Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Richard A, Koup"'
Autor:
Koup RA; Richard A. Koup, Barney S. Graham and Daniel C. Douek are at the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3017, USA., Graham BS, Douek DC
Publikováno v:
Nature reviews. Immunology [Nat Rev Immunol] 2011 Jan; Vol. 11 (1), pp. 65-70. Date of Electronic Publication: 2010 Dec 17.
Autor:
Alessandra, Noto, Madeleine, Suffiotti, Victor, Joo, Antonio, Mancarella, Francesco A, Procopio, Guy, Cavet, Yvonne, Leung, Jean-Marc, Corpataux, Matthias, Cavassini, Agostino, Riva, Leonidas, Stamatatos, Raphael, Gottardo, Adrian B, McDermott, Richard A, Koup, Craig, Fenwick, Matthieu, Perreau, Giuseppe, Pantaleo
Publikováno v:
Frontiers in immunology. 13
Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells. We have found that the expression of CXCR3 defines distinct Tfh subsets: CXCR3
Autor:
Denis R. Beckford-Vera, Robert R. Flavell, Youngho Seo, Enrique Martinez-Ortiz, Maya Aslam, Cassandra Thanh, Emily Fehrman, Marion Pardons, Shreya Kumar, Amelia N. Deitchman, Vahid Ravanfar, Brailee Schulte, I-Wei Katherine Wu, Tony Pan, Jacqueline D. Reeves, Christopher C. Nixon, Nikita S. Iyer, Leonel Torres, Sadie E. Munter, Tony Hyunh, Christos J. Petropoulos, Rebecca Hoh, Benjamin L. Franc, Lucio Gama, Richard A. Koup, John R. Mascola, Nicolas Chomont, Steven G. Deeks, Henry F. VanBrocklin, Timothy J. Henrich
Publikováno v:
Nature communications, vol 13, iss 1
NATURE COMMUNICATIONS
NATURE COMMUNICATIONS
A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of persistently infected cells that establish a long-lived viral reservoir. HIV largely resides in anatomical regions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f7376a89268f2c2ee743d5b5d8c944
https://escholarship.org/uc/item/44v772pr
https://escholarship.org/uc/item/44v772pr
Autor:
Katherine V. Houser, Edmund V. Capparelli, John R. Mascola, Britta Flach, Adrian B. McDermott, Barney S. Graham, Emily E. Coates, Richard A. Koup, Mina Nikanjam, Lucio Gama, Jerry Li, Coleen K. Cunningham, Elizabeth J. McFarland, Bob C. Lin, Julie E. Ledgerwood
Publikováno v:
Clin Pharmacol Ther
VRC01 is a first-in-class, potent, broadly neutralizing antibody that targets the CD4 binding site of gp120 on HIV-1 viruses, and is under development as a novel HIV therapeutic. This study utilized population pharmacokinetic modeling to characterize
Autor:
Boris Julg, Kathryn E. Stephenson, Kshitij Wagh, Sabrina C. Tan, Rebecca Zash, Stephen Walsh, Jessica Ansel, Diane Kanjilal, Joseph Nkolola, Victoria E. K. Walker-Sperling, Jasper Ophel, Katherine Yanosick, Erica N. Borducchi, Lori Maxfield, Peter Abbink, Lauren Peter, Nicole L. Yates, Martina S. Wesley, Tom Hassell, Huub C. Gelderblom, Allen deCamp, Bryan T. Mayer, Alicia Sato, Monica W. Gerber, Elena E. Giorgi, Lucio Gama, Richard A. Koup, John R. Mascola, Ana Monczor, Sofia Lupo, Charlotte-Paige Rolle, Roberto Arduino, Edwin DeJesus, Georgia D. Tomaras, Michael S. Seaman, Bette Korber, Dan H. Barouch
Publikováno v:
Nature medicine. 28(6)
HIV-1 therapy with single or dual broadly neutralizing antibodies (bNAbs) has shown viral escape, indicating that at least a triple bNAb therapy may be needed for robust suppression of viremia. We performed a two-part study consisting of a single-cen
Autor:
Cynthia L Gay, Katherine S James, Marina Tuyishime, Shane D Falcinelli, Sarah B Joseph, Matthew J Moeser, Brigitte Allard, Jennifer L Kirchherr, Matthew Clohosey, Samuel L M Raines, David C Montefiori, Xiaoying Shen, Robert J Gorelick, Lucio Gama, Adrian B McDermott, Richard A Koup, John R Mascola, Michelle Floris-Moore, JoAnn D Kuruc, Guido Ferrari, Joseph J Eron, Nancie M Archin, David M Margolis
Publikováno v:
J Infect Dis
We tested the combination of a broadly neutralizing HIV antibody with the latency reversal agent vorinostat (VOR). Eight participants received 2 month-long cycles of VRC07-523LS with VOR. Low-level viremia, resting CD4+ T-cell–associated HIV RNA (r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faf11d8516c4ae68e516f570f2bdba2
https://europepmc.org/articles/PMC8889279/
https://europepmc.org/articles/PMC8889279/
Autor:
Amarendra Pegu, Giulia Fabozzi, Joana Dias, John R. Mascola, Wanwisa Promsote, Cassandra G. Almasri, Richard A. Koup, Lucio Gama, Constantinos Petrovas, John Paul Todd, Jonathan Fintzi, Yoshiaki Nishimura, Mangaiarkarasi Asokan, Kylie March, Malcolm A. Martin, Jeffrey D. Lifson
Publikováno v:
J Clin Invest
Primary HIV-1 infection can be classified into six Fiebig stages based on virological and serological laboratory testing, whereas simian-HIV (SHIV) infection in nonhuman primates (NHPs) is defined in time post-infection, making it difficult to extrap
Autor:
Denis R, Beckford-Vera, Robert R, Flavell, Youngho, Seo, Enrique, Martinez-Ortiz, Maya, Aslam, Cassandra, Thanh, Emily, Fehrman, Marion, Pardons, Shreya, Kumar, Amelia N, Deitchman, Vahid, Ravanfar, Brailee, Schulte, I-Wei Katherine, Wu, Tony, Pan, Jacqueline D, Reeves, Christopher C, Nixon, Nikita S, Iyer, Leonel, Torres, Sadie E, Munter, Tony, Hyunh, Christos J, Petropoulos, Rebecca, Hoh, Benjamin L, Franc, Lucio, Gama, Richard A, Koup, John R, Mascola, Nicolas, Chomont, Steven G, Deeks, Henry F, VanBrocklin, Timothy J, Henrich
Publikováno v:
Nature communications. 13(1)
A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of persistently infected cells that establish a long-lived viral reservoir. HIV largely resides in anatomical regions that
Autor:
Constantinos Petrovas, Richard A. Koup, Guillaume Stewart-Jones, Jorge R. Almeida, Sarah Rowland-Jones, Assan Jaye, David Wolinsky, Samuel Darko, Eirini Moysi, Daniel C. Douek, Ester Gea-Mallorquí, Yanchun Peng, Tao Dong
Publikováno v:
European journal of immunologyReferences. 51(10)
The dynamics of T-cell receptor (TCR) selection in chronic HIV-1 infection, and its association with clinical outcome, is well documented for an array of MHC-peptide complexes and disease stages. However, the factors that may contribute to the select
Publikováno v:
Methods. 154:118-124
Bispecific (bs) antibodies (Abs, bsAbs) are engineered immunoglobulins that contain two different antigen-binding sites in one molecule. bsAbs can be divided in two molecular formats; the IgG-like and non-IgG like. The structural elements of each for