Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ulrich Spengler"'
Autor:
Leona Dold, K. Ommer, Benjamin Krämer, Christoph Boesecke, J. K. Rockstroh, L. Zimmer, Jacob Nattermann, C. Schwarze-Zander, Bettina Langhans, Christian P. Strassburg, J. C. Wasmuth, B. Gathof, Ulrich Spengler, Raphael Mohr
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Abstract HLA-B*57 affects the course of HIV infection. Under antiretroviral therapy, its effects cannot be explained by outstandingly efficient T cell responses alone but may also involve cells of innate immunity. Studying in vitro stimulation with P
Autor:
Juergen K. Rockstroh, Christoph Boesecke, Leona Dold, Bettina Langhans, Christian P. Strassburg, Ulrich Spengler, Jan-Christian Wasmuth, Carolynne Schwarze-Zander, Raphael Mohr
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
HIV/HCV infection is supposed to substantially reduce survival as compared to HIV mono-infection. Here, we compared longtime-survival and causes of death in a cohort of HIV- and HIV/HCV-co-infected patients on combined antiretroviral therapy (cART),
Autor:
Leona Dold, Mette Juul Nielsen, Christoph Boesecke, Jenny Bischoff, Michael Praktiknjo, Christian Jansen, Ulrich Spengler, Carolynne Schwarze-Zander, Jonel Trebicka, Jürgen K. Rockstroh, Morten A. Karsdal, Robert Schierwagen, Raphael Mohr, Diana Julie Leeming, Jan-Christian Wasmuth
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219526 (2019)
Dold, L, Nielsen, M J, Praktiknjo, M, Schwarze-Zander, C, Boesecke, C, Schierwagen, R, Mohr, R, Wasmuth, J-C, Jansen, C, Bischoff, J, Rockstroh, J K, Karsdal, M A, Spengler, U, Trebicka, J & Leeming, D J 2019, ' Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART ', PLOS ONE, vol. 14, no. 7, e0219526 . https://doi.org/10.1371/journal.pone.0219526
PLoS ONE
Dold, L, Nielsen, M J, Praktiknjo, M, Schwarze-Zander, C, Boesecke, C, Schierwagen, R, Mohr, R, Wasmuth, J-C, Jansen, C, Bischoff, J, Rockstroh, J K, Karsdal, M A, Spengler, U, Trebicka, J & Leeming, D J 2019, ' Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART ', PLOS ONE, vol. 14, no. 7, e0219526 . https://doi.org/10.1371/journal.pone.0219526
PLoS ONE
BACKGROUND AND AIMS: Although combined antiretroviral treatment (cART) has improved overall survival of HIV infected patients, liver fibrosis and liver related-mortality still constitute major challenges in HIV positive patients. Collagen accumulates
Autor:
Ulrich Spengler, Jonel Trebicka, S Schlabe, Bonaventura Clotet, Josep M. Llibre, Juergen K. Rockstroh, Christoph Boesecke, JC Wasmuth, Jakob J Malin, Carolynne Schwarze-Zander, M Vasylyev, T Jou
Publikováno v:
HIV medicine. 20(3)
OBJECTIVES The aim of the study was to assess the regression of liver stiffness after successful direct-acting antiviral (DAA) treatment in patients with hepatitis C virus (HCV) monoinfection and HCV/-HIV coinfection. In addition, we aimed to identif
Autor:
Christoph Boesecke, Jacob Nattermann, Christian P. Srassburg, Andreas Glässner, Ulrich Spengler, Benjamin Krämer, Jürgen K. Rockstroh, P Kokordelis, Esther Voigt, Patrick Ingiliz, F Wolter
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 70:338-346
OBJECTIVE To analyze the role of CD3(+)CD56(+) natural killer (NK)-like T cells in HIV(+) patients with acute hepatitis C. DESIGN Frequency, phenotype, and anti-hepatitis C virus (HCV) activity of CD3(+)CD56(+) NK-like T cells were studied in 36 HIV(
Autor:
Christoph Boesecke, Morten A. Karsdal, Jonel Trebicka, Christian P. Strassburg, Ulrich Spengler, Diana Julie Leeming, Aleksander Krag, Søren Møller, Evrim Anadol, Mette Juul Nielsen, Inger Byrjalsen, Flemming Bendtsen, Robert Schierwagen, Jürgen K. Rockstroh, Carolyn Schwarzer-Zander
Publikováno v:
Leeming, D J, Anadol, E, Schierwagen, R, Karsdal, M A, Byrjalsen, I, Nielsen, M J, Schwarzer-Zander, C, Boesecke, C, Bendtsen, F, Møller, S, Strassburg, C P, Spengler, U, Krag, A, Rockstroh, J & Trebicka, J K 2014, ' Combined antiretroviral therapy attenuates hepatic extracellular matrix remodeling in HIV patients assessed by novel protein fingerprint markers ', AIDS, vol. 28, no. 14, pp. 2081-2090 . https://doi.org/10.1097/QAD.0000000000000388
OBJECTIVES: Combined antiretroviral therapy (cART) attenuates hepatic fibrosis in hepatitis C virus and HIV coinfected patients. However, the role of HIV or cART on hepatic fibrosis in HIV monoinfection is discussed controversially. During liver fibr
Autor:
Jürgen K. Rockstroh, Dominik J. Kaczmarek, Christoph Boesecke, Felix Goeser, Tobias van Bremen, Robert Hüneburg, Ulrich Spengler, Carolynne Schwarze-Zander, Steffen Manekeller, Vittorio Branchi, Christian P. Strassburg, Andreas Glässner, Benjamin Krämer, Tobias J. Weismüller, Hans Dieter Nischalke, Jacob Nattermann, Philipp Lutz
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006373 (2017)
PLoS Pathogens
PLoS Pathogens
Innate lymphocyte cells (ILCs), a novel family of innate immune cells are considered to function as key orchestrators of immune defences at mucosal surfaces and to be crucial for maintaining an intact intestinal barrier. Accordingly, first data sugge
Autor:
Dominik J. Kaczmarek, Jacob Nattermann, Benjamin Krämer, Carolynne Schwarze-Zander, P Kokordelis, Ulrich Spengler, Andreas Glässner, F Wolter, Christoph Boesecke, Jürgen K. Rockstroh, Philipp Lutz, Felix Goeser, Christian P. Strassburg
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174465 (2017)
PLoS ONE
PLoS ONE
Background A relevant proportion of human immunodeficiency virus (HIV) infected patients is co-infected with the hepatitis C virus (HCV). HCV co-infection in HIV-positive patients is associated with faster progression of liver disease in comparison t
Autor:
M Eisenhardt, Benjamin Krämer, Christoph Boesecke, Ulrich Spengler, Andreas Glässner, Jacob Nattermann, P Kokordelis, Jürgen K. Rockstroh, Hans-Dieter Nischalke, F Wolter
Publikováno v:
AIDS. 28:1879-1884
Objective The objective of this study was to analyse the potential role of CD27 in natural killer (NK) cell-mediated control of hepatitis C virus (HCV) infection in HIV-positive patients. Design Frequency of CD27-expressing CD56 NK cells was analysed
Publikováno v:
Current Opinion in HIV and AIDS. 9:365-370
Liver disease is one of the main causes of non-AIDS death in HIV-infected individuals from Europe and North America and has been attributed mainly to coinfection with hepatotropic viruses. However, HIV-induced inflammation as well as long-term antire