Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Richard A, Koup"'
Autor:
Denis R. Beckford-Vera, Robert R. Flavell, Youngho Seo, Enrique Martinez-Ortiz, Maya Aslam, Cassandra Thanh, Emily Fehrman, Marion Pardons, Shreya Kumar, Amelia N. Deitchman, Vahid Ravanfar, Brailee Schulte, I-Wei Katherine Wu, Tony Pan, Jacqueline D. Reeves, Christopher C. Nixon, Nikita S. Iyer, Leonel Torres, Sadie E. Munter, Tony Hyunh, Christos J. Petropoulos, Rebecca Hoh, Benjamin L. Franc, Lucio Gama, Richard A. Koup, John R. Mascola, Nicolas Chomont, Steven G. Deeks, Henry F. VanBrocklin, Timothy J. Henrich
Publikováno v:
Nature communications, vol 13, iss 1
NATURE COMMUNICATIONS
NATURE COMMUNICATIONS
A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure of HIV infection is the presence of persistently infected cells that establish a long-lived viral reservoir. HIV largely resides in anatomical regions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f7376a89268f2c2ee743d5b5d8c944
https://escholarship.org/uc/item/44v772pr
https://escholarship.org/uc/item/44v772pr
Autor:
Sung Hee Ko, Wei Shi, Anna Maximova, Wanwisa Promsote, Laura E. Liao, Richard A. Koup, Eli Boritz, John R. Mascola, Katharine Best, Jeffrey D. Lifson, Keenan Ernste, Mangaiarkarasi Asokan, Daniel C. Douek, Alan S. Perelson, Andrew R. Crowley, Joana Dias, Krisha McKee, Amarendra Pegu, Jianfei Hu, Xuejun Chen, Rafick Pierre Sekaly, Cuiping Liu, Slim Fourati, John-Paul Todd, David R. Ambrozak, Cassandra G Almasri, Lucio Gama, Margaret E. Ackerman, Divya Kilam
Publikováno v:
Proc Natl Acad Sci U S A
Treatment of HIV infection with either antiretroviral (ARV) therapy or neutralizing monoclonal antibodies (NAbs) leads to a reduction in HIV plasma virus. Both ARVs and NAbs prevent new rounds of viral infection, but NAbs may have the additional capa
Autor:
Marlous L. Grijsen, John R. Mascola, Rebecca M. Lynch, Adam K. Wheatley, Jan M. Prins, Richard A. Koup, Madhu Prabhakaran, Godelieve J. de Bree, Adrian B. McDermott, Stephen D. Schmidt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
Background Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie
Autor:
S. Munir Alam, Guido Ferrari, Thomas N. Denny, Stephen D. Schmidt, Mark K. Louder, Brandy M. Ward, Norman L. Letvin, Hugh C. Welles, Rosemarie D. Mason, Ling Shen, Celia C. LaBranche, Raphael Gottardo, Kathryn E. Foulds, Kelly E. Seaton, Martha Nason, Robert T. Bailer, Robert A. Seder, Will Fischer, Linh Mach, Mario Roederer, John R. Mascola, Georgia D. Tomaras, Bette T. Korber, Srinivas S. Rao, John Paul Todd, Brandon F. Keele, Adam P. Buzby, Gary J. Nabel, Richard A. Koup, Zhi-Yong Yang, David C. Montefiori, Wenjuan Gu
Publikováno v:
Nature
A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian immunodeficiency virus (SIV). We sho
Autor:
Olivia K. Donau, Alicia Buckler-White, Rajeev Gautam, Jovana Golijanin, Anna Gazumyan, Richard A. Koup, Michel C. Nussenzweig, Anthony S. Fauci, Masashi Shingai, Kathryn E. Foulds, Reza Sadjadpour, Jeffrey D. Lifson, Malcolm A. Martin, Ronald J. Plishka, Michael S. Seaman, Tae-Wook Chun, Mitzi M. Donaldson, Yoshiaki Nishimura, Florian Klein
Publikováno v:
Nature. 543(7646)
Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which leads to the establishment of T-cell immunity and resultant long-term infection control. No eff
Autor:
Timothy J. Wilkin, Philip L. Felgner, Johannes S. Gach, Chase T. M. Anderson, Steven G. Deeks, Christine Katlama, Donald N. Forthal, Andrea Gorlani, Chad J. Achenbach, Brigitte Autran, Richard A. Koup, Emmanuel Y. Dotsey, Joseph P. Casazza, Baiba Berzins, Juan C. Becerra, Robert L. Murphy
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160341 (2016)
PLoS ONE
PloS one, vol 11, iss 8
PLoS ONE
PloS one, vol 11, iss 8
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular immune respo
Autor:
Brigitte Autran, Rémi Cheynier, Yin Xu, Adrien Six, Arnaud Moris, Angeline Rouers, Lucie Colineau, Assia Samri, Alejandra Urrutia, Takuya Yamamoto, Anthony D. Kelleher, Stéphanie Graff-Dubois, Richard A. Koup, Sylvain Cardinaud, Karim Dorgham, Pierre-Grégoire Coulon, Anne Hosmalin, Eric Oksenhendler, John Zaunders, Hang-Phuong Pham
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
International audience; Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b99955d4a70eff404e532fbe2a1260
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
Autor:
Srinivas S. Rao, Jason Hataye, Keyun Wang, Joseph P. Casazza, Tongqing Zhou, Lan Wu, Zhi Yong Yang, Amarendra Pegu, Wei Shi, Richard A. Koup, John Paul Todd, Peter D. Kwong, Gary J. Nabel, Ivelin S. Georgiev, Xiaoti Guo, Xuejun Chen, Mangaiarkarasi Asokan, Sijy O'Dell, John R. Mascola
Publikováno v:
Nature Communications
The treatment of AIDS with combination antiretroviral therapy (cART) remains lifelong largely because the virus persists in latent reservoirs. Elimination of latently infected cells could therefore reduce treatment duration and facilitate immune reco
Autor:
Eirini Moysi, Takuya Yamamoto, Robert Paris, Constantinos Petrovas, Sara Ferrando-Martinez, Kristin L. Boswell, Richard Haubrich, Eva Archer, David R. Ambrozak, Mark Connors, Joseph P. Casazza, Richard A. Koup, Julie A Ake, Jerome H. Kim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
The role of PD-1 expression on CD4 T cells during HIV infection is not well understood. Here, we describe the differential expression of PD-1 in CD127high CD4 T cells within the early/intermediate differentiated (EI) (CD27highCD45RAlow) T cell popula
Autor:
Padma Malyala, Stephen D. Schmidt, Sam Darko, Rebecca M. Lynch, Lawrence Shapiro, Nicholas Valiante, Nisc Comparative Sequencing Program, Yoshiaki Nishimura, John R. Mascola, Robert A. Seder, Takuya Yamamoto, Malcolm A. Martin, Daniel C. Douek, Ennio De Gregorio, David Wolinsky, Manmohan Singh, Thomas B. Kepler, Barbara J. Flynn, Martha Nason, Zizhang Sheng, Rodrigo Matus-Nicodemos, Brandon F. Keele, Susan W. Barnett, Masashi Shingai, Akshaya Ramesh, Richard A. Koup, Joseph R. Francica, Zhenhai Zhang, Derek T. O'Hagan
Publikováno v:
Nature Communications
Developing predictive animal models to assess how candidate vaccines and infection influence the ontogenies of Envelope (Env)-specific antibodies is critical for the development of an HIV vaccine. Here we use two nonhuman primate models to compare th