Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Cheryl H. Arrowsmith"'
Autor:
Bryan J. Fraser, Serap Beldar, Almagul Seitova, Ashley Hutchinson, Dhiraj Mannar, Yanjun Li, Daniel Kwon, Ruiyan Tan, Ryan P. Wilson, Karoline Leopold, Sriram Subramaniam, Levon Halabelian, Cheryl H. Arrowsmith, François Bénard
Publikováno v:
Nature Chemical Biology. 18:963-971
Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell factor for viral entry and pathogenesis of SARS-CoV-2. Specifically, TMPRSS2 proteolytically processes the SARS-CoV-2 Spike (S) protein, enabling virus-host membrane fusi
Autor:
Rachel Harding, M.K. Mann, Ahmed Aman, Carlos Zepeda-Velázquez, Brian J. Wilson, Taira Kiyota, Cheryl H. Arrowsmith, Peter Loppnau, Rima Al-awar, Matthieu Schapira, Héctor González-Álvarez, Yanjun Li, Aiping Dong
Publikováno v:
Journal of Medicinal Chemistry. 64:15017-15036
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Autor:
Aiping Dong, Levon Halabelian, Cheryl H. Arrowsmith, Yanjun Li, Ute Kothe, Hong Zeng, Hong Wu, Julia Guegueniat
Publikováno v:
Nucleic Acids Research
Nucleic Acids Res
Nucleic Acids Res
The human pseudouridine synthase PUS7 is a versatile RNA modification enzyme targeting many RNAs thereby playing a critical role in development and brain function. Whereas all target RNAs of PUS7 share a consensus sequence, additional recognition ele
Autor:
Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown
Publikováno v:
SLAS Discovery. 26:947-960
SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate and regulate several nonhist
Autor:
Peter Lin, Cornelia Redel, David W. Andrews, Yong Wei, Maria Sunnerhagen, Roberto Ciaccio, Alannah S MacDonald, Diana Resetca, Linda Z. Penn, Tristan M G Kenney, Corey Lourenco, Brian Raught, Cheryl H. Arrowsmith
Publikováno v:
Nature Reviews Cancer. 21:579-591
The transcription factor and oncoprotein MYC is a potent driver of many human cancers and can regulate numerous biological activities that contribute to tumorigenesis. How a single transcription factor can regulate such a diverse set of biological pr
Autor:
Jian Jin, Levon Halabelian, Fengling Li, Masoud Vedadi, Rima Al-awar, Carlo C. dela Seña, Mohammad S. Eram, Aiping Dong, Carlos Zepeda-Velázquez, He Chen, Matthieu Schapira, Robert M. Campbell, Dalia Barsyte-Lovejoy, David McLeod, Cheryl H. Arrowsmith, Hong Zeng, Hong Wu, Yudao Shen, Mary M. Mader, Viacheslav V. Trush, Brian Morgan Watson, Kwang-Su Park, Irene Chau, Fanye Meng, Peter Brown, H. Ümit Kaniskan, Magdalena M. Szewczyk
Publikováno v:
J Med Chem
Protein arginine methyltransferase 6 (PRMT6) catalyzes monomethylation and asymmetric dimethylation of arginine residues in various proteins, plays important roles in biological processes, and is associated with multiple cancers. To date, a highly se
Autor:
Nhat Tran, Heather Whetstone, Ian Restall, Patty Sachamitr, Julian Spears, Jasmin Coulombe-Huntington, Joseph Veyhl, Gary D. Bader, Mark Bernstein, Ahmed Aman, Mike Tyers, Hannes L. Röst, Sunit Das, Kirsten Hart, Bang-Chi Duong, Zahid Quyoom Bonday, Mathieu Lupien, Peter B. Dirks, Cheryl H. Arrowsmith, Maria M. Mangos, Laura M. Richards, Owen Whitley, Paul Guilhamon, María Sánchez-Osuna, H. Artee Luchman, Trevor J. Pugh, Jolene Caifeng Ho, Michael D. Cusimano, Samuel Weiss, Philippe Thibault, Amy Caudy, Olga Zaslaver, Panagiotis Prinos, Fiona J. Coutinho, Florence M.G. Cavalli, Wenjun Chen, Victoria Vu, Dalia Barsyte-Lovejoy, Xiaoyang Lan, Xinghui Che, Mathieu Durand, Michelle Kushida, Naghmeh Rastegar, Katlin B. Massirer, Benjamin Haibe-Kains, Lilian Lee, Evgeny Kanshin, Wail Ba-alawi, Felipe Ciamponi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogona
Autor:
Wail Ba-alawi, Evelyne Lima-Fernandes, Jason W. Locasale, Daniel D. De Carvalho, Paul Savage, Ilias Ettayebi, Hellen Kuasne, Morag Park, Felicia Tai, Yunchi Ingrid Kao, Benjamin Haibe-Kains, Alexandra N. Fedor, Paul Guilhamon, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Cheryl H. Arrowsmith, Xiaojing Liu, Constanza Martinez, Anne-Marie Fortier, Mathieu Lupien, Alex Murison, Geneviève Deblois, David W. Cescon
Publikováno v:
Cancer Discovery. 10:1312-1329
Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant
Autor:
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Publikováno v:
Redox Biol
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency
Autor:
Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M G Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David W Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H Arrowsmith, Linda Z Penn
Publikováno v:
Nucleic Acids Res
Despite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remain an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation, chromatin occupanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f19d6ab1ba39214c07c185c458d1acd
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183749
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183749