Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brandon J. DeKosky"'
Autor:
Bob C. Lin, John R. Mascola, Erica Normandin, Mallika Sastry, Divya Kilam, Li Ou, Shuishu Wang, Amy Ransier, Chen-Hsiang Shen, Kai Xu, Mark Connors, Mark K. Louder, Zizhang Sheng, Eric Feng, Reda Rawi, Eli Boritz, Baoshan Zhang, Brandon J. DeKosky, Rui Kong, Sung Hee Ko, Sijy O'Dell, Ying Gu, Peter D. Kwong, Kevin Liu, Gwo-Yu Chuang, Tongqing Zhou, Jesse Huang, Gunilla B. Karlsson Hedestam, Daniel C. Douek, Yiran Wang, Yicheng Guo, Stephen D. Schmidt, Lawrence Shapiro, Martin Corcoran, Cara W. Chao, Nicole A. Doria-Rose
Publikováno v:
Cell Host Microbe
Rare mutations have been proposed to restrict the development of broadly neutralizing antibodies against HIV-1, but this has not been explicitly demonstrated. We hypothesized that such rare mutations might be identified by comparing broadly neutraliz
Autor:
M. Anthony Moody, Aaron G. Schmidt, John Misasi, Wing Pui Kong, Bo Wang, Farida Laboune, John R. Mascola, George Georgiou, Chang W. Choi, Alberto Cagigi, Eun Sung Yang, Nancy J. Sullivan, Morgan R. Timm, Kwanyee Leung, Daniel C. Douek, Rui Kong, Julie E. Ledgerwood, Ahmed S. Fahad, Barney S. Graham, David R. Ambrozak, Jonathan R. McDaniel, Elise G. Viox, Erica Normandin, Brandon J. DeKosky, Jiwon Lee, Thomas Niezold, George Delidakis, Amy R. Henry, Aurélie Ploquin, Mark Connors, Leigh Kendra Elizabeth, Andrew D. Ellington, William N. Voss
Publikováno v:
Nature biotechnology
We present a technology to screen millions of B cells for natively paired human antibody repertoires. Libraries of natively paired, variable region heavy and light (VH:VL) amplicons are expressed in a yeast display platform that is optimized for huma
Autor:
Cinque Soto, John R. Mascola, Ivelin S. Georgiev, Brandon J. DeKosky, Lawrence Shapiro, Chaim A. Schramm, Peter D. Kwong, Zizhang Sheng, Thomas Lemmin, Gwo-Yu Chuang, An-Suei Yang, Tatyana Gindin
Publikováno v:
Immunological Reviews
Summary Numerous antibodies have been identified from HIV‐1‐infected donors that neutralize diverse strains of HIV‐1. These antibodies may provide the basis for a B cell‐mediated HIV‐1 vaccine. However, it has been unclear how to elicit sim
Autor:
John R. Mascola, Jonathan Stuckey, Miklos Guttman, George Georgiou, Kelly K. Lee, Baoshan Zhang, Barton F. Haynes, Peter D. Kwong, Mattia Bonsignori, Aliaksandr Druz, Robert T. Bailer, Thaddeus M. Davenport, Ivelin S. Georgiev, Xueling Wu, Penny L. Moore, Jonathan R. McDaniel, Marissa C. Jarosinski, Brandon J. DeKosky, Gwo-Yu Chuang, Max M. Yang, Jason Gorman, Nicole A. Doria-Rose, Adrian B. McDermott, Michael Chambers, Michael J. Ernandes, Marie Pancera, Mark K. Louder, Sandeep Narpala, Thomas Lemmin, Yongping Yang, Cinque Soto, Tongqing Zhou, Ulrich Baxa, Lawrence Shapiro, M. Gordon Joyce, Sherman Leung, Lynn Morris, James C. Mullikin, Nisc Comparative Sequencing Program
Publikováno v:
Nature structural & molecular biology
Broadly neutralizing antibodies (bNAbs) against HIV-1 Env V1V2 arise in multiple donors. However, atomic-level interactions had previously been determined only with antibodies from a single donor, thus making commonalities in recognition uncertain. H
Autor:
Peter D. Kwong, William R. Schief, Peng Zhao, Xuejun Chen, Yaroslav Tsybovsky, Cheng Cheng, Maryam Mukhamedova, Lance Wells, Oleksandr Kalyuzhniy, J.C. Boyington, Brandon J. DeKosky, Frederick W. Alt, Tyler Stephens, Ming Tian, Erica Normandin, Hongying Duan, John R. Mascola, Yi Zhang, Martha Nason, Alexander J. Jafari, Sergey Menis
Publikováno v:
Immunity. 49(2)
Summary An important class of HIV-1 broadly neutralizing antibodies, termed the VRC01 class, targets the conserved CD4-binding site (CD4bs) of the envelope glycoprotein (Env). An engineered Env outer domain (OD) eOD-GT8 60-mer nanoparticle has been d
Autor:
Hwei-Ling Cheng, Frederick W. Alt, William R. Schief, Barton F. Haynes, Eric Georgeson, Suvi Jain, Yiwei Chen, John R. Mascola, Wei Shi, Mai Dao, Michael T. Kimble, Zhou Du, Pei-Yi Huang, M. Gordon Joyce, Andrew T. McGuire, Ming Tian, Zizhang Sheng, Nicole A. Doria-Rose, Rita E. Chen, Sherry Lin, Yi Zhang, Leonidas Stamatatos, Sergey Menis, Erica Normandin, Farida Laboune, Amy R. Henry, Daniel C. Douek, Yimin Chen, Stephen D. Schmidt, Lawrence Shapiro, Lingshu Wang, Wing-Pui Kong, Hongying Duan, Elizabeth Cantor, Ivelin S. Georgiev, Brandon J. DeKosky, Misook Choe, Peter D. Kwong, Cheng Cheng, Xuejun Chen
The design of immunogens that elicit broadly reactive neutralizing antibodies (bnAbs) has been a major obstacle to HIV-1 vaccine development. One approach to assess potential immunogens is to use mice expressing precursors of human bnAbs as vaccinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b2ad5e362ec318e636379745cc527d
https://europepmc.org/articles/PMC5103708/
https://europepmc.org/articles/PMC5103708/