Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Cheryl H. Arrowsmith"'
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Publikováno v:
Nature Structural & Molecular Biology. 26:863-869
Chromatin regulatory proteins are increasingly recognized as potential new drug targets. Many of these proteins harbor one or more so called ‘reader domains’ that recognize covalent modifications of lysine and arginine residues, typically on hist
Autor:
N. Berner, Magda Szewczyk, B. Kuester, J. Weckesser, Martin Eilers, Andreas Kraemer, Christoph A. Sotriffer, Volker Doetsch, Bikash Adhikari, Frank Loehr, Stephanie Heinzlmeir, Dalia Barsyte-Lovejoy, A. Doelle, Mathias Diebold, Elmar Wolf, J. Gerbel, Lena M. Berger, Stefan Knapp, Cheryl H. Arrowsmith
Histone H3K4 methylation serves as post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferases (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat containing protein 5 (WDR5) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb60d0d7a9cb8061918d0989716e03b
https://doi.org/10.1101/2021.04.12.439490
https://doi.org/10.1101/2021.04.12.439490
Autor:
Jinrong Min, Matthew R. Marunde, Dmitri Kireev, Jack Greenblatt, Ferreira de Freitas R, Tigran M. Abramyan, Cheryl H. Arrowsmith, Peter Brown, Magda Szewczyk, Irene Chau, A. Dong, Kazemzadeh S, Dalia Barsyte-Lovejoy, Ronan P Hanley, Mengqi Zhou, Y. Liu, Michael-Christopher Keogh, Lindsey I. James, Edyta Marcon, Matthieu Schapira, David Dilworth, Ming Lei, Popova Ik, Albina Bolotokova, Marcus A. Cheek, Masoud Vedadi, Elisa Gibson, Suzanne Ackloo, Su Qin, Matthew J. Meiners, Nathan W. Hall, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li
NSD2 is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two PWWP and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4c6ef23b32f1b09d83b9d0588c0ec9
https://doi.org/10.1101/2021.03.05.433782
https://doi.org/10.1101/2021.03.05.433782
Autor:
Minkui Luo, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Tiago Medina, H. Ümit Kaniskan, Matthieu Schapira, David Smil, Paul L. Richardson, Jian Jin, David McLeod, Colby Zaph, Andrew M. Lewis, Jennifer A. Ward, Daniel D. De Carvalho, Fengling Li, Sebastian Scheer, Jeffrey P. Northrop, Peter Brown, Kilian Huber, Yudao Shen, Suzanne Ackloo, Carlos Zepeda-Velázquez, Jing Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs
Autor:
Panagis Filippakopoulos, Dalia Barsyte-Lovejoy, Edyta Marcon, Elizabeth Henderson, Cheryl H. Arrowsmith, Jack Greenblatt, Ashley Hutchinson, Levon Halabelian, Alma Seitova, Danton Ivanochko, Pavel Savitsky, Evelyne Lima-Fernandes, Harshika Jain, Shili Duan
Publikováno v:
Nucleic Acids Research
Aberrant isoform expression of chromatin-associated proteins can induce epigenetic programs related to disease. The MDS1 and EVI1 complex locus (MECOM) encodes PRDM3, a protein with an N-terminal PR-SET domain, as well as a shorter isoform, EVI1, lac
Autor:
Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Jinrong Min, Ronan P Hanley, Rima Al-awar, Matthieu Schapira, Lindsey I. James, Renato Ferreira de Freitas, Magdalena M. Szewczyk, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li, Carlos Zepeda-Velázquez, Elisa Gibson, David McLeod, Yanli Liu, Peter Brown, David Dilworth
Publikováno v:
J Med Chem
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported to date. Here, we pr
Autor:
Jun Ding, Zhen Han, Cheryl H. Arrowsmith, Zhesi Zhu, Xiangkun Yang, Nawei Zhang, Minkui Luo, Jiabao Song, Hong Zeng, Levon Halabelian, Michael G. Bartlett, Maomao He, Yingming Zhao, Liza Ngo, Y. George Zheng
Publikováno v:
Nucleic Acids Research
Short-chain acylations of lysine residues in eukaryotic proteins are recognized as essential posttranslational chemical modifications (PTMs) that regulate cellular processes from transcription, cell cycle, metabolism, to signal transduction. Lysine b
Autor:
Bothayna Al-Gashgari, Alaguraj Veluchamy, Lorena V. Cortés-Medina, Wolfgang Fischle, Zhadyra Yerkesh, Abrar Aljahani, Dulat Azhibek, Sarah Kreuz, Alexander Lemak, Scott Houliston, Papita Mandal, Lixin Fan, Shili Duan, Cheryl H. Arrowsmith, Maria Tauber, Michelle S. Ong
Publikováno v:
Nucleic Acids Research
UHRF1 is an important epigenetic regulator associated with apoptosis and tumour development. It is a multidomain protein that integrates readout of different histone modification states and DNA methylation with enzymatic histone ubiquitylation activi
Autor:
Samuel Weiss, Leo J.Y. Kim, Xiaochong Wu, Randy Van Ommeren, Yanqing Jiang, Kaitlin Kharas, Evgeny Kanshin, Moloud Ahmadi, Alberto Delaidelli, Geneviève Deblois, David Przelicki, Stephane Angers, Hiromichi Suzuki, Sameer Agnihotri, Bradly G. Wouters, Graham MacLeod, Ricky Tsai, Pasqualino De Antonellis, Michelle Ly, Stacey L. Krumholtz, Paul Guilhamon, James Loukides, Ravi N. Vellanki, Alex Rasnitsyn, Hamza Farooq, Daniel Schramek, Nada Jabado, María Sánchez-Osuna, Laura K. Donovan, Vijay Ramaswamy, Ibrahim El-Hamamy, Joonas Haapasalo, Jeremy N. Rich, Michael D. Taylor, Benjamin A. Garcia, Mike Tyers, Kyle Juraschka, Winnie Ong, Olivier Saulnier, Panagiotis Prinos, John J.Y. Lee, Borja L. Holgado, Olga Sirbu, Craig Daniels, Cheryl H. Arrowsmith, Cory Richman, Poul H. Sorensen, Kulandaimanuvel Antony Michealraj, Sheila K. Singh, Andrea Bajic, Polina Balin, Stephen C. Mack, Betty Luu, Fiona J. Coutinho, Dilakshan Srikanthan, Florence M.G. Cavalli, Sachin Kumar, Evan Y. Wang, Mathieu Lupien, Peter B. Dirks, Maria C. Vladoiu, Lincoln Stein, Livia Garzia, Ahmad Malik, John Wojcik, Avesta Rastan
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4cbadadef8c1b79cfc6c9ec6f333d8
https://hdl.handle.net/11588/900834
https://hdl.handle.net/11588/900834