Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shingo Kajimura"'
Autor:
Bo-Ruei Chen, Shingo Kajimura, David G. Schatz, Louis-Marie Charbonnier, Yinan Wang, Chun-Chin Chen, Jessica K. Tyler, Jaime de Juan-Sanz, Timothy A. Ryan, Philip Curman, Ryan M. Brecht, Catherine C. Liu, Talal A. Chatila, Ryan J. Farrell, Jakob D. Wikstrom, Barry P. Sleckman, Helen A. Beilinson
Publikováno v:
The Journal of Experimental Medicine
We show that the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) family proteins SERCA2 and SERCA3 have redundant functions that are required for RAG gene expression and DNA breaks during V(D)J recombination. Loss of SERCA activity leads to B lymphop
Autor:
Ayano Ueno, Kaori Igarashi, Huixia Li, Zhipeng Dai, Carlos H.G. Sponton, Tomoyoshi Soga, Momoko Yoneshiro, Qiang Wang, Zachary Brown, Takeshi Yoneshiro, Haruya Takahashi, Takamasa Ishikawa, Rachana N. Pradhan, Mito Kuroda, Kyeongkyu Kim, Olga Ilkayeva, Robert W. McGarrah, Michael T. McManus, Yann Deleye, Tsuyoshi Goto, Labros S. Sidossis, Vanille J. Greiner, Shingo Kajimura, Yong Chen, Maki Ohishi, Yasuo Oguri, Hiroko Maki, Phillip J. White, Francis C. Szoka, Maria Chondronikola, Mami Matsushita, Kazuki Tajima, Masayuki Saito, Teruo Kawada, Homa Majd, Kenji Ikeda
Publikováno v:
Nature, vol 572, iss 7771
Endocrinology
Endocrinology
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulatinglevels of BCAA are linked to obesity and diabetes. The mechanisms of this paradox remain unclear
Autor:
Daniel K. Nomura, Zachary Brown, Mark P. Jedrychowski, Makoto Takahashi, Yoko Yokoyama, Rachana N. Pradhan, Hiroshi Karasawa, Carlos H.G. Sponton, Qiang Wang, Mitsuhiro Watanabe, Yumi Matsui, Yong Chen, Hiroki Taoka, Kenji Ikeda, Kazuki Tajima, Kosaku Shinoda, Carl C. Ward, Takeshi Yoneshiro, Shingo Kajimura, Lindsay S. Roberts, Junki Taura, Yasuo Oguri, Takashi Hosono
Publikováno v:
EMBO Rep
While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of th
Autor:
Yong Chen, Kolapo M. Ajuwon, Tomoyoshi Soga, Qianqian Kang, Pema Maretich, Hiroko Maki, Kenji Ikeda, Xiaodan Lu, Kosaku Shinoda, Kazuki Tajima, Joao Paulo Camporez, Takeshi Yoneshiro, Mayu Homma, Shingo Kajimura
Publikováno v:
Nature Medicine. 23:1454-1465
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-depend
Autor:
James C. Lo, Sara Serag, Julia A. Tartaglia, Paul Cohen, Steven P. Gygi, Kosaku Shinoda, Shingo Kajimura, Mark P. Jedrychowski, Serkan Kir, Bruce M. Spiegelman, Katrin J. Svensson, Alain Chédotal, Jonathan Z. Long, Rajesh R. Rao
Publikováno v:
Cell Metabolism. 23(3):454-466
Activation of brown and beige fat can reduce obesity and improve glucose homeostasis through non-shivering thermogenesis. Whether brown or beige fat also secrete paracrine or endocrine factors to promote and amplify adaptive thermogenesis is not full
Autor:
Shingo Kajimura, Lawrence Kazak, Dina Laznik-Bogoslavski, Bruce M. Spiegelman, Paul Cohen, Mark P. Jedrychowski, Sebastian C. Hasenfuss, Ramalingam Vetrivelan, Kosaku Shinoda, Edward T. Chouchani, Steve P. Gygi, Brian K. Erickson, Gina Z. Lu
Publikováno v:
Cell. 163:643-655
SummaryThermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to cold of brown and beige adipose depots are examined using qua
Autor:
Carlos H.G. Sponton, Shingo Kajimura
Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4d6c9a45155a64ef580339d15db9e9
https://europepmc.org/articles/PMC6692864/
https://europepmc.org/articles/PMC6692864/
Autor:
Kenji Ikeda, Carlos H.G. Sponton, Kazuki Tajima, Qiang Wang, Yong Chen, Kyeongkyu Kim, Zachary Brown, Takeshi Yoneshiro, Kosaku Shinoda, Annarita Scaramozza, Shingo Kajimura, Andrew S. Brack
Publikováno v:
Nature, vol 565, iss 7738
Nature
Nature
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fiber-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose ti
Autor:
Diana L. Alba, Jingyi Chi, Shingo Kajimura, Kosaku Shinoda, Kenji Ikeda, Pema Maretich, Yangyu Yang, Yutaka Hasegawa, Daniel Stifler, Suneil K. Koliwad, Paul Cohen, Yasushi Ishigaki, Takashi Hosono, Yong Chen
Publikováno v:
Cell metabolism, vol 27, iss 1
Summary Adipose tissue fibrosis is a hallmark of malfunction that is linked to insulin resistance and type 2 diabetes; however, what regulates this process remains unclear. Here we show that the PRDM16 transcriptional complex, a dominant activator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f631fabf50efb970fd99a3574704fc68
https://europepmc.org/articles/PMC5765755/
https://europepmc.org/articles/PMC5765755/
Publikováno v:
Trends in endocrinology and metabolism: TEM. 29(3)
Two types of thermogenic fat cells, brown adipocytes and beige adipocytes, play a key role in the regulation of systemic energy homeostasis in mammals. Both brown fat and beige fat possess thermogenic properties in addition to common morphological an