Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Bing, Ren"'
Autor:
Maria C. Costanzo, Marcin von Grotthuss, Jeffrey Massung, Dongkeun Jang, Lizz Caulkins, Ryan Koesterer, Clint Gilbert, Ryan P. Welch, Parul Kudtarkar, Quy Hoang, Andrew P. Boughton, Preeti Singh, Ying Sun, Marc Duby, Annie Moriondo, Trang Nguyen, Patrick Smadbeck, Benjamin R. Alexander, MacKenzie Brandes, Mary Carmichael, Peter Dornbos, Todd Green, Kenneth C. Huellas-Bruskiewicz, Yue Ji, Alexandria Kluge, Aoife C. McMahon, Josep M. Mercader, Oliver Ruebenacker, Sebanti Sengupta, Dylan Spalding, Daniel Taliun, Philip Smith, Melissa K. Thomas, Beena Akolkar, M. Julia Brosnan, Andriy Cherkas, Audrey Y. Chu, Eric B. Fauman, Caroline S. Fox, Tania Nayak Kamphaus, Melissa R. Miller, Lynette Nguyen, Afshin Parsa, Dermot F. Reilly, Hartmut Ruetten, David Wholley, Norann A. Zaghloul, Gonçalo R. Abecasis, David Altshuler, Thomas M. Keane, Mark I. McCarthy, Kyle J. Gaulton, Jose C. Florez, Michael Boehnke, Noël P. Burtt, Jason Flannick, Gonçalo Abecasis, Nicholette D. Allred, Jennifer E. Below, Richard Bergman, Joline W.J. Beulens, John Blangero, Krister Bokvist, Erwin Bottinger, Donald Bowden, Christopher Brown, Kenneth Bruskiewicz, Inês Cebola, John Chambers, Yii-Der Ida Chen, Christopher Clark, Melina Claussnitzer, Nancy J. Cox, Marcel den Hoed, Duc Dong, Ravindranath Duggirala, Josée Dupuis, Petra J.M. Elders, Jesse M. Engreitz, Eric Fauman, Jorge Ferrer, Paul Flicek, Matthew Flickinger, Timothy M. Frayling, Kelly A. Frazer, Anna L. Gloyn, Craig L. Hanis, Robert Hanson, Andrew T. Hattersley, Hae Kyung Im, Sidra Iqbal, Suzanne B.R. Jacobs, Dong-Keun Jang, Tad Jordan, Tania Kamphaus, Fredrik Karpe, Seung K. Kim, Kasper Lage, Leslie A. Lange, Mitchell Lazar, Donna Lehman, Ching-Ti Liu, Ruth J.F. Loos, Ronald Ching-wan Ma, Patrick MacDonald, Matthew T. Maurano, Gil McVean, James B. Meigs, Braxton Mitchell, Karen L. Mohlke, Samuel Morabito, Claire Morgan, Shannon Mullican, Sharvari Narendra, Maggie C.Y. Ng, Colin N.A. Palmer, Stephen C.J. Parker, Antonio Parrado, Aaron C. Pawlyk, Ewan R. Pearson, Andrew Plump, Michael Province, Thomas Quertermous, Susan Redline, Bing Ren, Stephen S. Rich, J. Brent Richards, Jerome I. Rotter, Rany M. Salem, Maike Sander, Michael Sanders, Dharambir Sanghera, Laura J. Scott, David Siedzik, Xueling Sim, Robert Sladek, Kerrin Small, Peter Stein, Heather M. Stringham, Katalin Susztak, Leen M. ’t Hart, Kent Taylor, Jennifer A. Todd, Miriam S. Udler, Benjamin Voight, Andre Wan, Kaan Yuksel
Publikováno v:
710.e6
AMP-T2D Consortium 2023, ' The Type 2 Diabetes Knowledge Portal : An open access genetic resource dedicated to type 2 diabetes and related traits ', Cell Metabolism, vol. 35, no. 4, pp. 695-710.e6 . https://doi.org/10.1016/j.cmet.2023.03.001
Cell Metab
Cell metabolism, vol 35, iss 4
Cell Metabolism, 35(4), 695-710.e6. Cell Press
AMP-T2D Consortium 2023, ' The Type 2 Diabetes Knowledge Portal : An open access genetic resource dedicated to type 2 diabetes and related traits ', Cell Metabolism, vol. 35, no. 4, pp. 695-710.e6 . https://doi.org/10.1016/j.cmet.2023.03.001
Cell Metab
Cell metabolism, vol 35, iss 4
Cell Metabolism, 35(4), 695-710.e6. Cell Press
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories of these data seek to be disease-agnostic and therefore lack disease-focused views. The Type 2 Diabetes Knowledge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04094df70ceb068c99b961c7447fbab0
http://hdl.handle.net/10044/1/104941
http://hdl.handle.net/10044/1/104941
Autor:
Eugin Destici, Fugui Zhu, Shaina Tran, Sebastian Preissl, Elie N. Farah, Yanxiao Zhang, Xiameng Hou, Olivier B. Poirion, Ah Young Lee, Jonathan D. Grinstein, Joshua Bloomekatz, Hong Sook Kim, Robert Hu, Sylvia M. Evans, Bing Ren, Chris Benner, Neil C. Chi
Publikováno v:
Nature cardiovascular research, vol 1, iss 9
Nat Cardiovasc Res
Nat Cardiovasc Res
The heart, a vital organ which is first to develop, has adapted its size, structure and function in order to accommodate the circulatory demands for a broad range of animals. Although heart development is controlled by a relatively conserved network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2c11e2a8af24819d06933d0f9a1f28
https://escholarship.org/uc/item/6t922532
https://escholarship.org/uc/item/6t922532
Autor:
Yanxiao Zhang, Maria Luisa Amaral, Chenxu Zhu, Steven Francis Grieco, Xiaomeng Hou, Lin Lin, Justin Buchanan, Liqi Tong, Sebastian Preissl, Xiangmin Xu, Bing Ren
Publikováno v:
Cell research, vol 32, iss 11
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals; however, the specific cell types and gene loci affected by this type of epigenetic change have remained unclear. To a
Autor:
Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Tim Stuart, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Rivkin, Xinxin Wang, Jacinta Lucero, Joseph R. Nery, David A. Davis, Deborah C. Mash, Rahul Satija, Jesse R. Dixon, Sten Linnarsson, Ed Lein, M. Margarita Behrens, Bing Ren, Eran A. Mukamel, Joseph R. Ecker
Publikováno v:
Cell genomics, vol 2, iss 3
Single-cell technologies measure unique cellular signatures but are typically limited to a single modality. Computational approaches allow the fusion of diverse single-cell data types, but their efficacy is difficult to validate in the absence of aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8376ab73ba7a5c0256dd5e758198a060
https://escholarship.org/uc/item/56j017g9
https://escholarship.org/uc/item/56j017g9
Autor:
Kyle J. Gaulton, Nick Vinckier, Xiaoyu Li, Yimeng Yin, Jussi Taipale, Anugraha Raman, André M. Ribeiro dos Santos, Paola Benaglio, Jian Yan, Yang Eric Li, Kelly A. Frazer, Fulin Chen, Shicai Fan, Maike Sander, Joshua Chiou, Naoki Nariai, Bing Ren, Yunjiang Qiu
Publikováno v:
Nature. 591:147-151
Many sequence variants have been linked to complex human traits and diseases1, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have systematically assessed the binding of 270 human tran
Autor:
Paola Benaglio, Han Zhu, Mei-Lin Okino, Jian Yan, Ruth Elgamal, Naoki Nariai, Elisha Beebe, Katha Korgaonkar, Yunjiang Qiu, Margaret K.R. Donovan, Joshua Chiou, Gaowei Wang, Jacklyn Newsome, Jaspreet Kaur, Michael Miller, Sebastian Preissl, Sierra Corban, Anthony Aylward, Jussi Taipale, Bing Ren, Kelly A. Frazer, Maike Sander, Kyle J. Gaulton
Publikováno v:
Cell genomics, vol 2, iss 12
Publisher Copyright: © 2022 We combined functional genomics and human genetics to investigate processes that affect type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory cytokines. We mapped 38,931 cytokine-respon
Autor:
Poshen B. Chen, Patrick C. Fiaux, Kai Zhang, Bin Li, Naoki Kubo, Shan Jiang, Rong Hu, Emma Rooholfada, Sihan Wu, Mengchi Wang, Wei Wang, Graham McVicker, Paul S. Mischel, Bing Ren
Publikováno v:
Cell reports, vol 41, iss 6
A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to understanding how these cis-regulatory elements contribute to human diseases. We carry out highly multiplexed CRISPR-based perturbation and sequencing
Autor:
Rong Hu, Nam Nguyen, Jennifer Santini, Miao Yu, Hoon Kim, Xingqi Chen, Nathan M. Jameson, Roel G.W. Verhaak, Ramya Raviram, Yarui Diao, Howard Y. Chang, Kristen M. Turner, Frank B. Furnari, Julie A. Law, Jack Houston, Ceyda Coruh, Marcella L. Erb, Sihan Wu, Vineet Bafna, Zhen Ye, Jens Luebeck, Jeffrey M. Granja, Ming Hu, M. Ryan Corces, Paul S. Mischel, Bin Li, Wenjing Zhang, Armen Abnousi, Utkrisht Rajkumar, Bing Ren
Publikováno v:
Nature, vol 575, iss 7784
Nature
Nature
Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer1,2, but our understanding of the structure of ecDNA and its effect on gene regulation is limited. Here, by integrating ultrastructural imaging, long-range optical
Autor:
Li Yin, David Heckerman, Amalio Telenti, Ali Torkamani, Bing Ren, Jonathan Sebat, Julia di Iulio, Alex Wells
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. H
Autor:
Eliezer Masliah, Yarui Diao, Changyoun Kim, Tristin Liu, Samantha Kuan, Catherine L. Tan, Dongchan Yang, Zachary Chiang, Dongsup Kim, Sora Chee, Junghyun Eom, Marilynn Chan, Bin Li, Inkyung Jung, Cathy L. Barr, Bing Ren, Anthony D. Schmitt, Andrew J. Lee
Publikováno v:
Nature genetics
A large number of putative cis-regulatory sequences have been annotated in the human genome, but the genes they control remain poorly defined. To bridge this gap, we generate maps of long-range chromatin interactions centered on 18,943 well-annotated