Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Wei-Yi Ong"'
Publikováno v:
Molecular Neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)—as seen by effects on smell, taste, seizures, stroke, ne
Publikováno v:
Molecular Neurobiology
The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas of the cerebral neocortex, hippocampus, periaqueductal gray (PAG), thalamus, amygdala, and b
Autor:
Jie-Xin Tong, Wei-Yi Ong, Gavin S. Dawe, Eng Shi Ong, Suku-Maran Shalini, Yee-Kong Ng, Christabel Fung-Yih Ho, Deron R. Herr
Publikováno v:
Molecular Neurobiology
Docosahexaenoic acid (DHA) is enriched in membrane phospholipids of the central nervous system (CNS) and has a role in aging and neuropsychiatric disorders. DHA is metabolized by the enzyme Alox15 to 17S-hydroxy-DHA, which is then converted to 7S-hyd
Publikováno v:
Neurochemistry International. 87:43-59
The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT
Autor:
Bamaprasad Dutta, Yu-Ying Ng, Siu Kwan Sze, Angela Jin-Rong Tan, Wee Siong Chew, Federico Torta, Deron R. Herr, Sneha Muralidharan, Laura Hui-Ru Tan, John Jia En Chua, Wei-Yi Ong
Publikováno v:
Molecular neurobiology. 55(7)
Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was gre
Publikováno v:
Neuroscience. 245:179-190
Brain iron accumulation and oxidative stress are common features of many neurodegenerative diseases, and could be due in part to increased iron influx across the blood-brain interface. The iron transport protein, divalent metal transporter 1 (DMT1) i
Autor:
Guanghou Shui, Chay Hoon Tan, Wei-Yi Ong, Akhlaq A. Farooqui, Lynette Hui-Wen Lee, Yew Long Lo, Markus R. Wenk
Publikováno v:
Metabolomics. 8:19-33
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used in the management of neurologic disorders such as depression and chronic pain, but little is known about how it could affect brain lipids, which play important roles in membrane
Autor:
Ji-Hyun Kim, Wei-Yi Ong
Publikováno v:
Journal of Chemical Neuroanatomy. 37:71-77
The transcription factor sterol regulatory element binding protein-2 (SREBP-2) has a key role in regulating cholesterol biosynthesis. In view of ongoing cholesterol biosynthesis in the brain, the present study was carried out to examine the distribut
Publikováno v:
The FASEB Journal. 20:1152-1161
Kainate is a glutamate analog that has been widely used in pharmacological studies of neuronal injury related to ischemic conditions and epilepsy. While altered lipid metabolism has been implicated in kainate action, no study has yet investigated the
Publikováno v:
Experimental Brain Research. 170:448-456
Potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function has been proposed as being useful in the treatment of depression, but thus far, little is known about the possible changes in AMPA receptor expression i