Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Carmen Garnacho"'
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(7)
Acid sphingomyelinase deficiency in type B Niemann-Pick disease leads to lysosomal sphingomyelin storage, principally affecting lungs, liver, and spleen. Infused recombinant enzyme is beneficial, yet its delivery to the lungs is limited and requires
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:1178-1185
Objective— Engagement of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells by ICAM-1-targeted carriers induces cell adhesion molecule–mediated endocytosis, providing intraendothelial delivery of therapeutics. This pathway differs fr
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 340:638-647
Intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein expressed on activated endothelium and many other cells, represents a suitable target for delivery of drug nanocarriers (NCs) to disease areas. Numerous works have shown efficie
Autor:
Yang Shen, Tridib Kumar Bhowmick, Carmen Garnacho, Daniel Serrano, Janet Hsu, Yuan-Chia Kuo, Silvia Muro, Kishan Kumar
Publikováno v:
Journal of Controlled Release. 149:323-331
Fabry disease, due to the deficiency of α-galactosidase A (α-Gal), causes lysosomal accumulation of globotriaosylceramide (Gb3) in multiple tissues and prominently in the vascular endothelium. Although enzyme replacement therapy (ERT) by injection
Autor:
Carmen Garnacho, John Leferovich, Edward H. Schuchman, Christine Gajewski, Julie A. Champion, Vladimir R. Muzykantov, Samir Mitragotri, Silvia Muro
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 16(8)
Endocytosis in endothelial cells (ECs) is important for many biomedical applications, including drug delivery by nano- and microscale carriers. However, little is known about how carrier geometry influences endothelial drug targeting, intracellular t
Autor:
Carmen Garnacho, Vladimir V. Shuvaev, Steven M. Albelda, Silvia Muro, Michael Koval, Vladimir R. Muzykantov, Anu P. Thomas, Jing Sun, Lindsay McKenna
Publikováno v:
Blood. 111(6)
Platelet-endothelial cell adhesion molecule-1 (PECAM-1), a transmembrane glycoprotein involved in leukocyte transmigration, represents a good target for endothelial drug delivery (eg, using antibody-directed nanocarriers, anti-PECAM/NCs). Although en