Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Franz J. Zemp"'
Autor:
Andrew J. Mungall, Yussanne Ma, Sorana Morrissy, Bradley St. Croix, Michelle Kushida, Ana Nikolic, Alex Murison, Mathieu Lupien, Douglas J. Mahoney, Fiona J. Coutinho, Peter B. Dirks, Florence M.G. Cavalli, Richard A. Moore, Paul Guilhamon, Michael D. Taylor, Katrina Ellestad, John J.Y. Lee, Michael J. Johnston, Aly Abdelkareem, Steven Seaman, Marco A. Marra, Nicoletta Ninkovic, Marco Gallo, Franz J. Zemp, Trevor J. Pugh
Publikováno v:
Genome Research. 29:1211-1222
SUMMARYWe investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating the highest-resolution 3D genome maps to-date for this cancer. Integration of DNA contact maps with chromat
Autor:
Michael J. Monument, Doha Itani, Jahanara Rajwani, Douglas J. Mahoney, Pinaki Bose, Arvind K. Singla, Frank R. Jirik, Kurt N. Hildebrand, Franz J. Zemp, Kayla L. Marritt, Reid McNeil, Karys M. Hildebrand
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253864 (2021)
PLoS ONE
PLoS ONE
Sarcomas are rare, difficult to treat, mesenchymal lineage tumours that affect children and adults. Immunologically-based therapies have improved outcomes for numerous adult cancers, however, these therapeutic strategies have been minimally effective
Autor:
Runze Yang, Jeff Dunn, John Kelly, Reza Mirzaei, Candice Poon, Pinaki Bose, Susobhan Sarkar, Manoj Kumar Mishra, Khalil S. Rawji, Franz J. Zemp, V. Wee Yong
Publikováno v:
Science translational medicine. 12(537)
Glioblastomas are generally incurable partly because monocytes, macrophages, and microglia in afflicted patients do not function in an antitumor capacity. Medications that reactivate these macrophages/microglia, as well as circulating monocytes that
Publikováno v:
Neuro-Oncology. 17:1095-1105
Malignant gliomas are intracranial tumors that account for 3%–8% of all cancer-related death. Despite several clinical advances, malignant gliomas remain largely untreatable and median survival time for the high-grade glioblastoma does not exceed 1
Autor:
Xueqing Lun, Grant McFadden, Karlyne M. Reilly, Brienne A. McKenzie, Peter A. Forsyth, Franz J. Zemp, V. Wee Yong
Publikováno v:
Cancer Research. 74:7260-7273
Oncolytic virus therapy is being evaluated in clinical trials for human glioma. While it is widely assumed that the immune response of the patient to the virus infection limits the utility of the therapy, investigations into the specific cell type(s)
Autor:
Franz J. Zemp, Jeffery F. Dunn, Nico van Rooijen, Samuel Weiss, Stephen M. Robbins, John Kelly, Claudia Silva, Dave Kinniburgh, Xiuling Wang, Susobhan Sarkar, Gregory Cairncross, Axinia Döring, Mark G. Hamilton, Xueqing Lun, Peter A. Forsyth, Philippe Mercier, V. Wee Yong, Walter Hader
Publikováno v:
Annals of Neurosciences
Nature Neuroscience, 17, 46-55. Nature Publishing Group
Sarkar, S, Doring, A, Zemp, F J, Silva, C, Lun, X, Wang, X, Kelly, J, Hader, W, Hamilton, M, Mercier, P, Dunn, J F, Kinniburgh, D, van Rooijen, N, Robbins, S, Forsyth, P, Cairncross, G, Weiss, S & Yong, V W 2014, ' Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells ', Nature Neuroscience, vol. 17, pp. 46-55 . https://doi.org/10.1038/nn.3597
Nature Neuroscience, 17, 46-55. Nature Publishing Group
Sarkar, S, Doring, A, Zemp, F J, Silva, C, Lun, X, Wang, X, Kelly, J, Hader, W, Hamilton, M, Mercier, P, Dunn, J F, Kinniburgh, D, van Rooijen, N, Robbins, S, Forsyth, P, Cairncross, G, Weiss, S & Yong, V W 2014, ' Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells ', Nature Neuroscience, vol. 17, pp. 46-55 . https://doi.org/10.1038/nn.3597
Brain tumor initiating cells (BTICs) contribute to the genesis and recurrence of gliomas. We examined whether the microglia and macrophages that are abundant in gliomas alter BTIC growth. We found that microglia derived from non-glioma human subjects
Autor:
John Kelly, Franz J. Zemp, Donna L. Senger, J. Gregory Cairncross, Beichen Sun, Mohamed R. Mohamed, Brian Rabinovich, John C. Bell, Brienne A. McKenzie, Sherin Smallwood, Peter A. Forsyth, Mark G. Hamilton, Samuel Weiss, Lori Maxwell, Masmudur M. Rahman, Xueqing Lun, Hongyuan Zhou, Grant McFadden, Artee Luchman, Owen Stechishin
Publikováno v:
Neuro-Oncology. 15:904-920
Background. Intratumoral heterogeneity in glioblastoma multiforme (GBM) poses a significant barrier to therapy in certain subpopulation such as the tumorinitiating cell population, being shown to be refractory to conventional therapies. Oncolytic vir
Autor:
Stephen M. Robbins, Reza Mirzaei, Susobhan Sarkar, Franz J. Zemp, V. Wee Yong, Wu Wei, Donna L. Senger
Publikováno v:
Cancer research. 77(12)
Oncogenic signaling by NOTCH is elevated in brain tumor-initiating cells (BTIC) in malignant glioma, but the mechanism of its activation is unknown. Here we provide evidence that tenascin-C (TNC), an extracellular matrix protein prominent in malignan
Autor:
Pankaj Tailor, Keith C.K. Lau, Franz J. Zemp, Dae-Sun Kim, Andrea Rakic, Robin M. Yates, Chris Gafuik, Victor Naumenko, Chunfen Zhang, Saif Sikdar, Dale R. Balce, Matthias Ernst, Craig N. Jenne, Douglas J. Mahoney, Ben W. Ewanchuk, Himika Dastidar, Jahanara Rajwani
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications
Nature Communications
Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic compound and oncolytic virus therapies also modulate host immune responses in ways we hypothe
Oncolytic viruses as experimental treatments for malignant gliomas: Using a scourge to treat a devil
Publikováno v:
Cytokine & Growth Factor Reviews. 21:103-117
The concept of oncolytic viral therapy has a century-old history, but only within the last 20 years have oncolytic viruses been considered for the treatment of brain cancers. Viruses such as herpes, measles, and vaccinia have all been known to cause