Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Franziska Theilig"'
Autor:
Markus M. Rinschen, Jennifer L. Harder, Madalina E. Carter-Timofte, Luis Zanon Rodriguez, Carmen Mirabelli, Fatih Demir, Naziia Kurmasheva, Suresh K. Ramakrishnan, Madlen Kunke, Yifan Tan, Anja Billing, Eileen Dahlke, Alexey A. Larionov, Wibke Bechtel-Walz, Ute Aukschun, Marlen Grabbe, Rikke Nielsen, Erik I. Christensen, Matthias Kretzler, Tobias B. Huber, Christiane E. Wobus, David Olagnier, Gary Siuzdak, Florian Grahammer, Franziska Theilig
Publikováno v:
Rinschen, M M, Harder, J L, Carter-Timofte, M E, Zanon Rodriguez, L, Mirabelli, C, Demir, F, Kurmasheva, N, Ramakrishnan, S K, Kunke, M, Tan, Y, Billing, A, Dahlke, E, Larionov, A A, Bechtel-Walz, W, Aukschun, U, Grabbe, M, Nielsen, R, Christensen, E I, Kretzler, M, Huber, T B, Wobus, C E, Olagnier, D, Siuzdak, G, Grahammer, F & Theilig, F 2022, ' VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney ', Science Signaling, vol. 15, no. 762, pp. eabo7940 . https://doi.org/10.1126/scisignal.abo7940
The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls reabsorption of nutrients such as fatty acids, amin
Autor:
Naomi Issler, Sara Afonso, Irith Weissman, Katrin Jordan, Alberto Cebrian-Serrano, Katrin Meindl, Eileen Dahlke, Konstantin Tziridis, Guanhua Yan, José M. Robles-López, Lydia Tabernero, Vaksha Patel, Anne Kesselheim, Enriko D. Klootwijk, Horia C. Stanescu, Simona Dumitriu, Daniela Iancu, Mehmet Tekman, Monika Mozere, Graciana Jaureguiberry, Priya Outtandy, Claire Russell, Anna-Lena Forst, Christina Sterner, Elena-Sofia Heinl, Helga Othmen, Ines Tegtmeier, Markus Reichold, Ina Maria Schiessl, Katharina Limm, Peter Oefner, Ralph Witzgall, Lifei Fu, Franziska Theilig, Achim Schilling, Efrat Shuster Biton, Limor Kalfon, Ayalla Fedida, Elite Arnon-Sheleg, Ofer Ben Izhak, Daniella Magen, Yair Anikster, Holger Schulze, Christine Ziegler, Martin Lowe, Benjamin Davies, Detlef Böckenhauer, Robert Kleta, Tzipora C. Falik Zaccai, Richard Warth
Publikováno v:
J Am Soc Nephrol
Issler, N, Afonso, S, Weissman, I, Jordan, K, Cebrian-Serrano, A, Meindl, K, Dahlke, E, Tziridis, K, Yan, G, Robles-López, J M, Tabernero, L, Patel, V, Kesselheim, A, Klootwijk, E D, Stanescu, H C, Dumitriu, S, Iancu, D, Tekman, M, Mozere, M, Jaureguiberry, G, Outtandy, P, Russell, C, Forst, A-L, Sterner, C, Heinl, E-S, Othmen, H, Tegtmeier, I, Reichold, M, Schiessl, I M, Limm, K, Oefner, P, Witzgall, R, Fu, L, Theilig, F, Schilling, A, Shuster Biton, E, Kalfon, L, Fedida, A, Arnon-Sheleg, E, Ben Izhak, O, Magen, D, Anikster, Y, Schulze, H, Ziegler, C, Lowe, M, Davies, B, Böckenhauer, D, Kleta, R, Falik Zaccai, T C & Warth, R 2022, ' A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 4, pp. 732-745 . https://doi.org/10.1681/ASN.2021101312
Issler, N, Afonso, S, Weissman, I, Jordan, K, Cebrian-Serrano, A, Meindl, K, Dahlke, E, Tziridis, K, Yan, G, Robles-López, J M, Tabernero, L, Patel, V, Kesselheim, A, Klootwijk, E D, Stanescu, H C, Dumitriu, S, Iancu, D, Tekman, M, Mozere, M, Jaureguiberry, G, Outtandy, P, Russell, C, Forst, A-L, Sterner, C, Heinl, E-S, Othmen, H, Tegtmeier, I, Reichold, M, Schiessl, I M, Limm, K, Oefner, P, Witzgall, R, Fu, L, Theilig, F, Schilling, A, Shuster Biton, E, Kalfon, L, Fedida, A, Arnon-Sheleg, E, Ben Izhak, O, Magen, D, Anikster, Y, Schulze, H, Ziegler, C, Lowe, M, Davies, B, Böckenhauer, D, Kleta, R, Falik Zaccai, T C & Warth, R 2022, ' A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 4, pp. 732-745 . https://doi.org/10.1681/ASN.2021101312
BACKGROUND: The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely understoo
Autor:
Makhabbat Saudenova, Jessica Promnitz, Gerrit Ohrenschall, Nina Himmerkus, Martina Böttner, Madlen Kunke, Markus Bleich, Franziska Theilig
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1869:119190
Cathepsin B (CatB) is a very abundant lysosomal protease with endo- and carboxydipeptidase activities and even ligase features. In this review, we will provide a general characterization of CatB and describe structure, structure-derived properties an
Autor:
Theresa Riebeling, Domagoj Schunk, Charlotte Flüh, Rebecca Wilson, Fred Lühder, Bartosz Tyczynski, Laura Ramos Garcia, Philipp M. Doldi, Stefan Krautwald, Friederike Michels, Ulrich Kunzendorf, Kunzah Jamal, Eileen Dahlke, Franziska Theilig, Benedikt Kolbrink, Pascal Meier, Caroline Moerke, Andreas Kribben, Friedrich Alexander von Samson-Himmelstjerna
Publikováno v:
Cell Death & Differentiation
Cell Death and Differentiation
Cell Death and Differentiation
The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of RIPK1-dependent organ damage in str
Autor:
Mustafa Nazıroğlu, Gerburg K. Schwaerzer, László Pecze, Bilal Çiğ, Franziska Theilig, Yener Yazğan
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports
In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing exc
Autor:
Franziska Theilig
Publikováno v:
Annals of Anatomy - Anatomischer Anzeiger. 192:125-132
Chronic kidney disease is characterized by the decline in renal excretory, homeostatic and endocrine functions. In most instances, the primary event is glomerular injury. With ongoing progression and glomerular extracapillary proliferation, tubuloint
Autor:
Franziska Theilig, Qingyu Wu
Publikováno v:
American journal of physiology. Renal physiology
The balance between vasoconstrictor/sodium-retaining and vasodilator/natriuretic systems is essential for maintaining body fluid and electrolyte homeostasis. Natriuretic peptides, such as atrial natriuretic peptide (ANP), belong to the vasodilator/na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709777804d49f3bea4a174a32e217dfa
https://europepmc.org/articles/PMC4436998/
https://europepmc.org/articles/PMC4436998/
Autor:
Hasan Kulaksiz, Franziska Theilig, Sebastian Bachmann, Wolfgang Stremmel, Birgit Kallinowski, Hans-Dieter Riedel, Sven G. Gehrke, Uta Merle, Evelyn Fein
Publikováno v:
Histochemistry and Cell Biology. 127:221-226
The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism. Mutations in the Hjv and TfR2 gene cause hemochromatosis. We investigated the expression and cellular localization of Hjv and TfR2
Autor:
Sebastian Bachmann, Hasan Kulaksiz, Yalcin Cetin, A Janetzko, Daniel Rost, Sven G. Gehrke, Wolfgang Stremmel, Franziska Theilig
Publikováno v:
Journal of Endocrinology. 184:361-370
It is generally accepted that iron homeostasis is mainly controlled in the gastrointestinal tract by absorption of dietary iron. However, recent studies have shown that the kidneys are also involved in iron metabolism. Since the iron-regulatory and a
Autor:
Volker Henn, Friedrich W. Herberg, Michael Beyermann, Eduard Stefan, Walter Rosenthal, Burkhard Wiesner, Giovana Valenti, Sebastian Bachmann, Roland Schmitt, Dorothea Lorenz, Enno Klussmann, Eberhard Krause, Grazia Tamma, Franziska Theilig, Bayram Edemir, Lutz Vossebein
Publikováno v:
Journal of Biological Chemistry. 279:26654-26665
Arginine vasopressin (AVP) increases the water permeability of renal collecting duct principal cells by inducing the fusion of vesicles containing the water channel aquaporin-2 (AQP2) with the plasma membrane (AQP2 shuttle). This event is initiated b