Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amelia J. Brennan"'
Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
Autor:
Daniela Castiblanco, Jesse A. Rudd-Schmidt, Tahereh Noori, Vivien R. Sutton, Ya Hui Hung, Thijs W. H. Flinsenberg, Adrian W. Hodel, Neil D. Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A. Trapani, Amelia J. Brennan, Ilia Voskoboinik
Publikováno v:
Blood. 139:1833-1849
Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol transporter, NPC1. Despite typically presenting with pronounced neurological manifestations, NP-C1 also resembles long-
Autor:
Wenbo Yu, Danushka K. Wijesundara, Ilia Voskoboinik, Jason Gummow, Branka Grubor-Bauk, Amelia J. Brennan, Eric J. Gowans, Tamsin J. Garrod
Publikováno v:
Gene Therapy. 23:26-37
Currently, no vaccine is available against hepatitis C virus (HCV), and although DNA vaccines have considerable potential, this has not been realised. Previously, the efficacy of DNA vaccines for human immunodeficiency virus (HIV) and HCV was shown t
Autor:
Alexander Dobrovic, Richard Saffery, Zac Chatterton, Ilia Voskoboinik, Kevin Y. T. Thia, Wei Z Yeh, Imran G House, Joseph A. Trapani, Amelia J. Brennan, Richard W. Tothill
Publikováno v:
Immunology & Cell Biology. 93:575-580
The production and delivery of functional perforin (PRF; PRF1 gene) by cytotoxic lymphocytes maintains immune homeostasis and tumour immune surveillance. In humans, inheritance of the common PRF1 polymorphism, p.A91V, (c.272C>T) found in 8-9% of the
Autor:
Amelia J. Brennan, Ilia Voskoboinik, Joseph A. Trapani, Jane Oliaro, Imran G House, Kelly M Ramsbottom, Magdalena Hagn, Hideo Yagita
Publikováno v:
The Journal of Immunology. 193:5744-5750
Cytotoxic lymphocytes destroy pathogen-infected and transformed cells through the cytotoxic granule exocytosis death pathway, which is dependent on the delivery of proapoptotic granzymes into the target cell cytosol by the pore-forming protein, perfo
Autor:
Amelia J. Brennan, Kevin R. Nicholas, David B. Ascher, Julie A. Sharp, Galina Polekhina, Christophe Lefevre
Publikováno v:
Cellular signalling. 33
α-lactalbumin is a protein of dual function found in milk of most mammals. α-lactalbumin binds β-1,4-galactosyltransferase to form the regulatory subunit for lactose synthesis and has also been shown to cause cell death. This study shows, for the
Autor:
Raymond S. Norton, Eleanor W. W. Leung, Annette Ciccone, Matthew A. Perugini, Natalya Lukoyanova, Hideo Yagita, Gordon J. Lloyd, Jamie A. Lopez, Joseph A. Trapani, Daouda A K Traore, James C. Whisstock, Sandra Verschoor, Kylie A. Browne, Con Dogovski, Ruby H. P. Law, Ilia Voskoboinik, Amelia J. Brennan
Publikováno v:
Biochemical Journal. 456:323-335
Following its secretion from cytotoxic lymphocytes into the immune synapse, perforin binds to target cell membranes through its Ca2+-dependent C2 domain. Membrane-bound perforin then forms pores that allow passage of pro-apoptopic granzymes into the
Publikováno v:
Critical reviews in immunology. 35(4)
A synapse is a specialized structure that forms when the plasma membrane of two cells come into close contact to facilitate communication and signaling. Cells of the immune system form 'immunological' synapses that have an ordered structure and are e
Autor:
Olivia Susanto, James C. Whisstock, Sarah Ellis, Kylie A. Browne, Ilia Voskoboinik, Joseph A. Trapani, Sandra Verschoor, Jenny Chia, Hideo Yagita, Annette Ciccone, Jamie A. Lopez, Amelia J. Brennan
Publikováno v:
Immunity. 34:879-892
SummaryCytotoxic lymphocyte-mediated apoptosis is dependent on the delivery of perforin to secretory granules and its ability to form calcium-dependent pores in the target cell after granule exocytosis. It is unclear how cytotoxic lymphocytes synthes
Autor:
Danushka K. Wijesundara, Branka Grubor-Bauk, Ranajoy Mullick, Tamsin J. Garrod, Amelia J. Brennan, Jason Gummow, Eric J. Gowans, Wenbo Yu, Ilia Voskoboinik, Yanrui Li
Publikováno v:
IndraStra Global.
There are 3 to 4 million new hepatitis C virus (HCV) infections annually around the world, but no vaccine is available. Robust T-cell mediated responses are necessary for effective clearance of the virus, and DNA vaccines result in a cell-mediated bi
Autor:
Colin M. House, Daniella Brasacchio, Joseph A. Trapani, Amelia J. Brennan, Tahereh Noori, Ricky W. Johnstone, Olivia Susanto, Phillip I. Bird, Kaylene J. Simpson
The human lymphocyte toxins granzyme B (hGrzB) and perforin cooperatively induce apoptosis of virus-infected or transformed cells: perforin pores enable entry of the serine protease hGrzB into the cytosol, where it processes Bid to selectively activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e9c0ec389effa935ec481639758dd6
https://europepmc.org/articles/PMC3978306/
https://europepmc.org/articles/PMC3978306/