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pro vyhledávání: '"Shyam Srivats"'
Autor:
J. Michael Edwardson, Colin W. Taylor, Gerard Vistal, Dilshan Balasuriya, Ruth D. Murrell-Lagnado, Shyam Srivats, Mathias Pasche
Publikováno v:
The Journal of Cell Biology
Sigma1 receptors inhibit store-operated Ca2+ entry and reduce the Ca2+ content of the intracellular stores. These effects are regulated by Sigma1 receptor ligands. A ligand-dependent interaction between Sigma1R and STIM1 reduces STIM1 association wit
Publikováno v:
FEBS letters. 588(17)
Depletion of Ca2+ from the endoplasmic reticulum (ER) lumen triggers the opening of Ca2+ release-activated Ca2+ (CRAC) channels at the plasma membrane. CRAC channels are activated by stromal interaction molecule 1 (STIM1), an ER resident protein that