Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael A. O'Reilly"'
Autor:
Rachel Warren, Gloria S. Pryhuber, Andrew M. Dylag, Jeannie Haak, Min Yee, Michael A. O'Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home with normal
Autor:
Maximilian Strunz, Paulina Ogar, Zhongming Zhao, Meshal Ansari, Herbert B. Schiller, Jens Neumann, Min Yee, Gerald Burgstaller, Marius Lange, I. V. Kukhtevich, Laura F. Mattner, Carola Voss, Ilias Angelidis, Arunima Sengupta, Michael A. O'Reilly, Robert J. Schneider, Christoph H. Mayr, Lukas M. Simon, Fabian J. Theis, Mareike Lehmann, Tobias Stoeger, Harold A. Chapman, Jürgen Behr, George Tsidiridis, Melanie Königshoff, Anne Hilgendorff, Jaymin J. Kathiriya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
bioRxiv
article-version (status) pre
article-version (number) 1
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
bioRxiv
article-version (status) pre
article-version (number) 1
The severity of COVID-19 lung disease is higher in the elderly and people with pre-existing co-morbidities. People who were born preterm may be at greater risk for COVID-19 because their early exposure to oxygen at birth increases their risk of being
Autor:
Aitor Nogales, Robert Gelein, Min Yee, Luis Martinez-Sobrido, Michael A. O'Reilly, Ravi S. Misra, William Domm
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L940-L949
Infants born prematurely often require supplemental oxygen, which contributes to aberrant lung development and increased pulmonary morbidity following a respiratory viral infection. We have been using a mouse model to understand how early-life hypero
Autor:
Rachel Warren, Michael A. O'Reilly
Publikováno v:
Am J Respir Cell Mol Biol
Human SCGB1A1 protein has been shown to be significantly reduced in BAL, sputum, and serum from humans with asthma as compared with healthy individuals. However, the mechanism of this reduction and its functional impact have not been entirely elucida
Autor:
Min Yee, R. Matthew Kottmann, Michael A. O'Reilly, Patricia J. Sime, Karen L. de Mesy Bentley, William Domm, B. Paige Lawrence, Robert Gelein
Publikováno v:
American journal of respiratory cell and molecular biology. 56(4)
An aberrant oxygen environment at birth increases the severity of respiratory viral infections later in life through poorly understood mechanisms. Here, we show that alveolar epithelial cell (AEC) 2 cells (AEC2s), progenitors for AEC1 cells, are depl
Autor:
Pierre Saintigny, Waun Ki Hong, John V. Heymach, Erminia Massarelli, Yuan Ping, Young Ho Ahn, Scott M. Lippman, Roy S. Herbst, Edward S. Kim, Carmen Behrens, Ignacio I. Wistuba, Steven H. Lin, J. Jack Lee, Luisa M. Solis Soto, Jonathan M. Kurie, Yulong Chen, Li Zhang, Ja Seok Koo, Diane Liu, Michael S. O'Reilly, Baruch Erez, Sangeeta Goswami
Publikováno v:
Cancer Research. 73:571-582
CXCR2 in non–small cell lung cancer (NSCLC) has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. Here, we examined the prognostic importance of CXCR2 in NSCLC and the role of CXCR2 and its ligands i
Publikováno v:
Clinical and Vaccine Immunology. 19:1432-1441
Supplemental oxygen administered to preterm infants is an important clinical intervention, but it is associated with life-long changes in lung development and increased sensitivity to respiratory viral infections. The precise immunological changes ca
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 177:1103-1110
Lungs of adult mice exposed to hyperoxia as newborns are simplified and exhibit reduced function much like that observed in people who had bronchopulmonary dysplasia (BPD) as infants. Because survivors of BPD also show increased risk for symptomatic
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L32-L40
Transgenic (TG) human (h) extracellular superoxide dismutase (EC-SOD) targeted to type II cells protects postnatal newborn mouse lung development against hyperoxia by unknown mechanisms. Because alveolar development depends on timely proliferation of