Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael A. O'Reilly"'
Autor:
Matthew D. McGraw, Min Yee, So-Young Kim, Andrew M. Dylag, B. Paige Lawrence, Michael A. O’Reilly
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(5)
Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop following exposure to toxic chemicals as well as respiratory tract infections. BO development is strongly associated with diacetyl (DA) inhalation exposures
Autor:
Rachel Warren, Gloria S. Pryhuber, Andrew M. Dylag, Jeannie Haak, Min Yee, Michael A. O'Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home with normal
Autor:
Rachel Warren, Andrew M. Dylag, Molly Behan, William Domm, Min Yee, Margot Mayer-Pröschel, Luis Martinez-Sobrido, Michael A. O’Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Children and young adults with mutant forms of ataxia telangiectasia mutated (ATM), a kinase involved in DNA damage signaling and mitochondrial homeostasis, suffer from recurrent respiratory infections, immune deficiencies, and obstructive airways di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cdbea1d72d8a5e4a016cf32a3bfdb4
https://europepmc.org/articles/PMC8993527/
https://europepmc.org/articles/PMC8993527/
Autor:
Aitor Nogales, Robert Gelein, Min Yee, Luis Martinez-Sobrido, Michael A. O'Reilly, Ravi S. Misra, William Domm
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L940-L949
Infants born prematurely often require supplemental oxygen, which contributes to aberrant lung development and increased pulmonary morbidity following a respiratory viral infection. We have been using a mouse model to understand how early-life hypero
Autor:
Agnieszka Pazderska, Mark Sherlock, Anjuli Gunness, Kevin Moore, L. A. Behan, Angela E Taylor, James Gibney, Niamh Phelan, Gerard Boran, Wiebke Arlt, Anne McGowan, Merina Ahmed, Michael W O'Reilly
Publikováno v:
Human reproduction (Oxford, England). 33(9)
STUDY QUESTION What information does androgen profiling using liquid chromatography tandem mass spectrometry (LC-MS/MS) provide in reproductive-age women with Type 1 diabetes (T1D)? SUMMARY ANSWER In T1D women, androstenedione proved most useful of t
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L716-L724
Prolonged exposure to hyperoxia inhibits cell proliferation in G1via increased expression of p21. While p21 inhibits proliferating cell nuclear antigen (PCNA)-dependent DNA synthesis, it can also directly lower PCNA abundance; however, it is unclear
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L32-L40
Transgenic (TG) human (h) extracellular superoxide dismutase (EC-SOD) targeted to type II cells protects postnatal newborn mouse lung development against hyperoxia by unknown mechanisms. Because alveolar development depends on timely proliferation of
Publikováno v:
Journal of Applied Physiology. 99:1226-1232
Mechanical strain is necessary for normal lung growth and development. Individuals with respiratory failure are supported with mechanical ventilation, leading to altered lung growth and injury. Understanding signaling pathways initiated by mechanical
Publikováno v:
Antioxidants & Redox Signaling. 7:719-725
Exposure to chronic oxidative stress during elevated oxygen (hyperoxia) damages DNA and inhibits cell proliferation in G(1) through induction of the cyclin-dependent kinase inhibitor p21. Cells that fail to express p21 growth-arrest in S phase. The o
Autor:
Michael A. O'Reilly
Publikováno v:
Antioxidants & Redox Signaling. 7:108-118
Cell division requires the coordinated assembly of cyclins and cyclin-dependent kinases that promote cell-cycle progression through S phase and mitosis. Two families of cyclin-dependent kinase inhibitors prevent abnormal or premature proliferation by