Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Huwate Yeerna"'
Autor:
Paul Riviere, Amélie Boichard, Pablo Tamayo, Razelle Kurzrock, Timothy V. Pham, Huwate Yeerna, Aaron M. Goodman
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1680-1694 (2020)
Molecular Oncology
Molecular Oncology
Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death liga
Autor:
Sudeep, Banerjee, Hyunho, Yoon, Stephanie, Ting, Chih-Min, Tang, Mayra, Yebra, Alexander T, Wenzel, Huwate, Yeerna, Jill P, Mesirov, Robert J, Wechsler-Reya, Pablo, Tamayo, Jason K, Sicklick
Publikováno v:
Mol Cancer Ther
Gastrointestinal stromal tumor (GIST) is commonly driven by oncogenic KIT mutations that are effectively targeted by imatinib, a tyrosine kinase inhibitor (TKI). However, IM does not cure GIST and adjuvant therapy only delays recurrence in high-risk
Autor:
Emily Damato, Kim Stegmaier, Christian Berrios, Pablo Tamayo, Ole Gjoerup, James A. DeCaprio, Jong Wook Kim, Michael P. Washburn, Laurence Florens, Amy E. Schade, Amanda Balboni Iniguez, Huwate Yeerna, Guillaume Adelmant, Miju Kim, Nathanael S. Gray, William C. Hahn, Jarrod A. Marto
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutati
Autor:
Anshuman Panda, Huwate Yeerna, Anupama Yadav, Tyler Klecha, Hossein Khiabanian, Markus Lux, Shridar Ganesan, Pablo Tamayo, Gyan Bhanot, Sebastian Doniach, Alexander Schulz, Michael Biehl, Amartya Singh
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 48(13), 7079-7098. Oxford University Press
Nucleic Acids Research, 48(13), 7079-7098. Oxford University Press
We give results from a detailed analysis of human Ribosomal Protein (RP) levels in normal and cancer samples and cell lines from large mRNA, copy number variation and ribosome profiling datasets. After normalizing total RP mRNA levels per sample, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61dab1c299ed9b01b4482a17c6f6161
https://doi.org/10.1093/nar/gkaa485
https://doi.org/10.1093/nar/gkaa485
Autor:
Bradford Siegele, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind, Vachan Vadmal, Moraima Zaida, Zhiyong Wang, Lynn Vitale-Cross, Pablo Tamayo, Huwate Yeerna, Kun-Liang Guan, Alfredo A. Molinolo, Daniel Martin, Sok Ching Cheong, Juan Luis Callejas Valera, Ramiro Iglesias-Bartolome, Scott M. Lippman, Rick F. Thorne, Xiaodong Feng, Toshiro Moroishi, Maria Sol Degese
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular mechanisms are still poorly understood. A pancancer analysis of core Hippo kinases and their candi
Autor:
Dinh Diep, Brian M. Reilly, Tiffany N. Tanaka, Pablo Tamayo, Rafael Bejar, Kun Zhang, Huwate Yeerna
Publikováno v:
Blood advances, vol 3, iss 19
Recurrent mutations implicate several epigenetic regulators in the early molecular pathobiology of myelodysplastic syndromes (MDS). We hypothesized that MDS subtypes defined by DNA methylation (DNAm) patterns could enhance our understanding of MDS di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3602f3d486f3c57fdf60115d7c1a8576
https://escholarship.org/uc/item/19d4b7cd
https://escholarship.org/uc/item/19d4b7cd
Autor:
J. Silvio Gutkind, Nijiro Nohata, Victoria Wu, Huwate Yeerna, Olivier Harismendy, Joshua Chiou, Robert B. Russell, Pablo Tamayo, Francesco Raimondi, Asuka Inoue
Publikováno v:
The Journal of biological chemistry, vol 294, iss 29
G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–associated molecules mediating signal transmission, and their involvement in key physiological functions is well-established. The ability of GPCRs to regulate a vast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae378de1db36e9feb6084bda21b293d8
http://www.jbc.org/content/294/29/11062.full.pdf
http://www.jbc.org/content/294/29/11062.full.pdf
Autor:
Xuefeng Zhang, Huwate Yeerna, Anne N. Murphy, Xingyu Wu, J. Silvio Gutkind, Zhiyong Wang, Scott M. Lippman, Victoria Wu, Panomwat Amornphimoltham, Qianming Chen, Yusuke Goto, Toshinori Ando, Pablo Tamayo
Publikováno v:
Cancer research. 79(17)
Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented t
Autor:
Huwate Yeerna, Bharat A. Panuganti, Pablo Tamayo, Akihiro Sakai, Koji Ebisumoto, Yusuke Goto, Sunny Haft, J. Silvio Gutkind, Takahito Fukusumi, Andrew B. Sharabi, Jacqueline A. Hubbard, Yuki Saito, William Kim, Shuling Ren, Sayed Sadat, Mizuo Ando, Theresa Guo, Joseph A. Califano, Chao Liu
Publikováno v:
Clin Cancer Res
Purpose: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the
Autor:
Katherine Licon, John Paul Shen, Ana Bojorquez-Gomez, Andrew M. Gross, Chu Ping Qiu, Huwate Yeerna, Jia L. Xu, Rohith Srivas, Haico van Attikum, Robert W. Sobol, Vignesh Sivaganesh, Su Ming Sun, Eric J. Jaehnig, Daniel Pekin, Jianfeng Li, Kristin Klepper, Trey Ideker
Publikováno v:
Oncotarget
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we