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Publikováno v:
International Journal of Oral and Maxillofacial Surgery. 51:713-723
Melatonin receptors can inhibit breast and prostate cancers; however, little is known regarding their effects on oral squamous cell carcinoma. In this study, we collected specimens from 81 patients with oral squamous cell carcinoma and analysed clini
Autor:
Parthiban Marimuthu, Thirugnanasambandham Sivasubramanian Anitha, Mugilarasi Purushothaman, Muralidharan A Ramachandran, Daisy S. Precilla, Shreyas S Kuduvalli
Publikováno v:
Current Molecular Pharmacology. 15:338-360
Background: Glioblastoma Multiforme (GBM) is one of the most heterogeneous primary brain tumors with high mortality. In spite of the current therapeutic approaches, the survival rate remains poor, with death occurring within 12 to 15 months after the
Autor:
Mark Jason De Jesus, Mandy Rickard, Jin Kyu Kim, Michael Chua, Joana Dos Santos, Armando J. Lorenzo, Jun S. Dy, Min Joon Lee, Jessica M. Ming
Publikováno v:
Journal of Urology. 207:524-533
ß3-adrenergic receptor agonists (ß3 agonists) have been used in treatment of overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in adults. However, their use in children has only recently been approved by the U.S. Food and Drug Adm
Autor:
Emily Kessler, Rodrigo Saad-Berreta, Hongwu Zheng, Vikram Deshpande, Krishna S. Tummala, Brandon Nicolay, William Shen, Ramzi Adil, Meng-Ju Wu, Juan Dubrot, Lipika Goyal, Vajira Weeresekara, Amaya Pankaj, Mathias Heikenwalder, Tong Wang, Mirian Fernandez-Vaquero, María García-Beccaria, Ting-Yu Wei, Kira E Olander, Sebastien Ronseaux, Vindhya Vijay, Qibiao Wu, Yuanli Zhen, Christine Hudson, Nabeel Bardeesy, Lei Shi, Rahul M. Kohli, Meiqi Luo, Yi Sun, Russell W. Jenkins, Robert T. Manguso, Cristina R. Ferrone, Joshua Merritt
Publikováno v:
Cancer Discovery. 12:812-835
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma. (R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits multiple α-ketoglutarate–dependent enzymes, altering epigenetics and metabolism. Here, by developing mIDH1
Autor:
Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v:
Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Autor:
Julien Mazieres, Patrik Vitazka, Lyudmila Bazhenova, Pasi A. Jänne, Misako Nagasaka, DESTINY-Lung Trial Investigators, Enriqueta Felip, Luis Paz-Ares, Ryota Shiga, Yingkai Cheng, Yasushi Goto, Kapil Saxena, Kazuhiko Nakagawa, Maurice Pérol, Javad Shahidi, Jose M. Pacheco, Bob T. Li, David Planchard, Hibiki Udagawa, Egbert F. Smit, Suddhasatta Acharyya, Andreas Saltos
Publikováno v:
DESTINY-Lung01 Trial Investigators 2022, ' Trastuzumab deruxtecan in HER2-mutant non–small-cell lung cancer ', New England Journal of Medicine, vol. 386, no. 3, pp. 241-251 . https://doi.org/10.1056/NEJMoa2112431
N Engl J Med
New England Journal of Medicine. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine
The New England journal of medicine, vol 386, iss 3
New England Journal of Medicine, 386(3), 241-251. Massachussetts Medical Society
N Engl J Med
New England Journal of Medicine. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine
The New England journal of medicine, vol 386, iss 3
New England Journal of Medicine, 386(3), 241-251. Massachussetts Medical Society
Background Human epidermal growth factor receptor 2 (HER2)-targeted therapies have not been approved for patients with non-small-cell lung cancer (NSCLC). The efficacy and safety of trastuzumab deruxtecan (formerly DS-8201), a HER2 antibody-drug conj
Autor:
Sunil J. Advani, Hyunho Yoon, Rowan Ustoy, Mayra Yebra, Vipul R. Sheth, Sudeep Banerjee, Michael Heinrich, Christian M. Metallo, Joseph A. Aguilera, Sangkyu Noh, Scott M. Lippman, Razelle Kurzrock, Chih-Min Tang, Olivier Harismendy, Paul T. Fanta, Adam M. Burgoyne, Avi Kumar, Thekla Cordes, Shruti Bhargava, Sam Li, Jason K. Sicklick, Christopher L. Corless
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Purpose: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A–D) comprising less than 7.5% (i.e., 150–200/year) of new cases annually in the United S
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 250-257 (2022)
FEBS Open Bio
FEBS Open Bio
Acetylcholine (ACh), an excitatory neurotransmitter, is biosynthesized from choline in cholinergic neurons. Import from the extracellular space to the intracellular environment through the high‐affinity choline transporter is currently regarded to
Publikováno v:
Neuroscience. 480:56-64
Morphine is an opioid drug often used in treating moderate to severe pain. However, morphine tolerance in patients limits its used in clinical settings. Our previous study showed that a cannabinoid type 2 (CB2) receptor agonist attenuated morphine to
Autor:
Lucie Kolářová, Maya Shemesh, Yoav Peleg, Pavel Mikulecký, Maroš Huličiak, Gideon Schreiber, Bohdan Schneider, Jiří Zahradník
Publikováno v:
The FEBS Journal. 289:2672-2684
We hereby describe the process of design and selection of non-antibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN-λ1, type 3 interferon (also known as IL-29) for its novelty and the importance of its biological