Zobrazeno 1 - 10
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pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
Aging (Albany NY)
We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged a
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
Neurochemical Research. 44:38-48
Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotr
Publikováno v:
Behavioural Brain Research. 322:223-232
Increased human longevity has magnified the negative impact that aging can have on cognitive integrity of older individuals experiencing some decline in cognitive function. Approximately 30% of the elderly will have cognitive problems that influence
Publikováno v:
The Journal of Neuroscience. 35:3966-3977
Young (3–6 months) and middle-age (10–14 months) rats were trained on the five-choice serial reaction time task. Attention and executive function deficits were apparent in middle-age animals observed as a decrease in choice accuracy, increase in
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
The Journal of Neuroscience. 33:15710-15715
NMDA receptors (NMDARs) play a critical role in learning and memory; however, there is a lack of evidence for a direct relationship between a well characterized decline in NMDAR function and impaired cognition during aging. The present study was desi
Autor:
Ling Jin, Brenna L Brim, N.M. Ellinwood, R. Haskell, Kathy R. Magnusson, Arvind Kumar, Thomas C. Foster, R. Awedikian
Publikováno v:
Behavioural Brain Research. 238:211-226
The GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor shows age-related declines in expression across the frontal cortex and hippocampus. This decline is strongly correlated to age-related memory declines. This study was designed to determin
Publikováno v:
Neuroscience. 113:89-97
Estradiol influences Ca(2+) regulation and Ca(2+)-dependent synaptic plasticity, suggesting estrogenic effects on Ca(2+)-dependent enzymes that regulate synaptic plasticity may mediate hormonal influences on cognition. In ovariectomized female rats,
Autor:
Thomas C. Foster, Theodore C. Dumas
Publikováno v:
Journal of Neurophysiology. 85:1377-1383
Exposure to novel environments or behavioral training is associated with increased strength at hippocampal synapses. The present study employed quantal analysis techniques to examine the mechanism supporting changes in synaptic transmission that occu
Publikováno v:
Brain Research. 736:243-250
An increase in medial perforant synaptic strength can be observed for hippocampal slices from rats exposed to environmental enrichment. The expression of enhanced synaptic strength exhibits properties similar to long-term potentiation (LTP), a physio
Autor:
Thomas C. Foster, Theodore C. Dumas
Publikováno v:
Developmental Brain Research. 105:137-139
Paired-pulse facilitation (PPF) of CA3–CA1 excitatory postsynaptic potentials (EPSP) was compared in hippocampal slices from juvenile (postnatal day (P) 15–21) and young adult rats (P28–P35) following application of adenosine. Relative to juven