Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ebbe Boedtkjer"'
Autor:
Mikkel B. Henningsen, Kezia McWhan, Vibeke S. Dam, Marco Mele, Katrine R. Hauerslev, Ninna C. S. Voss, Parag D. Dabir, Eva Balling, Helene L. Pedersen, Pernille Vahl, Tonje Johansen, Trine Tramm, Peer M. Christiansen, Ebbe Boedtkjer
Publikováno v:
Henningsen, M B, McWhan, K, Dam, V S, Mele, M, Hauerslev, K R, Voss, N C S, Dabir, P D, Balling, E, Pedersen, H L, Vahl, P, Johansen, T, Tramm, T, Christiansen, P M & Boedtkjer, E 2022, ' Amplified Ca 2+ dynamics and accelerated cell proliferation in breast cancer tissue during purinergic stimulation ', International Journal of Cancer, vol. 151, no. 7, pp. 1150-1165 . https://doi.org/10.1002/ijc.34147
Intracellular Ca 2+ dynamics shape malignant behaviors of cancer cells. Whereas previous studies focused on cultured cancer cells, we here used breast organoids and colonic crypts freshly isolated from human and murine surgical biopsies. We performed
Autor:
Mikkel B, Henningsen, Kezia, McWhan, Vibeke S, Dam, Marco, Mele, Katrine R, Hauerslev, Ninna C S, Voss, Parag D, Dabir, Eva, Balling, Helene L, Pedersen, Pernille, Vahl, Tonje, Johansen, Trine, Tramm, Peer M, Christiansen, Ebbe, Boedtkjer
Publikováno v:
International journal of cancer. 151(7)
Intracellular Ca
Autor:
Rasmus A, Sloth, Trine V, Axelsen, Maria Sofia, Espejo, Nicolai J, Toft, Ninna C S, Voss, Mark, Burton, Mads, Thomassen, Pernille, Vahl, Ebbe, Boedtkjer
Publikováno v:
British journal of cancer. 127(7)
While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid-base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear.We explore data from h
Autor:
Ebbe, Boedtkjer
Publikováno v:
Reviews of physiology, biochemistry and pharmacology. 182
Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion compositio
Autor:
Ebbe Boedtkjer, Stine F. Pedersen
Publikováno v:
Boedtkjer, E & Pedersen, S F 2020, ' The Acidic Tumor Microenvironment as a Driver of Cancer ', Annual Review of Physiology, vol. 82, pp. 103-126 . https://doi.org/10.1146/annurev-physiol-021119-034627
Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH influence can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbcc79e98e38b2800cef91009fc05fa
https://pure.au.dk/portal/da/publications/the-acidic-tumor-microenvironment-as-a-driver-of-cancer(b1ac3f58-7869-4652-b310-82300c0303f4).html
https://pure.au.dk/portal/da/publications/the-acidic-tumor-microenvironment-as-a-driver-of-cancer(b1ac3f58-7869-4652-b310-82300c0303f4).html
Autor:
Jun Ming Li, Lauren A. Jeffers, Soojung Lee, Yejin Kim, Carlos Gonzalez-Islas, Sadie E. Nennig, Jaegwon Chung, Jae-Kyung Lee, Zhe Jin, Jianjun Chang, Ebbe Boedtkjer, Inyeong Choi, Hannah D. Fulenwider, Christian Aalkjaer, Jesse R. Schank
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Schank, J R, Lee, S, Gonzalez-Islas, C E, Nennig, S E, Fulenwider, H D, Chang, J, Li, J M, Kim, Y, Jeffers, L A, Chung, J, Lee, J-K, Jin, Z, Aalkjær, C, Boedtkjer, E & Choi, I 2020, ' Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1 ', Scientific Reports, vol. 10, no. 1, 11017 . https://doi.org/10.1038/s41598-020-67291-0
Scientific Reports
Schank, J R, Lee, S, Gonzalez-Islas, C E, Nennig, S E, Fulenwider, H D, Chang, J, Li, J M, Kim, Y, Jeffers, L A, Chung, J, Lee, J-K, Jin, Z, Aalkjær, C, Boedtkjer, E & Choi, I 2020, ' Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1 ', Scientific Reports, vol. 10, no. 1, 11017 . https://doi.org/10.1038/s41598-020-67291-0
Scientific Reports
The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding the Na/HCO3 transporter NBCn1 suggest that this pH-regulating protein may affect alcohol-related behavior and response. Here, we examined alcohol consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca542b242805b68dde33f0e0fe904f2
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419699
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419699
Autor:
Anne Sofie Froelunde, Ebbe Boedtkjer, Sukhan Kim, Kristoffer B Hansen, Nicolai Jessen, Marit Edna Ohlenbusch
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)
Breast Cancer Research : BCR
Frølunde, A S, Ohlenbusch, M E, Berg-Hansen, K, Jessen, N, Kim, S & Boedtkjer, E 2018, ' Murine breast cancer feed arteries are thin-walled with reduced α 1A-adrenoceptor expression and attenuated sympathetic vasocontraction ', Breast Cancer Research, vol. 20, 20 . https://doi.org/10.1186/s13058-018-0952-8
Breast Cancer Research : BCR
Frølunde, A S, Ohlenbusch, M E, Berg-Hansen, K, Jessen, N, Kim, S & Boedtkjer, E 2018, ' Murine breast cancer feed arteries are thin-walled with reduced α 1A-adrenoceptor expression and attenuated sympathetic vasocontraction ', Breast Cancer Research, vol. 20, 20 . https://doi.org/10.1186/s13058-018-0952-8
Background Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possible therapeutic targets in matur
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Møller, A L, Hjortdal, V E, Bødtkjer, D B & Boedtkjer, E 2019, ' Acidosis inhibits rhythmic contractions of human thoracic ducts ', Physiological Reports, vol. 7, no. 8, e14074 . https://doi.org/10.14814/phy2.14074
Physiological Reports
Møller, A L, Hjortdal, V E, Bødtkjer, D B & Boedtkjer, E 2019, ' Acidosis inhibits rhythmic contractions of human thoracic ducts ', Physiological Reports, vol. 7, no. 8, e14074 . https://doi.org/10.14814/phy2.14074
Physiological Reports
Lymph vessels counteract edema by transporting interstitial fluid from peripheral tissues to the large veins and serve as conduits for immune cells, cancer cells, and pathogens. Because edema during inflammation and malignancies is frequently associa
Autor:
Ebbe, Boedtkjer
Publikováno v:
Cancer metastasis reviews. 38(1-2)
Cell metabolism increases during carcinogenesis. Yet, intracellular pH in solid cancer tissue is typically maintained equal to or above that of normal tissue. This is achieved through accelerated cellular acid extrusion that compensates for the enhan
Publikováno v:
Voss, N C S, Kold-Petersen, H H & Boedtkjer, E 2019, ' Enhanced nitric oxide signaling amplifies vasorelaxation of human colon cancer feed arteries ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 316, no. 1, pp. H245-H254 . https://doi.org/10.1152/ajpheart.00368.2018
Inadequate perfusion of solid cancer tissue results in low local nutrient and oxygen levels and accumulation of acidic waste products. Previous investigations have focused primarily on tumor blood vessel architecture, and we lack information concerni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665622b514fc6642a40631c6b60c6f8
https://pure.au.dk/portal/da/publications/enhanced-nitric-oxide-signaling-amplifies-vasorelaxation-of-human-colon-cancer-feed-arteries(fce94c12-b044-4f3a-8a43-2c60600d6199).html
https://pure.au.dk/portal/da/publications/enhanced-nitric-oxide-signaling-amplifies-vasorelaxation-of-human-colon-cancer-feed-arteries(fce94c12-b044-4f3a-8a43-2c60600d6199).html