Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Stephan C. Schürer"'
Autor:
Daniel J. Cooper, Stephan C. Schürer
Publikováno v:
Molecules
Volume 24
Issue 8
Molecules, Vol 24, Iss 8, p 1604 (2019)
Volume 24
Issue 8
Molecules, Vol 24, Iss 8, p 1604 (2019)
The Toxicology in the 21st Century (Tox21) project seeks to develop and test methods for high-throughput examination of the effect certain chemical compounds have on biological systems. Although primary and toxicity assay data were readily available
Autor:
Omar Moukha-Chafiq, Yali Dou, Chenzhong Liao, Vibha Pathak, Garrett S. Gibbons, Robert C. Reynolds, Amarraj Chakraborty, Stephan C. Schürer, Timothy S. Snowden, Afoma C. Umeano, Sierrah M. Grigsby, Zaneta Nikolovska-Coleska, Bini Mathew, Young Tae Lee
Publikováno v:
Eur J Med Chem
Disruptor of Telomeric Silencing 1-Like (DOT1L), the sole histone H3 lysine 79 (H3K79) methyltransferase, is required for leukemogenic transformation in a subset of leukemias bearing chromosomal translocations of the Mixed Lineage Leukemia (MLL) gene
Autor:
Stephan C. Schürer, Zhaohui Ni, Yongqun He, Caty Chung, Jiangan Xie, Daniel J. Cooper, Raymond Terryn, Vasileios Stathias, Qingping Liu, Yu Lin, Sirarat Sarntivijai, Edison Ong
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 18, Iss S17, Pp 43-53 (2017)
BMC Bioinformatics, Vol 18, Iss S17, Pp 43-53 (2017)
Background Aiming to understand cellular responses to different perturbations, the NIH Common Fund Library of Integrated Network-based Cellular Signatures (LINCS) program involves many institutes and laboratories working on over a thousand cell lines
Autor:
Uma D. Vempati, David Murray, Linda Zander Balderud, Niklas Larsson, Stephan C. Schürer, Marcus Bjäreland, Ola Engkvist
Publikováno v:
Journal of biomolecular screening. 20(3)
High-throughput screening (HTS) is the main starting point for hit identification in drug discovery programs. This has led to a rapid increase of available screening data both within pharmaceutical companies and the public domain. We have used the Bi
Autor:
Mark R. Southern, Zihan Liu, Jeremy J. Yang, Joshua A. Bittker, Rajarshi Guha, Yasel Cruz, J. Levine, John C. Braisted, G. Walzer, Jacob K. Asiedu, Philip Montgomery, Shaita Picard, David L. Lahr, D. Durkin, Thomas D.Y. Chung, J. N. Rose, Dac-Trung Nguyen, Cordelle Tanega, Benjamin Alexander, D. A. Stonich, Simon Chatwin, Eleanor A. Howe, Stuart L. Schreiber, Paul A. Clemons, X. Xiang, Noel Southall, Stephan C. Schürer, J. T. Rose, Steve Brudz, A. de Souza
Publikováno v:
Nucleic Acids Research
BARD, the BioAssay Research Database (https://bard.nih.gov/) is a public database and suite of tools developed to provide access to bioassay data produced by the NIH Molecular Libraries Program (MLP). Data from 631 MLP projects were migrated to a new
Publikováno v:
Bioinformatics (Oxford, England). 29(24)
Motivation: Novel tools need to be developed to help scientists analyze large amounts of available screening data with the goal to identify entry points for the development of novel chemical probes and drugs. As the largest class of drug targets, G p
Autor:
Caroline E. Shamu, Christopher C. Mader, Gabriel F. Berriz, Sean D. Erickson, David Wrobel, Cyril H. Benes, Nakul Datar, Dusica Vidovic, Caty Chung, Amar Koleti, Ajay S. Pillai, Uma D. Vempati, Stephan C. Schürer, Jeremy L. Muhlich, Aravind Subramanian
Publikováno v:
J Biomol Screen
The National Institutes of Health Library of Integrated Network-based Cellular Signatures (LINCS) program is generating extensive multidimensional data sets, including biochemical, genome-wide transcriptional, and phenotypic cellular response signatu
Autor:
Ahsan Mir, Uma D. Vempati, Saminda Abeyruwan, Kunie Sakurai, Stephan C. Schürer, Caty Chung, Magdalena J. Przydzial, Vance Lemmon, Ubbo Visser
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e49198 (2012)
PLoS ONE, Vol 7, Iss 11, p e49198 (2012)
Huge amounts of high-throughput screening (HTS) data for probe and drug development projects are being generated in the pharmaceutical industry and more recently in the public sector. The resulting experimental datasets are increasingly being dissemi
Autor:
Sarwat Chowdhury, Peter Chase, Thomas D. Bannister, Timothy P. Spicer, Peter Hodder, Daniel W. Zaharevitz, Melissa Crisp, Yuanjun He, Vincent W. Yang, Franck Madoux, Agnieszka Bialkowska, Chenlu Tian, Stephan C. Schürer
The transcription factor Krüppel-like factor 5 (KLF5) is primarily expressed in the proliferative zone of the mammalian intestinal epithelium, where it regulates cell proliferation. Studies showed that inhibition of KLF5 expression reduces prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d3a6e19206e2ede64d0fad7896c49b
https://europepmc.org/articles/PMC3213326/
https://europepmc.org/articles/PMC3213326/
Publikováno v:
Journal of biomolecular screening. 16(4)
High-throughput screening data repositories, such as PubChem, represent valuable resources for the development of small-molecule chemical probes and can serve as entry points for drug discovery programs. Although the loose data format offered by PubC