Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Maria Sasvari-Szekely"'
Autor:
Zsolt Ronai, Zsuzsanna Molnár, Gergely Keszler, Anna Szekely, Maria Sasvari-Szekely, Eszter Kotyuk
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226228 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226228 (2019)
Background Galanin, an inhibitory neuropeptide and cotransmitter has long been known to co-localize with noradrenaline and serotonin in the central nervous system. Several human studies demonstrated altered galanin expression levels in major depressi
Publikováno v:
Journal of Neural Transmission. 119:17-24
Histone deacetylase inhibitors are promising anti-tumor agents partly due to their ability to disrupt the hypoxic signaling pathway in human malignancies. However, little is known about any effects of these drugs on the central nervous system. The ai
Publikováno v:
Journal of Chromatography A. 1079:41-49
The investigation of the genetic background and phenotype structures of complex diseases, such as cardiovascular or psychiatric disorders and tumors, is one of the most scrutinized fields of the post genomic era. Besides the multiplex analysis of gen
Autor:
Gergely Keszler, Maria Staub, Iannis Talianidis, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Zsolt Csapó, Staffan Eriksson
Publikováno v:
Biochemical Pharmacology. 67:947-955
Deoxycytidine kinase (dCK), the principal deoxynucleoside salvage enzyme, plays a seminal role in the bioactivation of a wide array of cytotoxic nucleoside analogues. Recently, activation of dCK has been considered as a protective cellular response t
Autor:
Judit Gervai, Eszter Szantai, Zsolt Ronai, Maria Sasvari-Szekely, Zsofia Nemoda, András Guttman, Anna Szekely, R. Szmola
Publikováno v:
American Journal of Medical Genetics. :74-78
The polymorphic 5′ upstream region of the dopamine D4 receptor (DRD4) gene containing several single nucleotide polymorphisms (SNPs) has recently become a focus of association studies in psychiatric genetics. Most SNP genotyping methods are based o
Autor:
Gergely Keszler, Zsolt Csapó, Maria Staub, Géza Sáfrány, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Iannis Talianidis
Publikováno v:
Biochemical Pharmacology. 65:2031-2039
Deoxycytidine kinase (dCK) is a key enzyme in the intracellular metabolism of deoxynucleosides and their analogues, phosphorylating a wide range of drugs used in the chemotherapy of leukaemia and solid tumours. Previously, we found that activity of d
Publikováno v:
International journal of immunogenetics. 41(6)
Summary Several lines of evidence suggest that certain subtypes of obsessive-compulsive and tic disorders might be paediatric manifestations of post-streptococcal autoimmunity caused by cross-reactive autoantibodies. As tumor necrosis factor (TNF) is
Publikováno v:
Molecular Genetics and Metabolism. 74:484-488
Decreased activity of plasma cholinesterase is responsible for prolonged apnea during anesthesia using neuromuscular blockers such as suxamethonium and mivacurium. More than 20 mutations have been identified so far in the BCHE gene resulting in impai
Autor:
Zsolt Ronai, Maria Sasvari-Szekely, Erika Kovács, Anna Szekely, Zsofia Nemoda, András Guttman, Sarah Shandrick
Publikováno v:
ELECTROPHORESIS. 22:4008-4011
Large-scale genotyping of the repeat polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) was attempted by polymerase chain reaction (PCR) amplification followed by gel microchip electrophoresis analysis. The multilane (
Autor:
Melinda Szoke, Ágnes Turi, Maria Sasvari-Szekely, Zsolt Csapó, Staffan Eriksson, Maria Staub, Tatjana Spasokoukotskaja, Ildiko Szanto
Publikováno v:
Biochemical Pharmacology. 56:1175-1179
Deoxycytidine kinase (dCK, EC.2.7.1.74), a key enzyme in intracellular metabolism of many antileukemic drugs, was shown to be activated during treatment of lymphocytes by 2-chloro-2'-deoxyadenosine (Cl-dAdo, cladribine), a potent inhibitor of DNA syn