Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Tanja D de Gruijl"'
Publikováno v:
Cancer Immunology, Immunotherapy
Rotman, J, Koster, B D, Jordanova, E S, Heeren, A M & de Gruijl, T D 2019, ' Unlocking the therapeutic potential of primary tumor-draining lymph nodes ', Cancer Immunology, Immunotherapy, vol. 68, no. 10, pp. 1681-1688 . https://doi.org/10.1007/s00262-019-02330-y
Rotman, J, Koster, B D, Jordanova, E S, Heeren, A M & de Gruijl, T D 2019, ' Unlocking the therapeutic potential of primary tumor-draining lymph nodes ', Cancer Immunology, Immunotherapy, vol. 68, no. 10, pp. 1681-1688 . https://doi.org/10.1007/s00262-019-02330-y
Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tu
Autor:
Koen Van de Vijver, Anne Marijne Heeren, Sanne Samuels, Maaike C. G. Bleeker, Tanja D. de Gruijl, Jossie Rotman, Gemma G. Kenter, Guus Fons, H. J. M. A. A. Zijlmans, Ekaterina J Jordanova
Publikováno v:
Journal for Immunotherapy of Cancer, 9(10):e003623. BioMed Central
Heeren, A M, Rotman, J, Samuels, S, Zijlmans, H J M A A, Fons, G, Van De Vijver, K K, Bleeker, M C G, Kenter, G G, Jordanova, E J & De Gruijl, T D 2021, ' Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth ', Journal for Immunotherapy of Cancer, vol. 9, no. 10, e003623 . https://doi.org/10.1136/jitc-2021-003623
Journal for immunotherapy of cancer, 9(10):e003623. BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
JOURNAL FOR IMMUNOTHERAPY OF CANCER
Heeren, A M, Rotman, J, Samuels, S, Zijlmans, H J M A A, Fons, G, Van De Vijver, K K, Bleeker, M C G, Kenter, G G, Jordanova, E J & De Gruijl, T D 2021, ' Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth ', Journal for Immunotherapy of Cancer, vol. 9, no. 10, e003623 . https://doi.org/10.1136/jitc-2021-003623
Journal for immunotherapy of cancer, 9(10):e003623. BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
JOURNAL FOR IMMUNOTHERAPY OF CANCER
BackgroundTherapeutic immune intervention is highly dependent on the T-cell priming and boosting capacity of tumor-draining lymph nodes (TDLN). In vulvar cancer, in-depth studies on the immune status of (pre)metastatic TDLN is lacking.MethodsWe have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a549388d783f72acec6d84918181b5a0
https://research.vumc.nl/en/publications/7f5455c0-d175-4438-95ce-eade7181a18a
https://research.vumc.nl/en/publications/7f5455c0-d175-4438-95ce-eade7181a18a
Autor:
Maartje Van Ruiten, Nienke E. van Trommel, Ekaterina S. Jordanova, John B. A. G. Haanen, Ton N. Schumacher, Gemma G. Kenter, Jossie Rotman, Marc van Beurden, Noor A. M. Bakker, Sanne Samuels, Bastiaan Nuijen, Karin E. de Visser, Tanja D. de Gruijl, Jos H. Beijnen, Henry Zijlmans, Joost H. van den Berg
Publikováno v:
Bakker, N A M, Rotman, J, Van Beurden, M, Zijlmans, H J M A A, Van Ruiten, M, Samuels, S, Nuijen, B, Beijnen, J, De Visser, K, Haanen, J, Schumacher, T, De Gruijl, T D, Jordanova, E S, Kenter, G G, Van Den Berg, J H & Van Trommel, N E 2021, ' HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN) : A phase I/II clinical trial ', Journal for Immunotherapy of Cancer, vol. 9, no. 8, 002547 . https://doi.org/10.1136/jitc-2021-002547
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Journal for Immunotherapy of Cancer, 9(8):002547. BioMed Central
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Journal for Immunotherapy of Cancer, 9(8):002547. BioMed Central
Journal for Immunotherapy of Cancer
BackgroundUsual vulvar intraepithelial neoplasia (uVIN) is a premalignancy caused by persistent infection with high-risk types of human papillomavirus (HPV), mainly type 16. Even though different treatment modalities are available (eg, surgical excis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb52bf3c6adfbc91bc3923e54b6cf18
https://research.vumc.nl/en/publications/835225f1-3bfb-4c3a-80d9-30f8b85de4ca
https://research.vumc.nl/en/publications/835225f1-3bfb-4c3a-80d9-30f8b85de4ca
Autor:
Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodríguez, Anno Saris, Eline S. Zwart, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, 12
European Journal of Immunology, 51, 409-409. Wiley-VCH Verlag
Frontiers in immunology, 12:697840. Frontiers Media S.A.
Affandi, A J, Olesek, K, Grabowska, J, Nijen Twilhaar, M K, Rodríguez, E, Saris, A, Zwart, E S, Nossent, E J, Kalay, H, de Kok, M, Kazemier, G, Stöckl, J, van den Eertwegh, A J M, de Gruijl, T D, Garcia-Vallejo, J J, Storm, G, van Kooyk, Y & den Haan, J M M 2021, ' CD169 Defines Activated CD14 + Monocytes With Enhanced CD8 + T Cell Activation Capacity ', Frontiers in Immunology, vol. 12, 697840, pp. 697840 . https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840
Frontiers in Immunology, 12:697840. Frontiers Research Foundation
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 12, 1. Frontiers Media S.A.
Frontiers in Immunology, 12:697840. Frontiers Media S.A.
Affandi, A, Olesek, K, Grabowska, J, Twilhaar, M N, Rodriguez, E, Saris, A, Zwart, E, Nossent, E, Kalay, H, De Kok, M, Kazemier, G, Stockl, J, Van den Eertwegh, A, De Gruijl, T, Vallejo, J G, Storm, G, Van Kooyk, Y & Den Haan, J 2021, ' CD169 defines activated CD14+monocytes with enhanced CD8+T cell activation capacity ', European Journal of Immunology, vol. 51, pp. 409-409 .
European Journal of Immunology, 51, 409-409. Wiley-VCH Verlag
Frontiers in immunology, 12:697840. Frontiers Media S.A.
Affandi, A J, Olesek, K, Grabowska, J, Nijen Twilhaar, M K, Rodríguez, E, Saris, A, Zwart, E S, Nossent, E J, Kalay, H, de Kok, M, Kazemier, G, Stöckl, J, van den Eertwegh, A J M, de Gruijl, T D, Garcia-Vallejo, J J, Storm, G, van Kooyk, Y & den Haan, J M M 2021, ' CD169 Defines Activated CD14 + Monocytes With Enhanced CD8 + T Cell Activation Capacity ', Frontiers in Immunology, vol. 12, 697840, pp. 697840 . https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840, https://doi.org/10.3389/fimmu.2021.697840
Frontiers in Immunology, 12:697840. Frontiers Research Foundation
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 12, 1. Frontiers Media S.A.
Frontiers in Immunology, 12:697840. Frontiers Media S.A.
Affandi, A, Olesek, K, Grabowska, J, Twilhaar, M N, Rodriguez, E, Saris, A, Zwart, E, Nossent, E, Kalay, H, De Kok, M, Kazemier, G, Stockl, J, Van den Eertwegh, A, De Gruijl, T, Vallejo, J G, Storm, G, Van Kooyk, Y & Den Haan, J 2021, ' CD169 defines activated CD14+monocytes with enhanced CD8+T cell activation capacity ', European Journal of Immunology, vol. 51, pp. 409-409 .
Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ecba359f231a1291a57423a4591bfb
https://research.vumc.nl/en/publications/b32063d7-e476-4274-ab71-e89b7d4ea6f0
https://research.vumc.nl/en/publications/b32063d7-e476-4274-ab71-e89b7d4ea6f0
Publikováno v:
van Pul, K M, Fransen, M F, van de Ven, R & de Gruijl, T D 2021, ' Immunotherapy Goes Local : The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy ', Frontiers in Immunology, vol. 12, 643291, pp. 643291 . https://doi.org/10.3389/fimmu.2021.643291
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance has been related to a lack of T cells infiltrating into the tumor. Strategies to overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5daeb36ebe7bc070244de75184778a9
https://research.vumc.nl/en/publications/c1861d0d-26a3-4232-aaf8-661efa5296a2
https://research.vumc.nl/en/publications/c1861d0d-26a3-4232-aaf8-661efa5296a2
Autor:
Paul Hamberg, John B. A. G. Haanen, Hans van Vliet, Metin Tascilar, Zuhir Bodalal, Tanja D. de Gruijl, Carla M.L. van Herpen, Henk M.W. Verheul, Sinéad M. Lougheed, Charlotte M. Huijts
Publikováno v:
Huijts, C M, Lougheed, S M, Bodalal, Z, van Herpen, C M, Hamberg, P, Tascilar, M, Haanen, J B, Verheul, H M, de Gruijl, T D, van der Vliet, H J & Dutch WIN-O Consortium 2019, ' The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial ', Cancer Immunology, Immunotherapy, vol. 68, no. 3, pp. 503-515 . https://doi.org/10.1007/s00262-018-2288-8
Cancer Immunology, Immunotherapy, 68(3), 503-515. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 503-515
Cancer Immunology Immunotherapy, 68, 3, pp. 503-515
Cancer Immunology, Immunotherapy, 68(3), 503-515. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 503-515
Cancer Immunology Immunotherapy, 68, 3, pp. 503-515
For the treatment of metastatic renal cell cancer several strategies are used among which the mTOR inhibitor everolimus. As mTOR plays an important role in the immune system, e.g., by controlling the expression of the transcription factor FoxP3 there
Autor:
Tanja D. de Gruijl, Susan Gibbs, Judith L A Burm, Elisabetta Michielon, Ekaterina S. Jordanova, Marta López González, Taco Waaijman
Publikováno v:
Cancer Immunology, Immunotherapy, 69(11), 2319-2331. Springer Science and Business Media Deutschland GmbH
Michielon, E, López González, M, Burm, J L A, Waaijman, T, Jordanova, E S, de Gruijl, T D & Gibbs, S 2020, ' Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10 ', Cancer Immunology, Immunotherapy, vol. 69, no. 11, pp. 2319-2331 . https://doi.org/10.1007/s00262-020-02626-4
Cancer Immunology, Immunotherapy
Michielon, E, López González, M, Burm, J L A, Waaijman, T, Jordanova, E S, de Gruijl, T D & Gibbs, S 2020, ' Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10 ', Cancer Immunology, Immunotherapy, vol. 69, no. 11, pp. 2319-2331 . https://doi.org/10.1007/s00262-020-02626-4
Cancer Immunology, Immunotherapy
Preclinical assessment of novel therapies to fight cancer requires models that reflect the human physiology and immune response. Here, we established an in vitro three-dimensional (3D) reconstructed organotypic human melanoma-in-skin (Mel-RhS) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb39af4083cbc3e967d27a97862f019c
https://research.vu.nl/en/publications/d4df51cd-2f0e-4a20-8ec6-e0b556e31501
https://research.vu.nl/en/publications/d4df51cd-2f0e-4a20-8ec6-e0b556e31501
Autor:
Monique T A de Beijer, M. Petrousjka van den Tol, Kim M van Pul, Rieneke van de Ven, Ronald J.C.L.M. Vuylsteke, Hein B.A.C. Stockmann, Tanja D. de Gruijl
Publikováno v:
Journal for Immunotherapy of Cancer, 8(2):000761. BioMed Central
Journal for Immunotherapy of Cancer
van Pul, K M, Vuylsteke, R J C L M, de Beijer, M T A, van de Ven, R, van den Tol, M P, Stockmann, H B A C & de Gruijl, T D 2020, ' Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway ', Journal for Immunotherapy of Cancer, vol. 8, no. 2, 000761 . https://doi.org/10.1136/jitc-2020-000761
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
van Pul, K M, Vuylsteke, R J C L M, de Beijer, M T A, van de Ven, R, van den Tol, M P, Stockmann, H B A C & de Gruijl, T D 2020, ' Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway ', Journal for Immunotherapy of Cancer, vol. 8, no. 2, 000761 . https://doi.org/10.1136/jitc-2020-000761
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundWe previously showed selectively hampered activation of lymph node-resident (LNR) dendritic cell (DC) subsets in the breast cancer (BrC) sentinel lymph node (SLN) to precede a state of profound T cell anergy. Reactivating these DC subsets b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3406d127ed9680898546a4cfcfa188d4
https://research.vumc.nl/en/publications/4c2dbfc6-2b07-413f-b709-813762f6d5a3
https://research.vumc.nl/en/publications/4c2dbfc6-2b07-413f-b709-813762f6d5a3
Autor:
Charles G. Drake, Walter J. Urba, David Kaufman, Leisha A. Emens, Jeffrey S. Weber, Alessandra Cesano, Douglas G. McNeel, Ana C. Anderson, Marcela V. Maus, Mario Sznol, Jon M Wiggington, Lisa H. Butterfield, Patrick Hwu, David Parkinson, Ernest C. Borden, James L. Gulley, Michael J. Mastrangelo, Michael B. Atkins, Kim Margolin, Julie R. Brahmer, Thomas F. Gajewski, Robert O. Dillman, Pedro Romero, Daniel S. Chen, Francesco M. Marincola, George J. Weiner, Paolo A. Ascierto, Tanja D. de Gruijl, Michael T. Lotze, Paul M. Sondel, F. Stephen Hodi, Bernard A. Fox, Stefani Spranger, Howard L. Kaufman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for immunotherapy of cancer, vol. 8, no. 1
Ascierto, P A, Fox, B, Urba, W, Anderson, A C, Atkins, M B, Borden, E C, Brahmer, J, Butterfield, L H, Cesano, A, Chen, D, De Gruijl, T, Dillman, R O, Drake, C G, Emens, L A, Gajewski, T F, Gulley, J L, Stephen Hodi, F, Hwu, P, Kaufman, D, Kaufman, H, Lotze, M, McNeel, D G, Margolin, K, Marincola, F, Mastrangelo, M J, Maus, M V, Parkinson, D R, Romero, P J, Sondel, P M, Spranger, S, Sznol, M, Weiner, G J, Wiggington, J M & Weber, J S 2020, ' Insights from immuno-oncology : The Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19 ', Journal for Immunotherapy of Cancer, vol. 8, no. 1, e000878 . https://doi.org/10.1136/jitc-2020-000878
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer
Journal for immunotherapy of cancer, vol. 8, no. 1
Ascierto, P A, Fox, B, Urba, W, Anderson, A C, Atkins, M B, Borden, E C, Brahmer, J, Butterfield, L H, Cesano, A, Chen, D, De Gruijl, T, Dillman, R O, Drake, C G, Emens, L A, Gajewski, T F, Gulley, J L, Stephen Hodi, F, Hwu, P, Kaufman, D, Kaufman, H, Lotze, M, McNeel, D G, Margolin, K, Marincola, F, Mastrangelo, M J, Maus, M V, Parkinson, D R, Romero, P J, Sondel, P M, Spranger, S, Sznol, M, Weiner, G J, Wiggington, J M & Weber, J S 2020, ' Insights from immuno-oncology : The Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19 ', Journal for Immunotherapy of Cancer, vol. 8, no. 1, e000878 . https://doi.org/10.1136/jitc-2020-000878
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer
The hypoxia and profound inflammatory response associated with the pneumonitis observed with the severe acute respiratory virus coronavirus-2 (SARS-COV-2) virus responsible for the recent COVID-19 pandemic has overwhelmed intensive care facilities in
Autor:
Dorian A. Stolk, Aram de Haas, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Stolk, D A, de Haas, A, Vree, J, Duinkerken, S, Lübbers, J, van de Ven, R, Ambrosini, M, Kalay, H, Bruijns, S, van der Vliet, H J, de Gruijl, T D & van Kooyk, Y 2020, ' Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T-and iNKT Cell Responses ', Frontiers in Immunology, vol. 11, 990 . https://doi.org/10.3389/fimmu.2020.00990
Frontiers in Immunology
Frontiers in Immunology, 11:990
Stolk, D A, de Haas, A, Vree, J, Duinkerken, S, Lübbers, J, van de Ven, R, Ambrosini, M, Kalay, H, Bruijns, S, van der Vliet, H J, de Gruijl, T D & van Kooyk, Y 2020, ' Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T-and iNKT Cell Responses ', Frontiers in Immunology, vol. 11, 990 . https://doi.org/10.3389/fimmu.2020.00990
Frontiers in Immunology
Frontiers in Immunology, 11:990
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells