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Autor:
J. Mielke, Robert A. Quinn, Lo M. Sosinski, Douglas V. Guzior, Kerri A. Neugebauer, Marc McClelland, Alicia Castillo-Bahena, Lydia-Ann J. Ghuneim, Ryan Thomas, Doug Conrad, Christian Martin H
Publikováno v:
Journal of Cystic Fibrosis. 21:996-1005
Background Elexacaftor-Tezacaftor-Ivacaftor (ETI) therapy is showing promising efficacy for treatment of cystic fibrosis (CF) and is becoming more widely available since recent FDA approval. However, little is known about how these drugs will affect
Autor:
Johan Frostegård
Publikováno v:
Journal of Internal Medicine. 293:48-62
The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment and care, but cardiovascular disease (CVD) still remains an important clinical problem, since the risk of CVD in SLE is much higher than among controls. Atherosc
Autor:
Aamir Ahmad, Aftab Ahmad, Nithya Mariappan, Shama Ahmad, Shajer Manzoor, Simmone Siddiqui, Iram Zafar
Publikováno v:
Seminars in Cancer Biology
Inflammation is an essential component of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). It is central to lung cancer, the leading cancer in terms of associat
Autor:
Scott T. Weiss, Nancy Laranjo, Megan Sandel, Babak Momeni, Kathleen Lee-Sarwar, Sandra Dedrick, Diane R. Gold, Robert S. Zeiger, Jessica Lasky-Su, Yang-Yu Liu, Leonard B. Bacharier, George T. O'Connor, Rachel S. Kelly, Augusto A. Litonjua, Avraham Beigelman
Publikováno v:
Journal of Allergy and Clinical Immunology. 150:325-336
While the microbiome has an established role in asthma development, less is known about its contribution to morbidity in children with asthma.In this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we analyzed the gut micr
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 22:1619-1630
Abstract: Sarcoidosis is a worldwide inflammatory disorder of unknown etiology that is characterized by the formation of non-caseating immune granulomas in involved organs, most commonly in the lungs and eyes. Although clinical manifestations of sarc
Autor:
J Borbujo, M A Tejedor-Alonso, P Terradas, Marta Ferrer, Manuel Velasco, Joan Bartra, E. Serra-Baldrich, Ignacio Jáuregui, F J Muñoz-Bellido, J Pedraz, M Labrador, A. Giménez-Arnau, I Figueras
Publikováno v:
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Objective: During its first year, the AWARE study assessed disease activity, patient quality of life (QOL), and treatment patterns in chronic urticaria (CU) refractory to H1-antihistamines (H1-AH) in clinical practice. Methods: We performed an observ
Autor:
Cassianne Robinson-Cohen, David C. Christiani, S. Alice Long, Carmen Mikacenic, Carolyn S. Calfee, Mark M. Wurfel, James A. Russell, Alison E Fohner, Jason D. Christie, Victoria Dmyterko, Keith R. Walley, Pavan K. Bhatraju, Susanna Kosamo, Nuala J. Meyer, Karen Cerosaletti, Michael A. Matthay
Publikováno v:
Crit Care Med
OBJECTIVES Multiple organ failure in critically ill patients is associated with poor prognosis, but biomarkers contributory to pathogenesis are unknown. Previous studies support a role for Fas cell surface death receptor (Fas)-mediated apoptosis in o
Publikováno v:
Eur J Endocrinol
Context A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression neither for viral susceptib
Autor:
Charles R. Esther, Wanda K. O’Neal, Wayne H. Anderson, Mehmet Kesimer, Agathe Ceppe, Claire M. Doerschuk, Neil E. Alexis, Annette T. Hastie, R. Graham Barr, Russell P. Bowler, J. Michael Wells, Elizabeth C. Oelsner, Alejandro P. Comellas, Yohannes Tesfaigzi, Victor Kim, Laura M. Paulin, Christopher B. Cooper, MeiLan K. Han, Yvonne J. Huang, Wassim W. Labaki, Jeffrey L. Curtis, Richard C. Boucher, Mehrdad Arjomandi, Igor Barjaktarevic, Lori A. Bateman, Surya P. Bhatt, Eugene R. Bleecker, Stephanie A. Christenson, David J. Couper, Gerard J. Criner, Ronald G. Crystal, Mark T. Dransfield, Brad Drummond, Christine M. Freeman, Craig Galban, Nadia N. Hansel, Eric A. Hoffman, Yvonne Huang, Robert J. Kaner, Richard E. Kanner, Eric C. Kleerup, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Fernando J. Martinez, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Robert Paine, Laura Paulin, Stephen P. Peters, Cheryl Pirozzi, Nirupama Putcha, Victor E. Ortega, Sanjeev Raman, Stephen I. Rennard, Donald P. Tashkin, Robert A. Wise, Prescott G. Woodruff
Publikováno v:
Chest
Chest, vol 161, iss 5
Chest, vol 161, iss 5
BACKGROUND: Improved understanding of the pathways associated with airway pathophysiologic features in COPD will identify new predictive biomarkers and novel therapeutic targets. RESEARCH QUESTION: Which physiologic pathways are altered in the airway
Autor:
Alun Barton, William O.C.M. Cookson, Rebecca C Hull, Michael R. Loebinger, James D. Chalmers, Holly R. Keir, Huw Ellis, Jeffrey T.-J. Huang, Miriam F. Moffatt
Publikováno v:
Chest. 161:1180-1191
Nontuberculous mycobacterial (NTM) infections are difficult to diagnose and treat. Biomarkers to identify patients with active infection or at risk of disease progression would have clinical utility. Sputum is the most frequently used matrix for the