Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Daisuke Ogasawara"'
Autor:
Takashi Kohno, Mamoru Kato, Shinji Kohsaka, Tomohisa Sudo, Ikuo Tamai, Yuichi Shiraishi, Yusuke Okuma, Daisuke Ogasawara, Tatsuya Suzuki, Teruhiko Yoshida, Hiroyuki Mano
Publikováno v:
Cancer Discovery. 12:2509-2515
Summary: Since June 2019, under the umbrella of the national health insurance system, Japan has started cancer genomic medicine (CGM) with comprehensive genomic profiling (CGP) tests. The Ministry of Health, Labour and Welfare (MHLW) of Japan constru
Autor:
Matthew N, Bainbridge, Aloran, Mazumder, Daisuke, Ogasawara, Rami, Abou Jamra, Geneviève, Bernard, Enrico, Bertini, Lydie, Burglen, Heidi, Cope, Ali, Crawford, Alexa, Derksen, Leon, Dure, Emily, Gantz, Margarete, Koch-Hogrebe, Anna C E, Hurst, Sonal, Mahida, Paige, Marshall, Alessia, Micalizzi, Antonio, Novelli, Hongfan, Peng, Diana, Rodriguez, Shira L, Robbins, S Lane, Rutledge, Roberta, Scalise, Sophia, Schließke, Vandana, Shashi, Siddharth, Srivastava, Isabella, Thiffault, Sarah, Topol, Leila, Qebibo, Dagmar, Wieczorek, Benjamin, Cravatt, Svasti, Haricharan, Ali, Torkamani, Rachel, Mahoney
Publikováno v:
Brain : a journal of neurology. 145(10)
The endocannabinoid system is a highly conserved and ubiquitous signalling pathway with broad-ranging effects. Despite critical pathway functions, gene variants have not previously been conclusively linked to human disease. We identified nine childre
Autor:
Dale L. Boger, Daisuke Ogasawara, Julia M. Bittencourt, Enrique Saez, Shreyosree Chatterjee, C. Godio, Ara Sukiasyan, Andrea Galmozzi, Jerome Eberhardt, Benjamin F. Cravatt, Michael D. Cameron, Stefano Forli, Woojoo Kim, Tyler Johns, Dennis W. Wolan, Seiya Kitamura, Bernard P. Kok, Sean M. Kim, Janice H Xu, Srijana Ghimire
Publikováno v:
Nature chemical biology
Activity-based protein profiling (ABPP) has been used extensively to discover and optimize selective inhibitors of enzymes. Here, we show that ABPP can also be implemented to identify the converse – small-molecule enzyme activators. Using a kinetic
Autor:
Daisuke Ogasawara
Publikováno v:
YAKUGAKU ZASSHI. 140:25-29
Despite a continuous increase in R&D spending on potential new medicines, the success rate of drug development has not improved. The pharmaceutical industry is now facing a major challenge. As a college student who was studying pharmaceutical science
Autor:
Benjamin F. Cravatt, Jonathan J. Hulce, Daisuke Ogasawara, Taka-Aki Ichu, Alex Reed, Olesya A. Ulanovskaya, Hui Jing
Publikováno v:
Journal of Medicinal Chemistry. 62:1643-1656
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lyso-phosphatidylserine (lyso-PS) and lyso-phosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/P
Autor:
Christopher W. am Ende, Uthpala Seneviratne, Zhen Huang, Armand B. Cognetta, Douglas S. Johnson, Daisuke Ogasawara, Kimberly Lapham, Benjamin F. Cravatt, John Litchfield, Deane M. Nason
Publikováno v:
ACS Chemical Biology. 14:192-197
Clinical investigation of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10–2474 resulted in serious adverse neurological events. Structurally unrelated FAAH inhibitors tested in humans have not presented safety concerns, suggesting that BIA 1
Autor:
Jacqueline R. Benthuysen, Vincent F. Vartabedian, Alex Reed, Hugh Rosen, Benjamin F. Cravatt, Amanda J. Roberts, Daisuke Ogasawara, Olesya A. Ulanovskaya, Hui Jing, Taka-Aki Ichu, Jonathan J. Hulce, John R. Teijaro, Steven D. Brown
Publikováno v:
Nature chemical biology
ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12(−/−) mice display PHARC-like phenotypes, including hearing loss, al
Autor:
Steven H. Liang, Michael A. Schafroth, Jian Rong, Ahmed Haider, Linjing Mu, Daisuke Ogasawara, Cassis Varlow, Hao Xu, Christopher J. Fowler, Neil Vasdev, Lu Hou, Jiefeng Gan, Lu Wang, Benjamin F. Cravatt, Ming-Rong Zhang, Simon M. Ametamey
Publikováno v:
J Med Chem
The endocannabinoid system (ECS) is involved in a wide range of biological functions and is comprised of cannabinoid receptors and enzymes responsible for endocannabinoid synthesis and degradation. Over the past two decades, significant advances towa
Autor:
Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
Publikováno v:
Nature Chemical Biology, 16(6), 667-675
Nat Chem Biol
Nat Chem Biol
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858eb516053df2c6e71eaf7ba6acceef
https://www.nature.com/articles/s41589-020-0528-7
https://www.nature.com/articles/s41589-020-0528-7
Autor:
Osamu Iida, Mitsuyoshi Takahara, Yoshimitsu Soga, Keisuke Hirano, Yasutaka Yamauchi, Kan Zen, Daizo Kawasaki, Shinsuke Nanto, Hiroyoshi Yokoi, Masaaki Uematsu, Nobuyoshi Azuma, Makoto Nakahama, Junichi Tazaki, Tsuyoshi Miyazawa, Masashi Fukunaga, Takahide Suzuki, Nobuhiro Suematsu, Yoshinori Tsubakimoto, Taketsugu Tsuchiya, Atsushi Tosaka, Kyozo Inoue, Terutoshi Yamaoka, Masatsugu Nakano, Michiaki Higashitani, Daisuke Ogasawara, Kenji Suzuki, Yoshiaki Shintani, Yusuke Miyashita, Norihiko Shinozaki, Makoto Utsunomiya, Hiroki Takahashi
Publikováno v:
JACC: Cardiovascular Interventions. 9:828-834
Objectives This study sought to investigate the characteristics of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation for femoropopliteal (FP) lesions, and to examine 1-year prognosis after repeat endovascular therapy (re-EVT) for