Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tanja D de Gruijl"'
Autor:
Nathalie van Leeuwen-Kerkhoff, Shahram Kordasti, Theresia M. Westers, Giovanni A M Povoleri, Tanja D. de Gruijl, Pino J Poddighe, Arjan A. van de Loosdrecht, Jessica A Timms
Publikováno v:
Haematologica, 107(3), 655-667. Ferrata Storti Foundation
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, Povoleri, G A M, Timms, J A, Kordasti, S, de Gruijl, T D & van de Loosdrecht, A A 2022, ' Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes ', Haematologica, vol. 107, no. 3, pp. 655-667 . https://doi.org/10.3324/haematol.2020.268136
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, Povoleri, G A M, Timms, J A, Kordasti, S, de Gruijl, T D & van de Loosdrecht, A A 2022, ' Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes ', Haematologica, vol. 107, no. 3, pp. 655-667 . https://doi.org/10.3324/haematol.2020.268136
In myelodysplastic syndromes (MDS) the immune system is involved in pathogenesis as well as in disease progression. Dendritic cells (DC) are key players of the immune system by serving as regulators of immune responses. Their function has been scarce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5391dba937cb802184434c01c08a37
https://research.vumc.nl/en/publications/db725181-9627-4bb8-b6d6-30678dae82ff
https://research.vumc.nl/en/publications/db725181-9627-4bb8-b6d6-30678dae82ff
Autor:
Arjan A. van de Loosdrecht, Tanja D. de Gruijl, Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Shahram Kordasti
Publikováno v:
Haematologica
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, de Gruijl, T D, Kordasti, S & van de Loosdrecht, A A 2020, ' Thrombomodulin expressing monocytes are associated with low risk features in myelodysplastic syndromes and dampen excessive immune activation ', Haematologica, vol. 105, no. 4, pp. 961-970 . https://doi.org/10.3324/haematol.2019.219303
Haematologica, 105(4), 961-970. Ferrata Storti Foundation
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, de Gruijl, T D, Kordasti, S & van de Loosdrecht, A A 2020, ' Thrombomodulin expressing monocytes are associated with low risk features in myelodysplastic syndromes and dampen excessive immune activation ', Haematologica, vol. 105, no. 4, pp. 961-970 . https://doi.org/10.3324/haematol.2019.219303
Haematologica, 105(4), 961-970. Ferrata Storti Foundation
The bone marrow of patients with low-risk myelodysplastic syndromes (MDS) is often an inflammatory environment and associated with an active cellular immune response. An active immune response generally contributes to antitumor responses and may prev
Publikováno v:
Cancer Immunology, Immunotherapy
Rotman, J, Koster, B D, Jordanova, E S, Heeren, A M & de Gruijl, T D 2019, ' Unlocking the therapeutic potential of primary tumor-draining lymph nodes ', Cancer Immunology, Immunotherapy, vol. 68, no. 10, pp. 1681-1688 . https://doi.org/10.1007/s00262-019-02330-y
Rotman, J, Koster, B D, Jordanova, E S, Heeren, A M & de Gruijl, T D 2019, ' Unlocking the therapeutic potential of primary tumor-draining lymph nodes ', Cancer Immunology, Immunotherapy, vol. 68, no. 10, pp. 1681-1688 . https://doi.org/10.1007/s00262-019-02330-y
Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tu
Autor:
Koen Van de Vijver, Anne Marijne Heeren, Sanne Samuels, Maaike C. G. Bleeker, Tanja D. de Gruijl, Jossie Rotman, Gemma G. Kenter, Guus Fons, H. J. M. A. A. Zijlmans, Ekaterina J Jordanova
Publikováno v:
Journal for Immunotherapy of Cancer, 9(10):e003623. BioMed Central
Heeren, A M, Rotman, J, Samuels, S, Zijlmans, H J M A A, Fons, G, Van De Vijver, K K, Bleeker, M C G, Kenter, G G, Jordanova, E J & De Gruijl, T D 2021, ' Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth ', Journal for Immunotherapy of Cancer, vol. 9, no. 10, e003623 . https://doi.org/10.1136/jitc-2021-003623
Journal for immunotherapy of cancer, 9(10):e003623. BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
JOURNAL FOR IMMUNOTHERAPY OF CANCER
Heeren, A M, Rotman, J, Samuels, S, Zijlmans, H J M A A, Fons, G, Van De Vijver, K K, Bleeker, M C G, Kenter, G G, Jordanova, E J & De Gruijl, T D 2021, ' Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth ', Journal for Immunotherapy of Cancer, vol. 9, no. 10, e003623 . https://doi.org/10.1136/jitc-2021-003623
Journal for immunotherapy of cancer, 9(10):e003623. BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
JOURNAL FOR IMMUNOTHERAPY OF CANCER
BackgroundTherapeutic immune intervention is highly dependent on the T-cell priming and boosting capacity of tumor-draining lymph nodes (TDLN). In vulvar cancer, in-depth studies on the immune status of (pre)metastatic TDLN is lacking.MethodsWe have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a549388d783f72acec6d84918181b5a0
https://research.vumc.nl/en/publications/7f5455c0-d175-4438-95ce-eade7181a18a
https://research.vumc.nl/en/publications/7f5455c0-d175-4438-95ce-eade7181a18a
Publikováno v:
van Pul, K M, Fransen, M F, van de Ven, R & de Gruijl, T D 2021, ' Immunotherapy Goes Local : The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy ', Frontiers in Immunology, vol. 12, 643291, pp. 643291 . https://doi.org/10.3389/fimmu.2021.643291
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance has been related to a lack of T cells infiltrating into the tumor. Strategies to overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5daeb36ebe7bc070244de75184778a9
https://research.vumc.nl/en/publications/c1861d0d-26a3-4232-aaf8-661efa5296a2
https://research.vumc.nl/en/publications/c1861d0d-26a3-4232-aaf8-661efa5296a2
Autor:
Paul Hamberg, John B. A. G. Haanen, Hans van Vliet, Metin Tascilar, Zuhir Bodalal, Tanja D. de Gruijl, Carla M.L. van Herpen, Henk M.W. Verheul, Sinéad M. Lougheed, Charlotte M. Huijts
Publikováno v:
Huijts, C M, Lougheed, S M, Bodalal, Z, van Herpen, C M, Hamberg, P, Tascilar, M, Haanen, J B, Verheul, H M, de Gruijl, T D, van der Vliet, H J & Dutch WIN-O Consortium 2019, ' The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial ', Cancer Immunology, Immunotherapy, vol. 68, no. 3, pp. 503-515 . https://doi.org/10.1007/s00262-018-2288-8
Cancer Immunology, Immunotherapy, 68(3), 503-515. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 503-515
Cancer Immunology Immunotherapy, 68, 3, pp. 503-515
Cancer Immunology, Immunotherapy, 68(3), 503-515. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 503-515
Cancer Immunology Immunotherapy, 68, 3, pp. 503-515
For the treatment of metastatic renal cell cancer several strategies are used among which the mTOR inhibitor everolimus. As mTOR plays an important role in the immune system, e.g., by controlling the expression of the transcription factor FoxP3 there
Autor:
Tanja D. de Gruijl, Susan Gibbs, Judith L A Burm, Elisabetta Michielon, Ekaterina S. Jordanova, Marta López González, Taco Waaijman
Publikováno v:
Cancer Immunology, Immunotherapy, 69(11), 2319-2331. Springer Science and Business Media Deutschland GmbH
Michielon, E, López González, M, Burm, J L A, Waaijman, T, Jordanova, E S, de Gruijl, T D & Gibbs, S 2020, ' Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10 ', Cancer Immunology, Immunotherapy, vol. 69, no. 11, pp. 2319-2331 . https://doi.org/10.1007/s00262-020-02626-4
Cancer Immunology, Immunotherapy
Michielon, E, López González, M, Burm, J L A, Waaijman, T, Jordanova, E S, de Gruijl, T D & Gibbs, S 2020, ' Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10 ', Cancer Immunology, Immunotherapy, vol. 69, no. 11, pp. 2319-2331 . https://doi.org/10.1007/s00262-020-02626-4
Cancer Immunology, Immunotherapy
Preclinical assessment of novel therapies to fight cancer requires models that reflect the human physiology and immune response. Here, we established an in vitro three-dimensional (3D) reconstructed organotypic human melanoma-in-skin (Mel-RhS) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb39af4083cbc3e967d27a97862f019c
https://research.vu.nl/en/publications/d4df51cd-2f0e-4a20-8ec6-e0b556e31501
https://research.vu.nl/en/publications/d4df51cd-2f0e-4a20-8ec6-e0b556e31501
Autor:
Monique T A de Beijer, M. Petrousjka van den Tol, Kim M van Pul, Rieneke van de Ven, Ronald J.C.L.M. Vuylsteke, Hein B.A.C. Stockmann, Tanja D. de Gruijl
Publikováno v:
Journal for Immunotherapy of Cancer, 8(2):000761. BioMed Central
Journal for Immunotherapy of Cancer
van Pul, K M, Vuylsteke, R J C L M, de Beijer, M T A, van de Ven, R, van den Tol, M P, Stockmann, H B A C & de Gruijl, T D 2020, ' Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway ', Journal for Immunotherapy of Cancer, vol. 8, no. 2, 000761 . https://doi.org/10.1136/jitc-2020-000761
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
van Pul, K M, Vuylsteke, R J C L M, de Beijer, M T A, van de Ven, R, van den Tol, M P, Stockmann, H B A C & de Gruijl, T D 2020, ' Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway ', Journal for Immunotherapy of Cancer, vol. 8, no. 2, 000761 . https://doi.org/10.1136/jitc-2020-000761
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundWe previously showed selectively hampered activation of lymph node-resident (LNR) dendritic cell (DC) subsets in the breast cancer (BrC) sentinel lymph node (SLN) to precede a state of profound T cell anergy. Reactivating these DC subsets b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3406d127ed9680898546a4cfcfa188d4
https://research.vumc.nl/en/publications/4c2dbfc6-2b07-413f-b709-813762f6d5a3
https://research.vumc.nl/en/publications/4c2dbfc6-2b07-413f-b709-813762f6d5a3
Autor:
Dorian A. Stolk, Aram de Haas, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Stolk, D A, de Haas, A, Vree, J, Duinkerken, S, Lübbers, J, van de Ven, R, Ambrosini, M, Kalay, H, Bruijns, S, van der Vliet, H J, de Gruijl, T D & van Kooyk, Y 2020, ' Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T-and iNKT Cell Responses ', Frontiers in Immunology, vol. 11, 990 . https://doi.org/10.3389/fimmu.2020.00990
Frontiers in Immunology
Frontiers in Immunology, 11:990
Stolk, D A, de Haas, A, Vree, J, Duinkerken, S, Lübbers, J, van de Ven, R, Ambrosini, M, Kalay, H, Bruijns, S, van der Vliet, H J, de Gruijl, T D & van Kooyk, Y 2020, ' Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T-and iNKT Cell Responses ', Frontiers in Immunology, vol. 11, 990 . https://doi.org/10.3389/fimmu.2020.00990
Frontiers in Immunology
Frontiers in Immunology, 11:990
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells
Autor:
R. Eveline Li, Sjoerd T.T. Schetters, Floortje J. van Haften, Fabrizio Chiodo, Tanja D. de Gruijl, Yvette van Kooyk, Sanne Duinkerken
Publikováno v:
Duinkerken, S, Li, RJE, van Haften, F J, de Gruijl, TD, Chiodo, F, Schetters, STT & van Kooyk, Y 2019, ' Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells ', Current Opinion Chemical Biology, vol. 53, pp. 167-172 . https://doi.org/10.1016/j.cbpa.2019.10.001
Dendritic cell (DC)–targeting vaccines show great promise in increasing antitumor immunity. Glycan-engineered vaccines facilitate both DC targeting and increased uptake by DCs for processing and presentation to CD4+ and CD8+ T cells to induce tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fbeb8814fc80080b2186c39597bd18
https://research.vumc.nl/en/publications/b0f27eba-339e-493e-969c-d95d284c4fd5
https://research.vumc.nl/en/publications/b0f27eba-339e-493e-969c-d95d284c4fd5