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pro vyhledávání: '"James, Elliot"'
Autor:
Albert A. Bowers, Jack Taunton, Robert M. Williams, James Elliot Bradner, Stuart L. Schreiber, Nathan West
Publikováno v:
Journal of the American Chemical Society. 130:11219-11222
The efficient total synthesis of the recently described natural substance largazole (1) and it’s active metabolite largazole thiol (2) is described. The synthesis required eight linear steps and proceeded in 37% overall yield. It is demonstrated th
Autor:
Ramasamy Paulmurugan, Wendy M. Smith, Carmel T. Chan, Stuart L. Schreiber, Sanjiv S. Gambhir, Robert Reeves, Nathan West, Jun Qi, R. Paranol, Ralph Mazitschek, James Elliot Bradner, Gabriela Chiosis
Publikováno v:
Cancer research. 74(24)
Histone deacetylases (HDAC) that regulate gene expression are being explored as cancer therapeutic targets. In this study, we focused on HDAC6 based on its ability to inhibit cancerous Hsp90 chaperone activities by disrupting Hsp90/p23 interactions.
Autor:
Olaf Wiest, Stuart L. Schreiber, James Elliot Bradner, Robert M. Williams, Thomas J. Greshock, Guillermina Estiu, Nathan West, Albert A. Bowers
The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK228, largazole, and SAHA for inhibition of the class I HDACs 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88ce1ce8fc5c5d5c4b1f572f6abce85
https://europepmc.org/articles/PMC2880701/
https://europepmc.org/articles/PMC2880701/