Zobrazeno 21 - 30
of 146
pro vyhledávání: '"Richard A, Koup"'
Autor:
Edward K Sarfo, Nicole A. Doria-Rose, Diana G. Scorpio, Raffaello Verardi, Sijy O'Dell, Michael Worobey, Yaroslav Tsybovsky, Kathryn E. Foulds, Gwo-Yu Chuang, Frank J. Arnold, Cheng Cheng, Tongqing Zhou, Li Ou, Hui Geng, Winston Wu, Kevin Liu, John Paul Todd, Alexander J. Jafari, Michael Chambers, Richard A. Koup, Adrian B. McDermott, Peter D. Kwong, Xuejun Chen, Kurt R. Hill, Hongying Duan, Rui Kong, Shuishu Wang, Vrc Production Program, Yiran Wang, Anita Changela, Lawrence Shapiro, Angela R. Corrigan, Kai Xu, John R. Mascola
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107981-(2020)
Summary: The HIV fusion peptide (FP) is a promising vaccine target. FP-directed monoclonal antibodies from vaccinated macaques have been identified that neutralize up to ∼60% of HIV strains; these vaccinations, however, have involved ∼1 year with
Autor:
Rajendra Pahwa, Varghese K. George, David Huddleston, David R. Ambrozak, Suresh Pallikkuth, Lesley R. de Armas, Savita Pahwa, Louis Gonzalez, Richard A. Koup, Constantinos Petrovas, Eirini Moysi
Publikováno v:
The Journal of clinical investigation. 128(7)
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral the
Autor:
Eirini Moysi, Timothy W. Schacker, Krystelle Nganou Makamdop, Jodi Anderson, Gregory J. Beilman, Jeffrey G. Chipman, Peter Mugyenyi, Cavan S. Reilly, Ted M. Ross, Jared Schuster, Ray Lanciotti, Daniel C. Douek, Torfi Hoskuldsson, Rafick Pierre Sekaly, Maria T. Arévalo, Patrick Ssengendo, Lydie Trautmann, Meghan K Rothenberger, Jordan Schoephoerster, Bartosz Grzywacz, Rama Akondy, Lin Zhang, Richard A. Koup, Samuel P. Callisto, Constantinos Petrovas, Cissy Kityo, Michael M. Lederman, Benigno Rodriguez, Thomas E. Schmidt, Francis Ssali, Thomas Reimann, Rafi Ahmed, Proscovia Muloma
Publikováno v:
Journal of clinical investigation, 128(7), 2763-2773. The American Society for Clinical Investigation
There is marked variability in vaccine efficacy among global populations. In particular, individuals in low- to middle-income countries have been shown to be less responsive to vaccines than those from developed nations. Several factors, including en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79d289bb353b80dc6906f101e312e59
https://pure.amc.nl/en/publications/lymphoid-tissue-fibrosis-is-associated-with-impaired-vaccine-responses(71efe01b-7c23-43d5-acdc-0a10c53ef7ef).html
https://pure.amc.nl/en/publications/lymphoid-tissue-fibrosis-is-associated-with-impaired-vaccine-responses(71efe01b-7c23-43d5-acdc-0a10c53ef7ef).html
Autor:
Morgan A, Reuter, Perla M, Del Rio Estrada, Marcus, Buggert, Constantinos, Petrovas, Sara, Ferrando-Martinez, Son, Nguyen, Alberto, Sada Japp, Yuria, Ablanedo-Terrazas, Amaranta, Rivero-Arrieta, Leticia, Kuri-Cervantes, Heidi M, Gunzelman, Emma, Gostick, David A, Price, Richard A, Koup, Ali, Naji, David H, Canaday, Gustavo, Reyes-Terán, Michael R, Betts
Publikováno v:
Cell reports
SUMMARY Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear. Here, we show that memory, f
Autor:
Manuel Leal, Amarendra Pegu, Michael Y. Gerner, Ilias Vagios, Sarah Andrews, Ezequiel Ruiz-Mateos, Eli Boritz, Constantinos Petrovas, Jason Hataye, Luz A. González-Hernández, Ronald N. Germain, Daniel C. Douek, Michael R. Betts, Arik Cooper, Amaranta Rivero, John R. Mascola, Perla M. Del Rio Estrada, Giuseppe Pantaleo, Yuria Ablanedo-Terrazas, David R. Ambrozak, Gustavo Reyes-Terán, Sara Ferrando-Martinez, Fernando Docobo, Joseph P. Casazza, Richard A. Koup, Kristin L. Boswell, Susan Moir, Eirini Moysi, Robert Paris, Claire Deleage, Adrian B. McDermott, Jacob D. Estes
Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 T cells are infrequently found within germinal centers (GCs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f10a9ec853f1d6ea89e3922788342c
https://europepmc.org/articles/PMC5497679/
https://europepmc.org/articles/PMC5497679/
The bar is high to improve on current combination antiretroviral therapy (ART), now highly effective, safe, and simple. However, antibodies that bind the HIV envelope are able to uniquely target the virus as it seeks to enter new target cells, or as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4adc2ffd24f840b0d300ba8f6d1b73
Autor:
F. Vidal, Ezequiel Ruiz-Mateos, Yolanda M. Pacheco, Rebeca S. de Pablo-Bernal, Sara Ferrando-Martinez, José Ramón Blanco, Miguel Genebat, Marta De Luna-Romero, Marta Montero, Manuel Leal, Jesús Basulto Santos, Santiago Jiménez de Ory, Félix Gutiérrez, Francisco J. Parras, María Ángeles Muñoz-Fernández, Richard A. Koup
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Background Thymic function has been mainly analyzed with surrogate peripheral markers affected by peripheral T-cell expansion, making it difficult to assess the role of thymic failure in human immunodeficiency virus (HIV) disease progression. The ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba31bd2196380d2cdfd6b43b73beab8
https://hdl.handle.net/20.500.12530/32746
https://hdl.handle.net/20.500.12530/32746
Autor:
Mario Roederer, Salim S. Abdool Karim, Koleka Mlisana, Clive M. Gray, Richard A. Koup, Catherine Riou, Carolyn Williamson, Wendy A. Burgers
Publikováno v:
Journal of Virology. 88:1819-1824
Defining the characteristics of HIV-specific CD8 + T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8 + response at ap
Autor:
KaSaundra Oden, John R. Mascola, Michael Messer, Bernadette Jarocki, Barney S. Graham, James A. Hoxie, Anthony S. Fauci, Sijy O'Dell, Rebecca M. Lynch, Katharine J. Bar, Jana Blazkova, Nicole A. Doria-Rose, Mary E. Petrone, Benjamin Scheinfeld, Randall Tressler, Richard Kwan, Edward F. Kreider, Edmund V. Capparelli, Linda Harrison, Edgar T. Overton, Gerald H. Learn, Richard A. Koup, Michael C. Sneller, D. Brenda Salantes, Michael A. Proschan, Pablo Tebas, Katherine E Clarridge, Catherine Seamon, Nancy B Tustin, Robert T. Bailer, J. Shawn Justement, Julie E. Ledgerwood, Eric W. Refsland, Susan Moir, Tae-Wook Chun, Andrea Shiakolas, Mark Bardsley, Patrick J Madden
Publikováno v:
The New England journal of medicine. 375(21)
The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passiv
Autor:
Marlous L. Grijsen, John R. Mascola, Rebecca M. Lynch, Adam K. Wheatley, Jan M. Prins, Richard A. Koup, Madhu Prabhakaran, Godelieve J. de Bree, Adrian B. McDermott, Stephen D. Schmidt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
Background Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie