Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Antao Chang"'
Autor:
Liang Zhao, Min Kang, Xiaomeng Liu, Zhenran Wang, Yan Wang, Haiqiang Chen, Wenhui Liu, Shiqian Liu, Baibei Li, Chong Li, Antao Chang, Bo Tang
Publikováno v:
Journal of Experimental & Clinical Cancer Research. 41
Background Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiquitin–proteasome system faci
Autor:
Dan Wu, Dongmei Cheng, Shan Huang, Peiqing Sun, Juan Wang, Rong Xiang, Boris Pasche, Wei Zhang, Antao Chang, Guanwen Wang, Liang Liu, Stacey S O'Neill, Yanan Chen, Xiaoming Tan, William J. Petty, Justin M. Ashby
Publikováno v:
Cancer Res
When recruited to promoters, histone 3 lysine 4 (H3K4) methyltransferases KMT2 (KMT2A-D) activate transcription by opening chromatin through H3K4 methylation. Here, we report that KMT2 mutations occur frequently in non–small cell lung cancer (NSCLC
Autor:
Liangliang, Wu, Yi, Ge, Yudong, Yuan, Hui, Li, Huizhi, Sun, Chao, Xu, Yifei, Wang, Tiansuo, Zhao, Xiuchao, Wang, Jing, Liu, Song, Gao, Antao, Chang, Jihui, Hao, Chongbiao, Huang
Publikováno v:
Cancer Letters. 548:215864
Gemcitabine (GEM) resistance is one of the major causes of treatment failure in pancreatic ductal adenocarcinoma (PDAC) in clinic. Here, through CRISPR/Cas9 activation library screen, we found that MTA3 mediates the GEM resistance of PDAC and thus mi
Autor:
Guanwen Wang, Shan Huang, Rong Xiang, Yanhua Liu, Wen Shi, Mengyao Xu, Yanan Chen, Miao Li, Qiong Wang, Shuang Yang, Peiqing Sun, Chongbiao Huang, Antao Chang, Xiaoli Dong
Publikováno v:
Journal of Molecular Cell Biology
Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report t
Autor:
Guanwen Wang, Juan Wang, Antao Chang, Dongmei Cheng, Shan Huang, Dan Wu, Sherona Sirkisoon, Shuang Yang, Hui-Kuan Lin, Hui-Wen Lo, Rong Xiang, Peiqing Sun
Publikováno v:
Oncogene
While mechanisms for metastasis were extensively studied in cancer cells from patients with detectable tumors, pathways underlying metastatic dissemination from early lesions before primary tumors appear are poorly understood. Her2 promotes breast ca
Autor:
Chenchen Tian, Yufan Wei, Jianjun Li, Zhi Huang, Qiong Wang, Yingxue Lin, Xingping Lv, Yanan Chen, Yan Fan, Peiqing Sun, Rong Xiang, Antao Chang, Shuang Yang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2892
In recent years, three PARP inhibitors and three CDK4/6 inhibitors have been approved by the FDA for the treatment of recurrent ovarian cancer and advanced ER-positive breast cancer, respectively. However, the clinical benefits of the PARPi or CDK4/6
Autor:
Huimin Jiang, Huimin Wei, Hang Wang, Zhaoyang Wang, Jianjun Li, Yang Ou, Xuechun Xiao, Wenhao Wang, Antao Chang, Wei Sun, Li Zhao, Shuang Yang
Publikováno v:
Cell deathdisease. 13(3)
Aerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor progression by producing lactate, which has important roles as a proinflammatory and immunosuppressive mediator. However, how aerobic glycolysis is directly regulated i
Autor:
Shengyu Yang, Yang Xu, Jihui Hao, Antao Chang, Hongwei Wang, Tiansuo Zhao, Yang Li, Xiuchao Wang, Jie Dong, Na Li, Keping Xie, Chongbiao Huang, Yi Ge, He Ren, Zengxun Li
Publikováno v:
Clin Cancer Res
Purpose: Oxygen and glucose deprivation is a common feature of the solid tumor. Regulatory network underlying the adaptation of cancer cells to the harsh microenvironment remains unclear. We determined the mechanistic role of LIM and senescent cell a
Autor:
Rong Xiang, Zhenglu Wang, Renle Du, Shan Jiang, Yuzhi Shi, Ruifang Gao, Wenzhi Shen, Yan Fang, Antao Chang, Chenghu Liu, Lei Liu, Shuang Zhou, Na Li
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 8, Iss 5, Pp 2325-2337 (2019)
Cancer Medicine, Vol 8, Iss 5, Pp 2325-2337 (2019)
Toll‐like receptor 4 (TLR4) plays an essential role in cancer progress. Here, we find that the expression of TLR4 in relapsed human hepatocellular carcinoma (HCC) clinical samples is higher than that in the non‐relapsed ones, which leads us to ex
Autor:
Dongmei Cheng, Dan Wu, Xiaoming Tan, Shan Huang, Peiqing Sun, Qiong Wang, Rong Xiang, Shaorong Zhao, Antao Chang, Juan Wang, Guanwen Wang, Shuang Yang, Andy T Liu
Publikováno v:
Oncogene
Cancer can metastasize from early lesions without detectable tumors. Despite extensive studies on metastasis in cancer cells from patients with detectable primary tumors, mechanisms for early metastatic dissemination are poorly understood. Her2 promo