Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donal T, Skelly"'
Autor:
Adriana, Tomic, Donal T, Skelly, Ane, Ogbe, Daniel, O'Connor, Matthew, Pace, Emily, Adland, Frances, Alexander, Mohammad, Ali, Kirk, Allott, M, Azim Ansari, Sandra, Belij-Rammerstorfer, Sagida, Bibi, Luke, Blackwell, Anthony, Brown, Helen, Brown, Breeze, Cavell, Elizabeth A, Clutterbuck, Thushan, de Silva, David, Eyre, Sheila, Lumley, Amy, Flaxman, James, Grist, Carl-Philipp, Hackstein, Rachel, Halkerston, Adam C, Harding, Jennifer, Hill, Tim, James, Cecilia, Jay, Síle A, Johnson, Barbara, Kronsteiner, Yolanda, Lie, Aline, Linder, Stephanie, Longet, Spyridoula, Marinou, Philippa C, Matthews, Jack, Mellors, Christos, Petropoulos, Patpong, Rongkard, Cynthia, Sedik, Laura, Silva-Reyes, Holly, Smith, Lisa, Stockdale, Stephen, Taylor, Stephen, Thomas, Timothy, Tipoe, Lance, Turtle, Vinicius Adriano, Vieira, Terri, Wrin, Andrew J, Pollard, Teresa, Lambe, Chris P, Conlon, Katie, Jeffery, Simon, Travis, Philip, Goulder, John, Frater, Alex J, Mentzer, Lizzie, Stafford, Miles W, Carroll, William S, James, Paul, Klenerman, Eleanor, Barnes, Christina, Dold, Nick P, Talbot
The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a518d244a5e69ff766a8ae411fcd798
https://ora.ox.ac.uk/objects/uuid:229c3c98-fcb6-4e98-a612-e9b8d2b02391
https://ora.ox.ac.uk/objects/uuid:229c3c98-fcb6-4e98-a612-e9b8d2b02391
Autor:
Panagiota Zacharopoulou, David A. Duncan, Susanna Dunachie, Nicholas T.Y. Lim, Robert S. Paton, Craig Thompson, Ian D. Pavord, Derek C. Macallan, W J Hurt, Wentao Chen, Donal T. Skelly, P Goulder, Graham S. Ogg, Jian Luo, Wyncoll Dla., Nicholas M. Provine, Luzheng Xue, Chen Y-L., Philip Hopkins, Ali Amini, E Barnes, Matthew Edmans, Jonathan Ball, Jonathan Youngs, Anna L McNaughton, Paul Klenerman, Hannah Sharpe, Teresa Lambe, Vincent N. Miao, Oliver Sampson, Alex K. Shalek, Tihana Bicanic, Susannah Leaver
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009804 (2021)
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
et al. 2021, ' Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients ', PLoS Pathogens, vol. 17, no. 9, e1009804 . https://doi.org/10.1371/journal.ppat.1009804
PLoS Pathogens
Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1affc75f71fbb1aaddb6a4c83a3de
https://doi.org/10.1371/journal.ppat.1009804
https://doi.org/10.1371/journal.ppat.1009804
Autor:
Rebecca P. Payne, Stephanie Longet, James A. Austin, Donal T. Skelly, Wanwisa Dejnirattisai, Sandra Adele, Naomi Meardon, Sian Faustini, Saly Al-Taei, Shona C. Moore, Tom Tipton, Luisa M. Hering, Adrienn Angyal, Rebecca Brown, Alexander R. Nicols, Natalie Gillson, Susan L. Dobson, Ali Amini, Piyada Supasa, Andrew Cross, Alice Bridges-Webb, Laura Silva Reyes, Aline Linder, Gurjinder Sandhar, Jonathan A. Kilby, Jessica K. Tyerman, Thomas Altmann, Hailey Hornsby, Rachel Whitham, Eloise Phillips, Tom Malone, Alexander Hargreaves, Adrian Shields, Ayoub Saei, Sarah Foulkes, Lizzie Stafford, Sile Johnson, Daniel G. Wootton, Christopher P. Conlon, Katie Jeffery, Philippa C. Matthews, John Frater, Alexandra S. Deeks, Andrew J. Pollard, Anthony Brown, Sarah L. Rowland-Jones, Juthathip Mongkolsapaya, Eleanor Barnes, Susan Hopkins, Victoria Hall, Christina Dold, Christopher J.A. Duncan, Alex Richter, Miles Carroll, Gavin Screaton, Thushan I. de Silva, Lance Turtle, Paul Klenerman, Susanna Dunachie, Hibatullah Abuelgasim, Emily Adland, Syed Adlou, Hossain Delowar Akther, Ahmed Alhussni, Mohammad Ali, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Martin Bayley, Helen Brown, Jeremy Chalk, Meera Chand, Anu Chawla, Senthil Chinnakannan, Joseph Cutteridge, Catherine de Lara, Lucy Denly, Ben Diffey, Stavros Dimitriadis, Thomas M. Drake, Timothy Donnison, Maeva Dupont, David Eyre, Alex Fairman, Siobhan Gardiner, Javier Gilbert-Jarmillo, Philip Goulder, Carl-Philipp Hackstein, Sophie Hambleton, Muzlifah Haniffa, Jenny Haworth, Jennifer Holmes, Emily Horner, Anni Jämsén, Chris Jones, Mwila Kasanyinga, Sinead Kelly, Rosemary Kirk, Michael L. Knight, Allan Lawrie, Lian Lee, Lauren Lett, Katy Lillie, Nicholas Lim, Hema Mehta, Alexander J. Mentzer, Denise O’Donnell, Ane Ogbe, Matthew Pace, Brendan A.I. Payne, Gareth Platt, Sonia Poolan, Nicholas Provine, Narayan Ramamurthy, Nichola Robinson, Leigh Romaniuk, Patpong Rongkard, Oliver L. Sampson, Beatrice Simmons, Jarmila S. Spegarova, Emily Stephenson, Kris Subramaniam, James Thaventhiran, Sarah Thomas, Simon Travis, Stephanie Tucker, Helena Turton, Adam Watson, Lisa Watson, Esme Weeks, Robert Wilson, Steven Wood, Rachel Wright, Huiyuan Xiao, Amira A.T. Zawia
Publikováno v:
CELL
Cell
Cell
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the UK to accelerate population coverage with a single dose. At this time, trial data was lacking, and we addressed this in a study of UK healthcare worke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3759990625e1d7316179914d2a3269e4
https://doi.org/10.1016/j.cell.2021.10.011
https://doi.org/10.1016/j.cell.2021.10.011
Autor:
Thomas G Ritter, Juthathip Mongkolsapaya, Beibei Wang, Alexander J. Mentzer, Daniel K. Clare, Neil G. Paterson, Donal T. Skelly, Elizabeth E. Fry, Andy G. Howe, Nigel Temperton, Jingshan Ren, Piyada Supasa, Helen M. Ginn, Helen M. E. Duyvesteyn, S A Johnson, David I. Stuart, Tariq Malik, Wanwisa Dejnirattisai, Aekkachai Tuekprakhon, D. Zhou, Michael S. Diamond, Gavin R. Screaton, David R. Hall, Philip J. R. Goulder, Rita E. Chen, R Nutalai, Chris Jb Mason, Mark A. Williams, James Brett Case, Yuguang Zhao, Chang Liu
Publikováno v:
Cell Host & Microbe
Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1 and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the antigenic structure of S, causing escape from natural or vaccine-induced immunity. Beta is part
Autor:
Beibei Wang, D. Zhou, Elizabeth E. Fry, Julian C. Knight, Amy Flaxman, Valdinete Alves do Nascimento, Alexander J. Mentzer, E Barnes, Alex Pauvolid-Corrêa, Sarah C. Gilbert, M Bittaye, Mark A. Williams, Hulswit Rjg., Gavin R. Screaton, Sandra Belij-Rammerstorfer, Chang Liu, Andrew J. Pollard, David R. Hall, Tao Dong, David I. Stuart, Christina Dold, Felipe Gomes Naveca, Wanwisa Dejnirattisai, Elizabeth A. Clutterbuck, Paul Klenerman, Neil G. Paterson, Helen M. Ginn, C Fernandes da Costa, R Levin, Jingshan Ren, Duyvesteyn Hme., Thomas S. Walter, Aekkachai Tuekprakhon, Miles W. Carroll, Donal T. Skelly, R Nutalai, Yuguang Zhao, Thomas A. Bowden, D W Crook, S A Costa Clemens, Marilda M. Siqueira, P Supasa, Susanna Dunachie, S Bibi, Teresa Lambe, Paola Cristina Resende, Cesar Lopez-Camacho, J Slon-Campos, Juthathip Mongkolsapaya, Fabrícia F. Nascimento
Publikováno v:
Cell
Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. However, new strains have emerged with multiple mutations: P.1 from Brazil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ac3bb39f884cef9702bb4016069aa5
https://doi.org/10.1016/j.cell.2021.03.055
https://doi.org/10.1016/j.cell.2021.03.055
Autor:
Christina Dold, Miles W. Carroll, C Mason, David Hall, Eleanor Barnes, Cesar Lopez-Camacho, F. Gomes Naveca, Jingshan Ren, M C Nunes, D. Zhou, David I. Stuart, P Goulder, Elizabeth E. Fry, Neil G. Paterson, Shabir A. Madhi, Juthathip Mongkolsapaya, Amy Flaxman, S A Johnson, Teresa Lambe, Valdinete Alves do Nascimento, Sandra Belij-Rammerstorfer, Alexander J. Mentzer, Helen M. Ginn, Tao Dong, Thomas S. Walter, Donal T. Skelly, Paul Klenerman, Z Ditse, Marilda M. Siqueira, Sarah C. Gilbert, Susanna Dunachie, James C. Knight, Alex Pauvolid-Corrêa, P Supasa, Mark A. Williams, Vicky L. Baillie, N Serafin, C Fernandes da Costa, Yuguang Zhao, Andrew J. Pollard, R Nutalai, S Bibi, T G Ritter, Fabrícia F. Nascimento, M Bittaye, Wanwisa Dejnirattisai, Beibei Wang, Chang Liu, Gavin R. Screaton, Elizabeth A. Clutterbuck, Aekkachai Tuekprakhon, Paola Cristina Resende, J Slon-Campos, S A Costa Clemens, Nigel J. Temperton, Duyvesteyn Hme., D W Crook, K Da Silva, T Malik
Publikováno v:
Cell
SARS-CoV-2 has undergone progressive change with variants conferring advantage rapidly becoming dominant lineages e.g. B.1.617. With apparent increased transmissibility variant B.1.617.2 has contributed to the current wave of infection ravaging the I
Publikováno v:
Viruses
Volume 13
Issue 5
Viruses, Vol 13, Iss 747, p 747 (2021)
Volume 13
Issue 5
Viruses, Vol 13, Iss 747, p 747 (2021)
As of April 2021, the COVID-19 pandemic has swept through 213 countries and infected more than 132 million individuals globally, posing an unprecedented threat to human health. There are currently no specific antiviral treatments for COVID-19 and vac
Autor:
Derrick W. Crook, Eleanor Barnes, Naomi Coombes, D. Zhou, Jingshan Ren, Duyvesteyn Hme., Bassam Hallis, Alexander J. Mentzer, Christina Dold, Sheila F Lumley, Cesar Lopez-Camacho, Aekkachai Tuekprakhon, Elizabeth E. Fry, Guido C. Paesen, Thomas S. Walter, Donal T. Skelly, Beibei Wang, Helen M. Ginn, David I. Stuart, Chang Liu, Sandra Belij-Rammerstorfer, Julian C. Knight, Susanna Dunachie, Juthathip Mongkolsapaya, S Bibi, Teresa Lambe, Amy Flaxman, Sarah C. Gilbert, P Supasa, Wanwisa Dejnirattisai, Paul Klenerman, M Bittaye, Miles W. Carroll, Tao Dong, Sue Charlton, R Levin, R Nutalai, Yuguang Zhao, William James, Gavin R. Screaton, Kevin R. Bewley, Elizabeth A. Clutterbuck, J Slon-Campos, Andrew J. Pollard
Publikováno v:
Cell
The race to produce vaccines against SARS-CoV-2 began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK–B.1.1.7, South Africa
Autor:
Aekkachai Tuekprakhon, Amy Flaxman, Sarah C. Gilbert, Mark A. Williams, Teresa Lambe, Guido C. Paesen, J Slon-Campos, Eleanor Barnes, William James, N Gent, Naomi Coombes, I Shaik, Sue Charlton, Andrew J. Pollard, Christina Dold, Sheila F Lumley, A Sienkiewicz, Bassam Hallis, Alexander J. Mentzer, D. Zhou, Elizabeth E. Fry, R Nutalai, Kerry J Godwin, Gavin R. Screaton, Cesar Lopez-Camacho, Kevin R. Bewley, Paul Klenerman, Elizabeth A. Clutterbuck, Miles W. Carroll, Wanwisa Dejnirattisai, S Bibi, Beibei Wang, Juthathip Mongkolsapaya, Susanna Dunachie, Sandra Belij-Rammerstorfer, Jingshan Ren, David R. Hall, R Levin, Thomas S. Walter, Donal T. Skelly, Natalie Baker, Helen M. Ginn, P Supasa, Tao Dong, Chang Liu, Neil G. Paterson, Yuguang Zhao, Julian C. Knight, Holly E. Humphries, M Bittaye, David I. Stuart, D W Crook, Duyvesteyn Hme.
Publikováno v:
Cell
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SARS-CoV-2 has caused over 2M deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant
Autor:
Carol L. Murray, Malathy Arumugam, Donal T. Skelly, Lorna Hayden, Edel Hennessy, Lucy Ryan, Daire Healy, Abigail Wilkinson, Éadaoin W. Griffin, Kevin J. Mitchell, Niamh McGarry, Colm Cunningham, Sean M. Garvey, Lucas Silva Tortorelli
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders including schizophrenia, autism, Parkin