Zobrazeno 1 - 10
of 195
pro vyhledávání: '"David E. Housman"'
Autor:
Jiang Chen, Anna M. Westermark, Lewis C. Cantley, Rakesh K. Jain, Brendan Prideaux, John M. Asara, Clary B. Clish, David P. Kodack, Neal I. Lindeman, Christopher W. Ng, Gino B. Ferraro, Ivy X. Chen, Costas A. Lyssiotis, Keene L. Abbott, Ahmed Ali, Jens Nielsen, Zohreh Amoozgar, Dai Fukumura, Raphael Ferreira, Dan G. Duda, Mark Duquette, David E. Housman, Jessica M. Possada, Véronique Dartois, Kamila Naxerova, Shawn M. Davidson, Xin Jin, Matthew G. Vander Heiden, Sylvie Roberge, Todd R. Golub, Amy Deik, Christopher R. Chin, Divya Bezwada, Elena F. Brachtel, Alba Luengo, Landry Blanc
Publikováno v:
Nature Cancer. 2:414-428
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy resistance. Nutrient availability c
Autor:
John W. Day, Sam Sedehizadeh, Thomas A. Cooper, Charles A. Thornton, Christopher B. Burge, Daniel J. Treacy, Thomas T. Wang, David E. Housman, Katy Eichinger, Amanda J. Ward, J. Andrew Berglund, Adam J. Struck, Kirti Bhatt, Joseph Estabrook, Eric T. Wang, David Brook, Hailey Olafson, Tony Westbrook
Publikováno v:
Human Molecular Genetics. 28:1312-1321
Myotonic dystrophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsatellite repeats. Characterized by symptoms in muscle, heart and central nervous system, among others, it is one of the most variable disea
Publikováno v:
Proc Natl Acad Sci U S A
Epstein–Barr virus (EBV) is a ubiquitous human γ-herpesvirus that establishes life-long infection and increases the risk for the development of several cancers and autoimmune diseases. The mechanisms by which chronic EBV infection leads to subsequ
Autor:
Franco Puleo, Anna Y. Aksenova, Claire Moore, Julia A. Hisey, David E. Housman, Sergei M. Mirkin, Erika L. Pearson, Ryan J. McGinty, Eric T. Wang, Alexander A. Shishkin
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2490-2500 (2017)
Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich’s ataxia. While the length of an expandable repeat is the main factor determining disease inheritance, rece
Autor:
David E. Housman, Prasanth Sivakumar, Martina Hallegger, Cristian Bodo, Bernadett Kalmar, Warren Emmett, Hugo Alexandre Mendes Oliveira, Philip Stanier, Adrian M. Isaacs, Alexander E. Conicella, Linda Greensmith, Lydia Teboul, Pietro Fratta, Alessandro Marrero-Gagliardi, Vincent Plagnol, Nicolas L. Fawzi, José M. Brito-Armas, Nicol Birsa, Yichao Yu, Erwin Pauws, Emma Peskett, Joffrey Mianné, Agnieszka M. Ule, Gemma F. Codner, T. Ricketts, Andrea Calvo, Silvia Corrochano, Toby Collins, Jack Humphrey, M Groves, Mark F. Lythgoe, Emanuele Buratti, Francisco E. Baralle, Eric T. Wang, Adriano Chiò, Alan Mejia Maza, Michelle Stewart, Yoichi Gondo, Ryutaro Fukumura, Kitty Lo, Elizabeth M. C. Fisher, Abraham Acevedo-Arozena
Publikováno v:
The EMBO Journal
EMBRO Press
EMBRO Press
TDP-43 (encoded by the gene TARDBP) is an RNA binding protein central to the pathogenesis of amyotrophic lateral sclerosis (ALS). However, how TARDBP mutations trigger pathogenesis remains unknown. Here, we use novel mouse mutants carrying point muta
Publikováno v:
Elsevier
We present the case of an HIV-negative patient clinically diagnosed with relapsing-remitting MS who achieved significant disease improvement on Combivir (zidovudine/lamivudine). Within months of treatment, the patient reported complete resolution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3bbe72f1d04866ef0e04000096fc09
https://europepmc.org/articles/PMC6100748/
https://europepmc.org/articles/PMC6100748/
Autor:
Andreas, Neueder, Theresa A, Gipson, Sophie, Batterton, Hayley J, Lazell, Pamela P, Farshim, Paolo, Paganetti, David E, Housman, Gillian P, Bates
Publikováno v:
Scientific Reports
The heat shock response (HSR) is a mechanism to cope with proteotoxic stress by inducing the expression of molecular chaperones and other heat shock response genes. The HSR is evolutionarily well conserved and has been widely studied in bacteria, cel
Publikováno v:
Nursing research. 66(2)
Background: Advances in DNA sequencing technology have resulted in an abundance of personalized data with challenging clinical utility and meaning for clinicians. This wealth of data has potential to dramatically impact the quality of healthcare. Nur
Autor:
David E. Housman, Sacha B. Nelson, Ann M. Graybiel, Paul W. Tillberg, Charles R. Gerfen, Michael H. Riad, Yasuyuki Shima, Jeffrey Curry, Edward S. Boyden, Jill R. Crittenden
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(40)
The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-cont
Autor:
Matthew Schwede, R. Sean Hill, Anna Rajab, Ramzi Nasir, Muna Al-Saffar, Eric M. Morrow, Michael Schmidt, Sofia B. Lizarraga, Shailender Nagpal, Anh Thu N. Lam, Shawn M. Davidson, Sasmita Mishra, Mirrat Gul Butt, Haroon Rashid Chaudhry, Malak Ei-Quessny, Afzal Javed, Ralph J. DeBerardinis, Syed Imran Murtaza, Tojo Nakayama, Seung Yun Yoo, Ozan Baytas, Ganeshwaran H. Mochida, Chendong Yang, David E. Housman, A. James Barkovich, Jennifer N. Partlow, Saima Niaz, Dylan J. Vaughan, Qing Ouyang
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Mutations that cause neurological phenotypes are highly informative with regard to mechanisms governing human brain function and disease. We report autosomal recessive mutations in the enzyme glutamate pyruvate transaminase 2 (GPT2) in large kindreds