Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David Dilworth"'
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Autor:
Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Jinrong Min, Ronan P Hanley, Rima Al-awar, Matthieu Schapira, Lindsey I. James, Renato Ferreira de Freitas, Magdalena M. Szewczyk, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li, Carlos Zepeda-Velázquez, Elisa Gibson, David McLeod, Yanli Liu, Peter Brown, David Dilworth
Publikováno v:
J Med Chem
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported to date. Here, we pr
Autor:
Ernesto Guccione, Philipp Kaldis, Dalia Barsyte-Lovejoy, Danton Ivanochko, Magdalena M. Szewczyk, David Dilworth, Matthieu Schapira, Peter Loppnau, S. Zakiah A. Talib, Fengling Li, Solomon Kattar, Levon Halabelian, Ronan C. O'Hagan, Jabez Bok, Levi L. Blazer, Evelyne Lima-Fernandes, Genna M. Luciani, Nathan Palmer, Mohammad S. Eram, Cheryl H. Arrowsmith, Benjamin Nicholson, John M. Sanders, Peter Brown, Abdellah Allali-Hassani, Masoud Vedadi, Shawna Organ, Jessica Sook Yuin Ho, D. Jonathan Bennett, Qin Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results in altered meiotic gene transcription, impairment of double-stranded b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33e807d4565f7990902109995ea70c8
https://vb.gamtc.lt/GTC:ELABAPDB54740056&prefLang=en_US
https://vb.gamtc.lt/GTC:ELABAPDB54740056&prefLang=en_US
Autor:
Dalia Barsyte-Lovejoy, David Dilworth
Publikováno v:
Cellular and molecular life sciences : CMLS. 76(15)
The methylation of proteins is integral to the execution of many important biological functions, including cell signalling and transcriptional regulation. Protein methyltransferases (PMTs) are a large class of enzymes that carry out the addition of m
Autor:
Cheryl H. Arrowsmith, David Dilworth
Publikováno v:
Structure (London, England : 1993). 26(12)
In this issue of Structure, Haddad et al. (2018) solve the high-resolution trimeric crystal structure of human COMPASS-like components Dpy-30 and Ash2L (2:1) to unravel an uncharacterized interaction surface required for competent H3K4 methylation in