Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Richard A, Koup"'
Autor:
Cynthia L Gay, Katherine S James, Marina Tuyishime, Shane D Falcinelli, Sarah B Joseph, Matthew J Moeser, Brigitte Allard, Jennifer L Kirchherr, Matthew Clohosey, Samuel L M Raines, David C Montefiori, Xiaoying Shen, Robert J Gorelick, Lucio Gama, Adrian B McDermott, Richard A Koup, John R Mascola, Michelle Floris-Moore, JoAnn D Kuruc, Guido Ferrari, Joseph J Eron, Nancie M Archin, David M Margolis
Publikováno v:
J Infect Dis
We tested the combination of a broadly neutralizing HIV antibody with the latency reversal agent vorinostat (VOR). Eight participants received 2 month-long cycles of VRC07-523LS with VOR. Low-level viremia, resting CD4+ T-cell–associated HIV RNA (r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faf11d8516c4ae68e516f570f2bdba2
https://europepmc.org/articles/PMC8889279/
https://europepmc.org/articles/PMC8889279/
Autor:
Constantinos Petrovas, Richard A. Koup, Guillaume Stewart-Jones, Jorge R. Almeida, Sarah Rowland-Jones, Assan Jaye, David Wolinsky, Samuel Darko, Eirini Moysi, Daniel C. Douek, Ester Gea-Mallorquí, Yanchun Peng, Tao Dong
Publikováno v:
European journal of immunologyReferences. 51(10)
The dynamics of T-cell receptor (TCR) selection in chronic HIV-1 infection, and its association with clinical outcome, is well documented for an array of MHC-peptide complexes and disease stages. However, the factors that may contribute to the select
Autor:
Richard A. Koup, Michel C. Nussenzweig, Yoshiaki Nishimura, Reza Sadjadpour, Sara Ferrando-Martinez, Malcolm A. Martin, Romas Geleziunas, Alicia Buckler-White, Rajeev Gautam, Olivia K. Donau, Eric Jesteadt, Joana Dias
Publikováno v:
The Journal of Experimental Medicine
Macaque recipients of anti–HIV-1 combination NAb treatment starting on PI day 3 or week 2 generate CD8+ cellular immunity that maintains durable suppression of SHIV replication and circulating CD4+ T cell levels during a 3–6-yr observation period
Autor:
Shannon Grant, Allan C. deCamp, Chenchen Yu, Susan Buchbinder, Edith Swann, Guido Ferrari, Barney S. Graham, Lindsay N. Carpp, Richard A. Koup, Shelly Karuna, Nicole Frahm, Holly Janes, Ian Frank, Mark J. Mulligan, Youyi Fong, Kelly E. Seaton, Robert T. Bailer, Xiaoying Shen, Barton F. Haynes, Georgia D. Tomaras, Magda Sobieszczyk, Richard M. Novak, M. Juliana McElrath, Vicki C Ashley, Michael C. Keefer, Spyros A. Kalams, Edwin DeJesus, David C. Montefiori, Aaron Deal, Peter B. Gilbert, Marcella Sarzotti-Kelsoe, Scott M. Hammer
Publikováno v:
The Journal of Infectious Diseases
Background HVTN 505 was a human immunodeficiency virus type 1 (HIV-1) preventive vaccine efficacy trial of a DNA/recombinant adenovirus serotype 5 (rAd5) vaccine regimen. We assessed antibody responses measured 1 month after final vaccination (month
Autor:
Peter B. Gilbert, Mark J. Mulligan, Susan Buchbinder, Douglas I. Grove, Greg Finak, Beryl A. Koblin, Raphael Gottardo, Holly Janes, Magdalena E. Sobieszczyk, Mingchao Shen, Nicole Frahm, Stephen C. De Rosa, Barney S. Graham, Chuka Anude, M. Juliana McElrath, Brittany Sanchez, Shelly Karuna, Elizabeth Adams, Lawrence Corey, Craig A. Magaret, Carter Bentley, Kristen W. Cohen, John Hural, Richard A. Koup, Scott M. Hammer, Michael C. Keefer
Publikováno v:
The Journal of Infectious Diseases. 215:1376-1385
Background It is important to identify vaccine-induced immune responses that predict the preventative efficacy of a human immunodeficiency virus (HIV)-1 vaccine. We assessed T-cell response markers as correlates of risk in the HIV Vaccine Trials Netw
The bar is high to improve on current combination antiretroviral therapy (ART), now highly effective, safe, and simple. However, antibodies that bind the HIV envelope are able to uniquely target the virus as it seeks to enter new target cells, or as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4adc2ffd24f840b0d300ba8f6d1b73
Autor:
Rupert Kaul, Connie J. Kim, Susan Moir, Cecilia T. Costiniuk, Gabor Kandel, Joseph P. Casazza, Erika Benko, Tae-Wook Chun, Colin Kovacs, Mario A. Ostrowski, Richard A. Koup, Jana Blazkova, J. Shawn Justement, Claire W. Hallahan, Anthony S. Fauci, Danielle Murray
Publikováno v:
The Journal of Infectious Diseases. 208:1443-1447
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent HIV and/or the dynamic
Autor:
Julie E. Ledgerwood, Raphael Gottardo, David Price, Emily C. Smith, Robert T. Bailer, Deborah Persaud, Frank Maldarelli, Emma Gostick, Charla A. Andrews, Ingelise J. Gordon, Barney S. Graham, Martha Nason, Mario Roederer, Ann Wiegand, Selorm Adzaku, Mary F. Kearney, David R. Ambrozak, Richard A. Koup, Joseph P. Casazza, Kathryn Bowman, Mary E. Enama, Carrie Ziemniak
Publikováno v:
The Journal of Infectious Diseases. 207:1829-1840
Background. The licensing of herpes zoster vaccine has demonstrated that therapeutic vaccination can help control chronic viral infection. Unfortunately, human trials of immunodeficiency virus (HIV) vaccine have shown only marginal efficacy.Methods.
Autor:
Pascal Poignard, Paul W. H. I. Parren, Richard A. Koup, Marie Claire Gauduin, Dennis R. Burton, Paola Fisicaro, Quentin J. Sattentau
Understanding the antibody response in HIV-1 infection is important to vaccine design. We have studied the antibody response to HIV-1 envelope at the molecular level and determined the characteristics of neutralizing and non-neutralizing antibodies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5e0cdb79453b986977d08c0052412b
https://doi.org/10.1016/s0165-2478(97)00043-6
https://doi.org/10.1016/s0165-2478(97)00043-6
Autor:
Richard A. Koup, Adrian B. McDermott
Publikováno v:
AIDS. 26:1281-1292
The complex interplay between the host immune response and HIV has been the subject of intense research over the last 25 years. HIV and simian immunodeficiency virus (SIV) CD8 T cells have been of particular interest since they were demonstrated to b