Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yong J. Lee"'
Autor:
Marco A. Alcala, Jinsang Yoo, David L. Bartlett, Byeong-Chel Lee, Bae-Hang Park, Dae Hee Lee, Kyung Soo Park, Yong J. Lee
Publikováno v:
Journal of Cellular Biochemistry. 110:1073-1081
Approximately 25% of patients with colorectal cancer develop metastases to the liver, and surgery is currently the best treatment available. But there are several patients who are unresectable, and isolated hepatic perfusion (IHP) offers a different
Publikováno v:
Cancer Gene Therapy. 8:397-404
Tumor cells that express a fusion gene of Escherichia coli cytosine deaminase (CD) and herpes simplex virus type 1 thymidine kinase (TK) sequences activate and are subsequently killed by the nontoxic prodrugs 5-fluorocytosine and ganciclovir. We have
Autor:
Peter M. Corry, Yong J. Lee, Sandra Galoforo, Robert V. Blackburn, Joong M. Cho, Christine M. Berns, Mark E. Ireland
Publikováno v:
Molecular and Cellular Biochemistry. 155:51-60
We investigated the role of alpha B-crystallin expression in the development of thermotolerance in murine L929 cells. An initial heat-shock of 10 min at 45 degrees C induced thermotolerance in these cells to a heat challenge at 45 degrees C administe
Autor:
Michael J. Borrelli, Geza Erdos, Christine M. Berns, Peter M. Corry, Yong J. Lee, Chang H. Ahn
Publikováno v:
Biochemical Pharmacology. 48:2057-2063
The effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C (PKC) inhibitor, on the development of thermotolerance and expression of heat shock genes (HSP70 and HSP28) was investigated in human colon carcinoma HT-29 c
Publikováno v:
Journal of Cell Science. 107:2209-2214
We have investigated the regulation mechanism of chemical stress-induced hsp70 gene expression in murine L929 cells. Our data show that chemical treatments including sodium arsenite, cadmium chloride and sodium salicylate, induced significant synthes
Publikováno v:
Biochemical and Biophysical Research Communications. 199:714-719
The possible involvement of PKC in the regulation of heat shock genes expression was investigated with three isoquinolinesulfonamide derivatives (H-7, H-8, and HA1004) in DUT-145, MCF-7, and MCF-7/ADR cells. The drug was added 1 hr before and during
Publikováno v:
Journal of Cellular Physiology. 153:353-361
The constitutive HSP70 purified from CHO cells, which indicated a single band in SDS-polyacrylamide gel electrophoresis, showed multiple bands in native-polyacrylamide gel electrophoresis. These results indicate that the protein may exist in oligomer
Publikováno v:
Biochemical and Biophysical Research Communications. 186:1121-1128
When cells were heated for 15 min at 45 degrees C, they became thermotolerant to a second heat exposure at 45 degrees C. Thermotolerance developed rapidly, reached its maximum 6 hr after heat shock, and then gradually decayed. The development of ther
Publikováno v:
Journal of Cellular Physiology. 149:396-402
The mechanism of histidinol (HST)-induced heat protection was investigated to test the hypothesis that the cessation of protein synthesis itself is one of the events involved in heat protection. For this study, we isolated three HST-resistant mutant
Publikováno v:
Biochemical and Biophysical Research Communications. 177:575-581
Protein denaturation resulting from temperatures between 42.0 degrees C and 50 degrees C has been observed and implicated as the lethal lesion for hyperthermic cell killing. A logical corollary is that protection against hyperthermic killing requires