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Autor:
Daniel W. Shi, Yu Fu, Yanbo Tang, Xuan Zheng Shi, Shrilakshmi Hegde, Li Yen Mae Huang, You-Min Lin
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Constipation and abdominal pain are commonly encountered in opioid-induced bowel dysfunction (OBD). The underlying mechanisms are incompletely understood, and treatments are not satisfactory. As patients with OBD often have fecal retention, we aimed
Autor:
Osamu Ito, Takuo Hirose, Jiahe Qiu, Masahiro Kohzuki, Takahiro Miura, Yoichi Sato, Yasunori Sato
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G464-G473
Polycystic liver disease (PLD) is a hereditary liver disease in which the number of cysts increases over time, causing various abdominal symptoms and poor quality of life. Although effective treatment for PLD has not been established, we recently rep
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 318:G624-G634
Sacral nerve stimulation (SNS) was reported to improve 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. The aim of this study was to investigate whether the SNS anti-inflammatory effect is mediated via the local sacral splanchnic ne
Autor:
Marisol A. Ramirez Solano, Carine Beysen, Ryan M. Allen, Leslie R Sedgeman, Scott M. Turner, Kasey C. Vickers
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 315:G810-G823
Colesevelam is a bile acid sequestrant approved to treat both hyperlipidemia and type 2 diabetes, but the mechanism for its glucose-lowering effects is not fully understood. The aim of this study was to investigate the role of hepatic microRNAs (miRN
Autor:
Hiroyuki Nakamori, Yuuki Horii, Kurumi Kato, Kazuhiro Horii, Takahiko Shiina, Hiroki Shimaoka, Yasutake Shimizu, Kiyotada Naitou
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 315:G631-G637
The central regulating mechanisms of defecation, especially roles of the spinal defecation center, are still unclear. We have shown that monoamines including norepinephrine, dopamine, and serotonin injected into the spinal defecation center cause pro
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 313:G434-G441
Dopamine (DA)-containing fibers and neurons are embedded within the brain stem dorsal vagal complex (DVC); we have shown previously that DA modulates the membrane properties of neurons of the dorsal motor nucleus of the vagus (DMV) via DA1 and DA2 re
Autor:
Brendan J. Canning, Taku Suzuki, Jin Magara, Izumi Ujihara, Takanori Tsujimura, Shogo Sakai, Makoto Inoue, Kojun Tsuji
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 312:G498-G507
Dysphagia is caused not only by neurological and/or structural damage but also by medication. We hypothesized memantine, dextromethorphan, diazepam, and baclofen, all commonly used drugs with central sites of action, may regulate swallowing function.
Autor:
Yuuki Horii, Kazuhiro Horii, Akihiro Yamada, Hiroki Shimaoka, Yasutake Shimizu, Hidemasa Furue, Hiroyuki Nakamori, Takahiko Shiina, Hiroki Sakai, Kiyotada Naitou
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 317(4)
We previously demonstrated that administration of norepinephrine, dopamine, and serotonin into the lumbosacral defecation center caused propulsive contractions of the colorectum. It is known that the monoamines in the spinal cord are released mainly
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 310:G808-G821
Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involve
Autor:
Shiv Kumar Sarin, Erica Lafoz, Héctor García-Calderó, Juan Carlos García-Pagán, Jaume Bosch, Jordi Gracia-Sancho, Dinesh M. Tripathi, Eva Erice
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 309:G301-G309
Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanism