Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R. Scott Hawley"'
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 11, p e1008421 (2019)
PLoS Genetics, Vol 15, Iss 11, p e1008421 (2019)
Balancer chromosomes are multiply inverted and rearranged chromosomes that are widely used in Drosophila genetics. First described nearly 100 years ago, balancers are used extensively in stock maintenance and complex crosses. Recently, the complete m
Autor:
Katherine Kretovich Billmyre, G. Matthew Heenan, R. Scott Hawley, Jay R. Unruh, Zulin Yu, Satomi Takeo, Emily R. Wesley, Cori K. Cahoon
The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as the Drosophila melanogaster transvers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9029ed0b9571d1dae8af8252cbfab4ef
https://europepmc.org/articles/PMC6815145/
https://europepmc.org/articles/PMC6815145/
Autor:
R. Scott Hawley, Cathleen M. Lake
Publikováno v:
Seminars in Cell & Developmental Biology. 54:117-125
The proper execution of meiotic recombination (or crossing over) is essential for chromosome segregation during the first meiotic division, and thus this process is regulated by multiple, and often elaborate, mechanisms. Meiotic recombination begins
Autor:
Danny E. Miller, R. Scott Hawley
Publikováno v:
Current Biology. 27:R26-R28
In most sexually reproducing organisms, crossover formation between homologous chromosomes is necessary for proper chromosome disjunction during meiosis I. During meiotic recombination, a subset of programmed DNA double-strand breaks (DSBs) are repai
Publikováno v:
SSRN Electronic Journal.
In Drosophila, meiotic recombination is initiated by the formation of programmed DNA doublestrand breaks (DSBs), which occur within the context of the synaptonemal complex (SC). We created an in-frame deletion mutant in c(3)G (deleting amino acids L3
Autor:
Amanda M. Bonner, Kim S. McKim, Rachel J. Nielsen, Cathleen M. Lake, R. Scott Hawley, Sanese K. White-Brown, Salam Eche
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 1, p e1007886 (2019)
PLoS Genetics, Vol 15, Iss 1, p e1007886 (2019)
Meiotic recombination, which is necessary to ensure that homologous chromosomes segregate properly, begins with the induction of meiotic DNA double-strand breaks (DSBs) and ends with the repair of a subset of those breaks into crossovers. Here we inv
Autor:
R. Scott Hawley, Jeff Sekelsky, Stephanie P. Bellendir, Julie Korda Holsclaw, Cathleen M. Lake
Publikováno v:
G3: Genes|Genomes|Genetics
The recognition of DNA double-strand breaks (DSBs) using a phospho-specific antibody to the histone 2A variant has become the gold standard assay for DNA damage detection. Here we report on the development of the first monoclonal antibody to the phos
Autor:
R. Scott Hawley, Cathleen M. Lake
Publikováno v:
Annual Review of Physiology. 74:425-451
We review the critical events in early meiotic prophase in Drosophila melanogaster oocytes. We focus on four aspects of this process: the formation of the synaptonemal complex (SC) and its role in maintaining homologous chromosome pairings, the criti
Autor:
R. Scott Hawley, Fengli Guo, Cathleen M. Lake, Brian D. Slaughter, Jay R. Unruh, Rachel J. Nielsen
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
Meiotic recombination begins with the induction of programmed double-strand breaks (DSBs). In most organisms only a fraction of DSBs become crossovers. Here we report a novel meiotic gene, vilya, which encodes a protein with homology to Zip3-like pro
Autor:
Jennifer K. Jeffress, Lorinda K. Anderson, Suzanne M. Royer, Justin P. Blumenstiel, Scott L. Page, Elizabeth D. Belden, R. Scott Hawley
Publikováno v:
Genetics. 177:2445-2456
In Drosophila melanogaster oocytes, the C(3)G protein comprises the transverse filaments (TFs) of the synaptonemal complex (SC). Like other TF proteins, such as Zip1p in yeast and SCP1 in mammals, C(3)G is composed of a central coiled-coil-rich domai