Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Ivonne M.C.M. Rietjens"'
Autor:
Isaac Omwenga, Hans G.J. Mol, Jochem Louisse, L W Kanja, Ivonne M.C.M. Rietjens, Shensheng Zhao
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 95(4), 1287-1301
Archives of Toxicology 95 (2021) 4
Archives of Toxicology, 95(4), 1287-1301
Archives of Toxicology 95 (2021) 4
Organophosphate pesticides (OPs) are known to inhibit acetylcholine esterase (AChE), a critical effect used to establish health-based guidance values. This study developed a combined in vitro–in silico approach to predict AChE inhibition by the OP
Publikováno v:
Archives of Toxicology, 95(5), 1573-1593
Archives of Toxicology 95 (2021) 5
Archives of Toxicology
Archives of Toxicology 95 (2021) 5
Archives of Toxicology
The present study predicts in vivo human and rat red blood cell (RBC) acetylcholinesterase (AChE) inhibition upon diazinon (DZN) exposure using physiological based kinetic (PBK) modelling-facilitated reverse dosimetry. Due to the fact that both DZN a
Publikováno v:
Toxicology Letters 337 (2021)
Toxicology Letters, 337, 1-6
Toxicology Letters, 337, 1-6
Accumulation of N2-(trans-isoestragol-3′-yl)-2′-deoxyguanosine (E-3′-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficien
Publikováno v:
Toxicology in Vitro 79 (2022)
Toxicology in Vitro, 79
Toxicology in Vitro, 79
Potential consequences of combined exposure to the selected food-borne alkenylbenzenes safrole and estragole or their proximate carcinogenic 1′-hydroxy metabolites were evaluated in vitro and in silico. HepG2 cells were exposed to 1′-hydroxyestra
Publikováno v:
Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry, 70(1), 343-352
Journal of Agricultural and Food Chemistry 70 (2022) 1
Journal of Agricultural and Food Chemistry, 70(1), 343-352
Journal of Agricultural and Food Chemistry 70 (2022) 1
A physiologically based pharmacokinetic (PBPK) model was developed for daidzein and its metabolite S-equol. Anaerobic in vitro incubations of pooled fecal samples from S-equol producers and nonproducers allowed definition of the kinetic constants. PB
Autor:
Kaushik Mitra, Grover P. Miller, James P. Driscoll, Donglu Zhang, Klarissa D. Jackson, Ivonne M.C.M. Rietjens, S. Cyrus Khojasteh
Publikováno v:
Drug Metabolism Reviews, 52(3), 333-365
Drug Metabolism Reviews 52 (2020) 3
Drug Metabolism Reviews 52 (2020) 3
Biotransformation is one of the main mechanisms used by the body to eliminate drugs. As drug molecules become more complicated, the involvement of drug metabolizing enzymes increases beyond those that are typically studied, such as the cytochrome P45
Autor:
Ignacio Miro Estruch, Laura H.J. de Haan, Aziza Hussein Bakheit Adam, Jochem Louisse, Guido J. E. J. Hooiveld, Ivonne M.C.M. Rietjens
Publikováno v:
Cell biology and toxicology, 36, 417-435
Cell Biology and Toxicology
Cell biology and toxicology 36 (2020)
Cell Biology and Toxicology
Cell biology and toxicology 36 (2020)
Diethylstilbestrol (DES) is a synthetic estrogen and proven human teratogen and carcinogen reported to act via the estrogen receptor α (ERα). Since the endogenous ERα ligand 17β-estradiol (E2) does not show these adverse effects to a similar exte
Publikováno v:
Archives of Toxicology, 93(10), 2943-2960
Archives of Toxicology, 93(10), 2943-2960. Berlin [et al.]: Springer
Archives of Toxicology 93 (2019) 10
Archives of Toxicology, 93(10), 2943-2960. Berlin [et al.]: Springer
Archives of Toxicology 93 (2019) 10
The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical sp
Publikováno v:
Food and Chemical Toxicology 130 (2019)
Food and Chemical Toxicology, 130, 142-153
Food and Chemical Toxicology, 130, 142-153
In this study five types of herbal teas were used to quantify the effect of comminution of the leaves on resulting PA exposure. Results show that PA levels extracted from intact leaves were consistently lower than from comminuted tea leaves. The Marg
Autor:
Ivonne M.C.M. Rietjens, Jacques Vervoort, Anna Maslowska-Gornicz, Karsten Beekmann, Nico W. van den Brink
Publikováno v:
Critical Reviews in Toxicology, 48(8), 666-681
Critical Reviews in Toxicology 48 (2018) 8
Critical Reviews in Toxicology 48 (2018) 8
This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological s