric, Morris, John C., Berman, Sarah B., Benzinger, Tammie L. S., Bateman, Randall J., Ances, Beau M., Chhatwal, Jasmeer P., Cruchaga, Carlos, Fagan, Anne M., Farlow, Martin R., Fox, Nick C.
Publikováno v:
Alzheimer's and dementia 19(1), 274-284 (2023). doi:10.1002/alz.12661
INTRODUCTIONAs the number of biomarkers used to study Alzheimer's disease (AD) continues to increase, it is important to understand the utility of any given biomarker, as well as what additional information a biomarker provides when compared to other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade461e26f459486a15028d9902bed28
https://pub.dzne.de/record/163780
https://pub.dzne.de/record/163780
Autor:
Bowles, Kathryn R, Pugh, Derian A, Cherry, Jonathan D, Karch, Celeste M, Frucht, Steven J, Kopell, Brian H, Peter, Inga, Park, Y. J., Consortium, International Parkinson’s Disease Genomics, Charney, Alexander, Raj, Towfique, Crary, John F, Liu, Yiyuan, Goate, A. M., Patel, Tulsi, Renton, Alan E, Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah
Publikováno v:
Molecular neurodegeneration 17(1), 48 (2022). doi:10.1186/s13024-022-00551-x
Parkinson's disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this association have not been identified.To better understand the genetic contribution of this reg
Autor:
Joseph-Mathurin, Nelly, Wang, Guoqiao, Massoumzadeh, Parinaz, Hornbeck, Russ C, Allegri, Ricardo F, Ances, Beau M, Berman, Sarah B, Brickman, Adam M, Brooks, William S, Cash, David M, Chhatwal, Jasmeer P, Chui, Helena C, Kantarci, Kejal, Correia, Stephen, Cruchaga, Carlos, Farlow, Martin R, Fox, Nick C, Fulham, Michael, Ghetti, Bernardino, Graff-Radford, Neill R, Johnson, Keith A, Karch, Celeste M, Laske, Christoph, Jack, Clifford R, Lee, Athene K W, Levin, Johannes, Masters, Colin L, Noble, James M, O'Connor, Antoinette, Perrin, Richard J, Preboske, Gregory M, Ringman, John M, Rowe, Christopher C, Salloway, Stephen, McDade, Eric, Saykin, Andrew J, Schofield, Peter R, Shimada, Hiroyuki, Shoji, Mikio, Suzuki, Kazushi, Villemagne, Victor L, Xiong, Chengjie, Yakushev, Igor, Morris, John C, Bateman, Randall J, Hassenstab, Jason, Benzinger, Tammie L S, Network, Dominantly Inherited Alzheimer, Blazey, Tyler M, Gordon, Brian A, Su, Yi, Chen, Gengsheng
Publikováno v:
Neurology 96(12), e1632-e1645 (2021). doi:10.1212/WNL.0000000000011542
Neurology
article-version (Version of Record) 3
Neurology
article-version (Version of Record) 3
ObjectiveTo investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds and characterize individuals at high risk for developing hemorrhagic amyloid-related imaging abnormality (ARI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edb893204d0bbc0bc95a1a0a2549e28
https://pub.dzne.de/record/155387
https://pub.dzne.de/record/155387
Autor:
Barthélemy, Nicolas R, Li, Yan, Morris, John C, Neimeyer, Katie, Noble, James, Norton, Joanne, Perrin, Richard, Raichle, Marc, Renton, Alan, Ringman, John, Roh, Jee Hoon, Salloway, Stephen, Schofield, Peter, Karch, Celeste M, Shimada, Hiroyuki, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Taddei, Kevin, Wang, Peter, Xiong, Chengjie, Xu, Xiong, Allegri, Ricardo, Mendez, Patricio Chrem, Berman, Sarah B, Ikeuchi, Takeshi, Mori, Hiroshi, Shoji, Mikio, Joseph-Mathurin, Nelly, Farlow, Martin, Chhatwal, Jasmeer, Graff-Radford, Neill R, Schofield, Peter R, Masters, Colin L, Martins, Ralph N, O'Connor, Antoinette, Gordon, Brian A, Fox, Nick C, Levin, Johannes, Jucker, Mathias, Gabelle, Audrey, Lehmann, Sylvain, Sato, Chihiro, Bateman, Randall J, McDade, Eric, Network, Dominantly Inherited Alzheimer, Hassenstab, Jason, Bateman, Randy, Bechara, Jacob, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William Bill, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Benzinger, Tammie L S, Chrem Mendez, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, Donahue, Tamara, Douglas, Jane, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Fitzpatrick, Colleen, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Fagan, Anne M, Goate, Alison, Goldman, Jill, Gordon, Brian, Graff-Radford, Neill, Gray, Julia, Groves, Alexander, Hoechst-Swisher, Laura, Holtzman, David, Hornbeck, Russ, Perrin, Richard J, DiBari, Siri Houeland, Ikonomovic, Snezana, Jerome, Gina, Karch, Celeste, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William Bill, Koeppe, Robert, Kuder-Buletta, Elke, Goate, Alison M, Laske, Christoph, Lee, Jae-Hong, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Maue-Dreyfus, Denise, Morris, John, Nagamatsu, Akem
Publikováno v:
Nat Med
Nature Medicine
Nature Medicine, Nature Publishing Group, 2020, 26 (3), pp.398-407. ⟨10.1038/s41591-020-0781-z⟩
Nature medicine 26(3), 398-407 (2020). doi:10.1038/s41591-020-0781-z
Nature Medicine, 2020, 26 (3), pp.398-407. ⟨10.1038/s41591-020-0781-z⟩
Nature Medicine
Nature Medicine, Nature Publishing Group, 2020, 26 (3), pp.398-407. ⟨10.1038/s41591-020-0781-z⟩
Nature medicine 26(3), 398-407 (2020). doi:10.1038/s41591-020-0781-z
Nature Medicine, 2020, 26 (3), pp.398-407. ⟨10.1038/s41591-020-0781-z⟩
International audience; Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847a501e1bdb3c5f6dd0fb4d5a0c7d7e
https://europepmc.org/articles/PMC7309367/
https://europepmc.org/articles/PMC7309367/
Autor:
Schultz, Stephanie A, Strain, Jeremy F, Berman, Sarah B, Brickman, Adam M, Cash, David M, Chhatwal, Jasmeer, Cruchaga, Carlos, Ewers, Michael, Fox, Nick N, Ghetti, Bernardino, Goate, Alison, Graff-Radford, Neill R, Adedokun, Adedamola, Hassenstab, Jason J, Hornbeck, Russ, Jack, Clifford, Johnson, Keith, Joseph-Mathurin, Nelly, Karch, Celeste M, Koeppe, Robert A, Lee, Athene K W, Levin, Johannes, Masters, Colin, Wang, Qing, McDade, Eric, Perrin, Richard J, Rowe, Christopher C, Salloway, Stephen, Saykin, Andrew J, Sperling, Reisa, Su, Yi, Villemagne, Victor L, Vöglein, Jonathan, Weiner, Michael, Preische, Oliver, Xiong, Chengjie, Fagan, Anne M, Morris, John C, Bateman, Randall J, Benzinger, Tammie L S, Jucker, Mathias, Gordon, Brian A, Network, Dominantly Inherited Alzheimer, Kuhle, Jens, Flores, Shaney, Keefe, Sarah, Dincer, Aylin, Ances, Beau M
Publikováno v:
Neurobiology of Disease
Neurobiology of disease 142, 104960-(2020). doi:10.1016/j.nbd.2020.104960
Neurobiology of Disease, Vol 142, Iss, Pp 104960-(2020)
Neurobiology of disease 142, 104960-(2020). doi:10.1016/j.nbd.2020.104960
Neurobiology of Disease, Vol 142, Iss, Pp 104960-(2020)
Neurofilament light chain (NfL) is a protein that is selectively expressed in neurons. Increased levels of NfL measured in either cerebrospinal fluid or blood is thought to be a biomarker of neuronal damage in neurodegenerative diseases. However, the
Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease
Autor:
Dincer, Aylin, Gordon, Brian A, Allegri, Ricardo, Ances, Beau M, Berman, Sarah B, Brickman, Adam M, Brooks, William S, Cash, David M, Chhatwal, Jasmeer P, Farlow, Martin R, la Fougère, Christian, Fox, Nick C, Hari-Raj, Amrita, Fulham, Michael J, Jack, Clifford R, Joseph-Mathurin, Nelly, Karch, Celeste M, Lee, Athene, Levin, Johannes, Masters, Colin L, McDade, Eric M, Oh, Hwamee, Perrin, Richard J, Keefe, Sarah J, Raji, Cyrus, Salloway, Stephen P, Schofield, Peter R, Su, Yi, Villemagne, Victor L, Wang, Qing, Weiner, Michael W, Xiong, Chengjie, Yakushev, Igor, Morris, John C, Flores, Shaney, Bateman, Randall J, L S Benzinger, Tammie, DIAN, Dominantly Inherited Alzheimer Network, McKay, Nicole S, Paulick, Angela M, Shady Lewis, Kristine E, Feldman, Rebecca L, Hornbeck, Russ C
Publikováno v:
NeuroImage: Clinical 28, 102491-(2020). doi:10.1016/j.nicl.2020.102491
NeuroImage: Clinical, Vol 28, Iss, Pp 102491-(2020)
NeuroImage : Clinical
NeuroImage: Clinical, Vol 28, Iss, Pp 102491-(2020)
NeuroImage : Clinical
Highlights • Cortical signatures selective to AD could provide an early MRI biomarker. • Autosomal dominant Alzheimer disease (ADAD) may model an ideal AD signature. • ADAD and late-onset maps overlap in parietal cortex but contain unique featu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2137b8c6fb5949e67aad2cd45279f38e
https://pub.dzne.de/record/154742
https://pub.dzne.de/record/154742
Autor:
Karch, Celeste M, Kao, Aimee W, Karydas, Anna, Onanuga, Khadijah, Martinez, Rita, Argouarch, Andrea, Wang, Chao, Huang, Cindy, Sohn, Peter Dongmin, Bowles, Kathryn R, Spina, Salvatore, Silva, M Catarina, Marsh, Jacob A, Hsu, Simon, Pugh, Derian A, Ghoshal, Nupur, Norton, Joanne, Huang, Yadong, Lee, Suzee E, Seeley, William W, Theofilas, Panagiotis, Grinberg, Lea T, Moreno, Fermin, McIlroy, Kathryn, Boeve, Bradley F, Cairns, Nigel J, Crary, John F, Haggarty, Stephen J, Ichida, Justin K, Kosik, Kenneth S, Miller, Bruce L, Gan, Li, Goate, Alison M, Temple, Sally, Tau Consortium Stem Cell Group
Publikováno v:
Stem cell reports, vol 13, iss 5
Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::69cec0b5749f331cf52c5ba02705db07
https://escholarship.org/uc/item/3qq1v8t1
https://escholarship.org/uc/item/3qq1v8t1